Clinical trials
Substance Use (Drugs, Alcohol) clinical trials
Below are recruiting substance use (drugs, alcohol) clinical trials, each written for real people, not researchers. We’re tracking 98 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05897164Recruiting
Mobile app to help teens cut back on substance use
This study tests a mobile app designed to help teens who use alcohol or drugs cut back or stop. You and your teen would use the app together and get support from the study team by text.
Baltimore, MarylandAges 13 years+ - NCT05743699Recruiting
Bright Horizons program for Native teens with recent binge drinking
This study tests the Bright Horizons program to help Native American youth who recently had a binge alcohol event. It looks at whether support and skills can reduce risky drinking and improve safety and wellbeing.
Whiteriver, ArizonaAges 10–24 - NCT07602270Recruiting
How a Ketogenic Diet Affects Alcohol in Your Body
This study tests whether eating a ketogenic diet (very low carb, high fat) changes how your body processes alcohol. Researchers will have you follow a special diet and then measure your body's response to controlled amounts of alcohol in a lab setting.
Philadelphia, PennsylvaniaAges 21–50 - NCT05538910Recruiting
Brain imaging study on substance use and depression
This study uses brain scans to understand how substance use and mental illness, like depression, are linked. It may help develop better treatments by looking at brain activity in people with and without depression.
Baltimore, MarylandAges 18–60 - NCT06484075RecruitingPhase 1/Phase 2
Sleep medication for alcohol use disorder
This study tests whether suvorexant, a sleep aid, can help people with alcohol use disorder by looking at brain changes. It may improve sleep and reduce drinking.
Bethesda, MarylandAges 18–75 - NCT06923423Recruiting
Cognitive processing therapy for drug use and trauma in prison
This study tests if a type of therapy called cognitive processing therapy (CPT) can help people in prison who have both a drug use problem and trauma-related stress. If you qualify, you would receive CPT and be compared to those getting usual care.
Little Rock, ArkansasAges 18 years+ - NCT07485036Recruiting
Study on mood and alcohol use in new mothers
This study looks at how new mothers feel emotionally, including mood, alcohol use, and symptoms of depression. By participating, you can help researchers understand the challenges mothers face in the first year after childbirth.
Chicago, IllinoisAges 18 years+ - NCT06794983Recruiting
Support after jail for health and substance use
This study tests a program that helps people leaving jail connect with healthcare and community services. It is for adults with a history of substance use and a chronic health condition who qualify for Wisconsin Medicaid.
Madison, WisconsinAges 18 years+ - NCT07214467Recruiting
Adaptive brain stimulation for opioid use disorder
This study tests a new type of brain stimulation that adapts to your brain activity, aiming to reduce cravings and help you control opioid use. It is for people with long-standing opioid use disorder who have not gotten lasting relief from at least 3 treatment attempts, including medication.
San Francisco, CaliforniaAges 22–75 - NCT06620276Recruiting
Ketamine and therapy for alcohol use disorder and depression
This trial tests if combining ketamine infusions with weekly therapy can help people who have both alcohol use disorder and hard-to-treat depression. You may qualify if you drink at least moderately, have treatment-resistant depression, and are willing to attend 8 therapy sessions.
Montreal, QuebecAges 18–70 - NCT07148843RecruitingPhase 2/Phase 3
CBD for alcohol withdrawal and cravings
This study tests whether adding CBD (a cannabis compound that doesn't get you high) to usual care can help reduce alcohol withdrawal symptoms and cravings. It may offer a new way to support people trying to cut down or stop drinking.
Baltimore, MarylandAges 21–65 - NCT06118580RecruitingPhase 2
Alcohol and aggression brain study
This study looks at how alcohol affects the brain in people with a history of aggression or alcohol use disorder. You may be able to join if you're a right-handed adult who drinks regularly and fits one of the specific groups being studied.
Columbus, OhioAges 21–55 - NCT07118618RecruitingPhase 2
Probenecid for alcohol cravings and drinking
This study tests if the medication probenecid can help reduce cravings for alcohol and the amount you drink. It is for people who drink heavily and have moderate to severe alcohol use disorder.
Providence, Rhode IslandAges 18 years+ - NCT03667846RecruitingPhase 2
Biomarker-guided treatment for drinking and PTSD symptoms
This Phase 2 study tests whether blood/brain “biomarkers” can help choose a treatment plan for people who have alcohol use disorder and PTSD. The goal is to improve outcomes related to drinking and PTSD symptoms compared with a standard approach.
New York, New YorkAges 18–70 - NCT07028983Recruiting
Music therapy for drug and alcohol addiction recovery
This trial tests if adding music therapy to standard addiction treatment helps people recover from substance use disorders. It is for adults who have completed detox and are not currently going through detox.
ViennaAges 18 years+ - NCT06693960RecruitingEarly Phase 1
Oregano and drug interaction study
This study looks at how oregano affects the way your body processes certain medications. It might help patients understand if oregano can change how drugs work.
Spokane, WashingtonAges 18–64 - NCT06494891RecruitingPhase 2
Understanding motivation for IV alcohol drinking
This study looks at why people with alcohol use disorder choose to drink alcohol given through an IV. The goal is to better understand the motivation behind drinking, which could help improve treatments.
Los Angeles, CaliforniaAges 21–65 - NCT05674409Recruiting
Telehealth family program for moderate to severe alcohol use
This study tests a brief treatment delivered by video that involves a Veteran and a concerned family member or friend. It’s meant for Veterans with ongoing alcohol problems, to see if family involvement helps them change drinking and stay safe during treatment.
Charleston, South CarolinaAges 21 years+ - NCT05684094Recruiting
Study links sleep, stress, and brain reward in risky drinking
This study looks at how sleep timing and stress affect brain responses related to reward and stress in young adults who drink heavily. It may help researchers understand why some people take bigger alcohol risks and how sleep and stress could be part of safer treatment.
Eugene, OregonAges 18–24 - NCT06501781Recruiting
PUSH: Helping People with HIV and Substance Use
This study tests if a program that encourages positive activities (behavioral activation) can help people with HIV or on PrEP who also use substances improve their health. It focuses on those receiving long-acting injectable medications for HIV prevention or treatment.
Washington D.C., District of ColumbiaAges 18–88 - NCT07783061Recruiting
Study on alcohol reduction to improve heart health
This study tests whether reducing alcohol intake can help lower blood pressure and reduce heart risks in adults who drink above recommended limits. Participants will receive support to cut back on drinking and will be monitored for changes in blood pressure and heart health.
Arlington, TexasAges 26–49 - NCT06550167Recruiting
Nano PSO for brain protection in substance users
This trial tests whether a supplement called Nano PSO can help protect the brain in people who have used methamphetamines, cocaine, and cannabis for at least three years. It looks at effects during the withdrawal period for men currently in residential treatment.
Guadalajara, JaliscoAges 18–50 - NCT07637669Recruiting
Smell and decision-making in people with HIV and substance use
This study looks at how smell and decision-making are affected in people living with HIV and/or substance use disorders. You may join one of four groups based on your HIV status and substance use history, and you will complete smell tests and computer tasks, with an optional MRI.
Baltimore, MarylandAges 18–65 - NCT06324786Recruiting
Brain training to reduce alcohol, cannabis, and tobacco use
This study tests whether a type of brain training called neurofeedback can help people reduce their use of alcohol, cannabis, and cigarettes. If you're an adult who uses all three heavily and have no other mental health conditions, you may be eligible.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for substance use (drugs, alcohol)?
- Yes. Clin2 currently lists 98 recruiting substance use (drugs, alcohol) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance use (drugs, alcohol) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance use (drugs, alcohol) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.