Clinical trials
Tobacco Cessation clinical trials
Below are recruiting tobacco cessation clinical trials, each written for real people, not researchers. We’re tracking 88 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04949464Recruiting
Smoking quit coaching plus lung scans for people with HIV
This study tests a behavior-change program to help people with HIV quit smoking, along with routine low-dose lung CT scans to find warning signs early. It’s a feasibility study, meaning the main goal is to see if the approach is practical and acceptable, and if people can follow through.
La Jolla, CaliforniaAges 45–80 - NCT06583148Recruiting
Smoke-Free Home Program for Tribal Communities
This study aims to help make homes smoke-free in American Indian communities. It tests a program that supports people who smoke or live with a smoker to create a healthier home environment.
Atlanta, GeorgiaAges 18 years+ - NCT05660525Recruiting
Helping rural smokers quit with pharmacist support and nicotine replacement
This study tests a smoking-cessation program delivered through community pharmacies in rural Appalachia. It may help people quit smoking using nicotine replacement (patch or lozenges) plus support from pharmacists.
Charlottesville, VirginiaAges 18 years+ - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT06693700Recruiting
Using an air quality monitor to help make your home smoke-free
This study tests whether an indoor air quality monitor can help people keep their homes smoke-free. It is for MSK patients who currently smoke and want to reduce smoke exposure indoors.
Basking Ridge, New JerseyAges 18 years+ - NCT06678789Recruiting
Testing low vs high nicotine pouches for smokers
This study compares how low and high nicotine pouches affect adult smokers who want to try a tobacco-free option. You'll attend two visits in Charleston to check health markers.
Charleston, South CarolinaAges 21 years+ - NCT05846841Recruiting
Personalized quit-smoking support in primary care
This study tests a personalized tobacco (smoking) treatment plan delivered in primary care to help reduce cravings and smoking. It may help you quit or smoke less using options like nicotine patches/lozenges or varenicline, chosen to fit your needs.
St Louis, MissouriAges 18 years+ - NCT07425119Recruiting
Quit smoking trial for people who smoke a little each day
This study tests a text message program to help people who smoke 1-10 cigarettes most days but not daily quit. It uses cues and reminders sent to your phone to support your quit attempt.
Durham, North CarolinaAges 18 years+ - NCT06432985Recruiting
Smoking Cessation Program for Veterans with Cancer
This study tests a video-based program to help Veterans who smoke and are being treated for cancer or lung cancer screening to quit. If you're a VA patient in San Francisco and currently smoke, you may be able to join.
San Francisco, CaliforniaAges 18 years+ - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT06909500Recruiting
Vaping cessation app for young adults
This trial tests a smartphone app called ACT on Vaping to help young adults quit vaping. It may help you if you are ready to stop using e-cigarettes and want support through a digital tool.
Seattle, WashingtonAges 18–30 - NCT07059377RecruitingPhase 3
Semaglutide to help smokers with diabetes quit
This study tests if the diabetes drug semaglutide can help people with type 2 diabetes stop smoking more easily. Participants will get either semaglutide or a placebo to see if it improves quit rates.
Ottawa, OntarioAges 18 years+ - NCT07199517Recruiting
Helping smokers who aren't ready to quit
This study tests whether switching to a less harmful nicotine product (like a nicotine pouch or e-cigarette) can help people who are not ready to quit smoking reduce their health risks. You would be given a sample of a harm reduction product to try, and researchers will check how it affects your smoking habits.
Philadelphia, PennsylvaniaAges 21 years+ - NCT05746442Recruiting
Interactive quitting messages for Khmer-speaking people with HIV
This trial tests whether interactive, personalized messages can help people who smoke cigarettes quit. It is designed for Khmer-speaking adults living with HIV and aims to support a quit attempt within about two weeks.
Phnom PenhAges 18 years+ - NCT03495024RecruitingPhase 4
Varenicline for quitting smoking in people with schizophrenia
This trial tests whether varenicline helps people with schizophrenia or schizoaffective disorder stop smoking. It also looks at related nervous-system side effects that can happen with some anti-psychotic medicines.
Philadelphia, PennsylvaniaAges 18–75 - NCT06118502Recruiting
Adaptive quit-smoking treatment for early relapse
This trial tests a flexible treatment approach for smokers who want to quit and are at risk of relapsing early. It aims to help you stay smoke-free by adjusting the support you get.
Charleston, South CarolinaAges 21 years+
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Common questions
- Are there clinical trials for tobacco cessation?
- Yes. Clin2 currently lists 88 recruiting tobacco cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.