Clinical trials
Tobacco Cessation clinical trials
Below are recruiting tobacco cessation clinical trials, each written for real people, not researchers. We’re tracking 87 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03912194RecruitingPhase 3
Training to help you quit smoking sooner and feel better
This Phase 3 study tests a quit-training program that teaches how to handle urges and negative feelings when you start cutting back or stopping smoking. You may benefit by improving your chances of quitting and reducing stress during withdrawal.
Birmingham, AlabamaAges 18 years+ - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT05766553Recruiting
Virtual reality mindfulness to reduce cigarette cravings
This trial tests whether guided mindfulness meditation in virtual reality can lower cigarette cravings and help people quit smoking. It may help by reducing urges to smoke during stressful moments.
IteuilAges 18–75 - NCT05814055RecruitingPhase 2
Kava to help quit smoking by easing stress and sleep issues
This Phase 2 study tests whether kava can help people quit smoking, especially by reducing stress and improving sleep during tobacco abstinence. You may be offered kava as part of a quitting support plan and monitored for safety and progress.
Gainesville, FloridaAges 21–75 - NCT06617312RecruitingPhase 2
Cytisinicline and brain response to smoking cues
This study tests how a medicine called cytisinicline (similar to a plant-based stop-smoking aid) affects brain activity when you see or think about smoking. It may help researchers understand how the medicine works, even if you aren't ready to quit right now.
Los Angeles, CaliforniaAges 18–65 - NCT06832085RecruitingPhase 4
Comparing stop-smoking medications for adult smokers in Ontario
This study compares three different stop-smoking treatments—nicotine patches, cytisine, or varenicline—to see which works best. If you want to quit or cut down in the next six months, this could help you find the right medication.
Ottawa, OntarioAges 18 years+ - NCT07292883RecruitingPhase 2
Accelerated TMS for smoking cessation
This trial tests whether a rapid form of brain stimulation (TMS) can help people stop smoking. It is designed for adults who are ready to quit within the next month.
Penetanguishene, OntarioAges 18 years+ - NCT07402642Recruiting
Early Education to Lower Heart Attack Risk Factors
This trial tests if personalized education after a heart attack helps patients lower their future risk of heart problems. It focuses on people who had an emergency procedure to open blocked arteries.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT07491627Enrolling by invitation
Nicotine's effect on gum disease treatment in smokers and non-smokers
This study looks at how smoking and nicotine affect the success of gum disease treatment. It compares results between smokers and non-smokers who have gum disease.
Liège, LiegeAges 18 years+ - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT05733767RecruitingPhase 2
Nurse-led help to quit smoking after heart or lung illness
This Phase 2 study tests a nurse practitioner–led program and medicine plan to help you stop smoking after certain heart or lung conditions. It may help you quit and stay smoke-free, while using lab testing (like breath measurements) to confirm progress.
Springfield, MassachusettsAges 18 years+ - NCT06483412Enrolling by invitation
Healthy Futures: A Vaping Intervention for Teens
This study is testing a program called Healthy Futures that schools can use instead of suspending students caught vaping. The trial wants to see if the program helps teens quit vaping.
Palo Alto, CaliforniaAges 14–18 - NCT05487807RecruitingPhase 1
Quit-smoking program for people with HIV in Uganda and Zambia
This study tests a tailored quit-smoking (tobacco cessation) program for people living with HIV in Uganda and Zambia. It aims to help you reduce or stop tobacco use in a way that fits your needs and local setting.
KampalaAges 18 years+ - NCT07301151Recruiting
Quit smoking study for Black adults in Minnesota
This study tests a smartphone app to help Black adults in Minnesota who smoke quit smoking. You'll use the app to track your progress and get reminders.
Minneapolis, MinnesotaAges 21 years+ - NCT07419425RecruitingPhase 4
Help for Black adults to quit smoking
This study tests a program to help Black adults who smoke quit. It offers support and medication to help you stop smoking.
Phoenix, ArizonaAges 21 years+ - NCT06290869RecruitingPhase 3
Tobacco education and lung scan study
This study tests whether a special health education program, along with a free lung scan, can help long-term smokers quit. You may be able to join if you are a current smoker between 50 and 80 years old and have never had lung cancer.
Washington D.C., District of ColumbiaAges 50–80 - NCT06945120Recruiting
Lung Health Program for Chinese and Korean Smokers
This study is testing a program to help Chinese and Korean adults who smoke to improve their lung health. You may be able to join if you are a current smoker, speak Korean, Mandarin, or English, and live in the U.S.
Boston, MassachusettsAges 18–100 - NCT06582693Recruiting
Tobacco treatment for families through children's hospital
This study offers proactive, personalized help to stop smoking for adults who smoke and have a child who is a patient at Children's Hospital of Philadelphia. It aims to see if this approach works better than usual care.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT07202351Recruiting
Sleep support for quitting smoking or cannabis
This trial tests whether adding sleep-focused help to standard quit-smoking or quit-cannabis therapy improves your chances of success. It is for people who are not already being treated for sleep problems.
Paris, Île-de-France RegionAges 18 years+ - NCT05726045Recruiting
Sleep-based brain training to help you quit smoking
This study tests a way to improve smoking cessation using special sleep-based brain stimulation and memory support. If it works, it may help you stay committed to quitting by strengthening helpful brain learning during sleep.
Mannheim, Baden-WurttembergAges 18–65 - NCT03948893Recruiting
Behavior program to help you quit nicotine
This study tests a structured counseling/behavior treatment to help people who smoke become nicotine-free. If you’re interested in quitting, you may be asked to complete questionnaires and follow a quit plan as part of the research.
Columbia, MissouriAges 18 years+ - NCT07198971Recruiting
Music therapy to help cancer patients quit smoking
This study tests whether adding music therapy sessions can help people with cancer quit smoking more easily. You'll work with a tobacco addiction nurse and a music therapist to see if the music part makes it easier to stick with quitting.
Montpellier, HeraultAges 18 years+ - NCT04949464Recruiting
Smoking quit coaching plus lung scans for people with HIV
This study tests a behavior-change program to help people with HIV quit smoking, along with routine low-dose lung CT scans to find warning signs early. It’s a feasibility study, meaning the main goal is to see if the approach is practical and acceptable, and if people can follow through.
La Jolla, CaliforniaAges 45–80
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Common questions
- Are there clinical trials for tobacco cessation?
- Yes. Clin2 currently lists 87 recruiting tobacco cessation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco cessation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco cessation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.