Clinical trials
Tobacco Use Disorder clinical trials
Below are recruiting tobacco use disorder clinical trials, each written for real people, not researchers. We’re tracking 116 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06989853RecruitingEarly Phase 1
Testing troriluzole for methamphetamine use disorder
This study tests whether a medication called troriluzole can help people who use methamphetamine. If you have methamphetamine use disorder and are not seeking treatment right now, this study may be an option for you.
Lexington, KentuckyAges 18–55 - NCT06853873Enrolling by invitation
Alcohol counseling for safer pregnancies
This trial tests a counseling program to help pregnant women reduce risky alcohol use. The program is designed to support women in making healthier choices for themselves and their baby.
Cape TownAges 18 years+ - NCT06793488RecruitingEarly Phase 1
Anxiety and alcohol use disorder treatment study
This study tests whether a medication called disulfiram (Antabuse) can help people with alcohol use disorder (AUD) feel less anxious when they stop drinking. Researchers will also use brain scans (MRI) to look at how the brain changes during early abstinence.
New York, New YorkAges 21–55 - NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT06544291RecruitingPhase 2
THC and CBD for pain and opioid use disorder
This study tests whether a combination of THC and CBD can help people who have both opioid use disorder and chronic low back pain. You would need to be on a stable dose of methadone and have used cannabis at least once in your life.
New Haven, ConnecticutAges 18–65 - NCT06489782Recruiting
New approach to test alcohol use disorder medications
This study tests a new way to quickly screen medications for alcohol use disorder (AUD). You will have lab sessions where your drinking is monitored to see how different medicines affect your alcohol use.
New Haven, ConnecticutAges 21–65 - NCT06326684RecruitingEarly Phase 1
Testing suvorexant for alcohol use disorder
This study tests whether the sleep medication suvorexant can help people with alcohol use disorder drink less. It involves a short stay where you'll receive either suvorexant or a placebo and then have alcohol.
Lexington, KentuckyAges 21–55 - NCT06310187Recruiting
Little cigar study for daily cigarette smokers
This study looks at how certain chemicals from little cigars affect the body. It may help researchers understand health risks. You must be a daily cigarette smoker who has never smoked little cigars.
Hershey, PennsylvaniaAges 21–65 - NCT06290778Enrolling by invitation
Mental health prevention training for fire fighter trainees
This study tests a program where peers teach emotion regulation skills to help prevent mental health issues in new fire fighters. You would be asked to complete surveys and attend training sessions.
Waco, TexasAges 21 years+ - NCT06136195RecruitingPhase 1
Mavoglurant for alcohol craving in heavy drinkers
This trial tests whether a medication called mavoglurant can reduce alcohol cravings and drinking in people who are heavy drinkers with alcohol use disorder and are not looking for treatment.
New Haven, ConnecticutAges 21–50 - NCT05860699RecruitingPhase 2
Cannabidiol added during inpatient alcohol withdrawal
This trial tests whether cannabidiol (CBD) given during an inpatient alcohol detox helps people stay off alcohol afterward. You would be compared with standard care to see if CBD improves recovery during and after withdrawal.
Créteil, Albert ChenevierAges 18–75 - NCT04903028Recruiting
Brain stimulation to help people quit smoking
This study tests whether a type of brain stimulation (rTMS) can help people stop smoking. It targets brain circuits involved in cravings, aiming to support quitting safely.
Charleston, South CarolinaAges 22–70 - NCT03506867Enrolling by invitation
Test program to help recent smokers in Ottawa or Toronto
This trial offers a health program for people age 16+ who smoked recently and live in Ottawa or Toronto. It aims to help with quitting and follow-up over one year, especially for people facing financial hardship or housing instability.
Ottawa, OntarioAges 16 years+ - NCT06043362Recruiting
Nicotine pouches for daily smokers
This study tests if nicotine pouches can help daily smokers reduce how many cigarettes they smoke. You'll try nicotine pouches, and researchers will track your progress.
Hershey, PennsylvaniaAges 21–70 - NCT06991205Recruiting
Web mind-body program for pain and substance use
This trial tests a web-based mind-body program to help people who have ongoing arm or hand pain and also use substances like alcohol or cannabis. It aims to improve resilience and reduce pain without requiring in-person visits.
Boston, MassachusettsAges 18 years+ - NCT06395415Recruiting
Mobile health program for young adult e-cigarette users
This study tests a mobile health program to help young adults ages 18–26 who use e-cigarettes regularly to reduce or quit. It uses text messages to support you, and you'll need to be interested in changing your vaping habits.
Chicago, IllinoisAges 18–26 - NCT07055204Recruiting
Music-based cognitive training for schizophrenia
This study tests a special music-based training program that uses rhythm, voice, and body movements to help with thinking and memory skills in people with schizophrenia. It might improve how your brain processes information.
BayonneAges 18–60 - NCT06669741Enrolling by invitation
Wearable device for recovery after rotator cuff repair
This study tests whether a special wearable device (Incrediwear) can help you recover faster after rotator cuff repair surgery. It compares recovery outcomes for people who use the device after their shoulder surgery.
Denton, TexasAges 18–75 - NCT07095205RecruitingPhase 4
Nicotine's effect on depression in brain imaging study
This trial uses a special brain scan to see how nicotine might help treat depression. It compares people with depression to healthy volunteers to understand how nicotine affects brain chemistry related to mood.
Stony Brook, New YorkAges 18–65 - NCT05973838Recruiting
Telemedicine support plus recovery coaching for multiple drug use
This study tests whether adding peer recovery support to a phone/video treatment program helps people stay in treatment longer and reduce polysubstance use. It focuses on adults in opioid use disorder care who have used other non-prescribed substances in the last three months.
Washington D.C., District of ColumbiaAges 18 years+
Hear when a new Tobacco Use Disorder trial opens
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Common questions
- Are there clinical trials for tobacco use disorder?
- Yes. Clin2 currently lists 116 recruiting tobacco use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tobacco use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tobacco use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.