Clinical trials
Transtibial Amputation clinical trials
Below are recruiting transtibial amputation clinical trials, each written for real people, not researchers. We’re tracking 12 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05989243Recruiting
Improving prosthetic socket fit for veterans with leg amputations
This trial tests a new way to make prosthetic sockets fit better for veterans with a leg amputation below or above the knee. If you can walk with your prosthesis, even if it's limited to curbs or stairs, you may be able to join.
Aurora, ColoradoAges 18–65 - NCT07685496Recruiting
How shoes affect walking for below-knee amputees
This study looks at how different types of footwear affect walking in people with a below-knee amputation. If you use a specific energy-returning prosthetic foot and can walk without aids, you may be able to join and help improve understanding of what shoes work best.
Manchester, Greate ManchesterAges 18–65 - NCT07592325Recruiting
Testing a New Flexible Prosthetic Socket for Below-Knee Amputees
This trial compares a new flexible prosthetic socket design to the rigid socket you currently wear. The goal is to see if the new socket is more comfortable, easier to put on, and improves how well your prosthetic leg works for daily activities.
ClamartAges 18 years+ - NCT07263945RecruitingPhase 1
Prosthetic Foot Stiffness and Walking in Below-Knee Amputation
This study tests how different prosthetic foot stiffness levels affect walking, balance, and comfort in people with a below-knee amputation who use either a bone-anchored implant or a traditional socket. Participating may help match the right foot to your needs and improve your daily mobility.
Aurora, ColoradoAges 18 years+ - NCT03995238Recruiting
Gait training for veterans with leg amputations
This study tests a walking rehabilitation plan to improve how you walk after a lower-leg amputation. It may help if your walking steps are uneven and you have diabetes and/or circulation problems in your legs.
Aurora, ColoradoAges 40–89 - NCT07195461RecruitingEarly Phase 1
Magnetic beads helping control a robotic leg
This trial tests a new system that uses tiny magnetic beads to help a robotic leg move more naturally. It aims to improve function for people who need a below-knee amputation or already have one that needs fixing.
Boston, MassachusettsAges 22–65 - NCT05124652Recruiting
Testing a prosthetic socket that adjusts automatically
This trial is testing a prosthetic socket that can automatically adjust to help fit better and feel more comfortable. It may help people with below-knee (transtibial) amputations who currently struggle with socket fit or comfort.
Seattle, WashingtonAges 18 years+ - NCT05287646Recruiting
Track how your residual limb moves while walking with a prosthesis
This study uses a special X-ray and markers to measure how your leg and skin move inside your prosthetic socket while you walk. It may help researchers better understand fit and comfort for people with transtibial (below-knee) amputations.
New York, New YorkAges 18 years+ - NCT06308562Recruiting
Fuzzy sock after leg amputation to help healing
This trial tests a fuzzy compression sock worn on the leg after amputation below the knee (transtibial amputation). The goal is to see if it helps the wound heal better in people with peripheral artery disease.
Rochester, MinnesotaAges 18 years+ - NCT07216183RecruitingPhase 1
Skin sensor study for lower leg amputees
This study tests a new wireless skin sensor that sticks to your residual limb (the part of your leg below the knee where you wear your prosthetic). The goal is to track how your skin is doing inside the socket. If you qualify, you'll visit North Carolina State University to try the sensor and be photographed during research activities.
Raleigh, North CarolinaAges 18–75 - NCT06636136Recruiting
Bone-anchored implant for below-knee amputation
This trial tests a metal implant that connects directly to your shin bone, replacing the need for a socket. It's for people with below-knee amputations who have trouble using a regular prosthetic leg.
Bethesda, MarylandAges 22–65 - NCT06648798Recruiting
Comparing a new fast-fit prosthetic leg to your current one
This trial is testing a new quick-to-make, custom below-knee prosthetic leg (called the UniLeg). It compares how well it works for daily walking versus your current prosthetic. The goal is to see if the new leg can be made faster and fit better, helping you stay active.
La Jolla, CaliforniaAges 18–75
Hear when a new Transtibial Amputation trial opens
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Common questions
- Are there clinical trials for transtibial amputation?
- Yes. Clin2 currently lists 12 recruiting transtibial amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a transtibial amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a transtibial amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.