Clinical trials
Lower Limb Amputation clinical trials
Below are recruiting lower limb amputation clinical trials, each written for real people, not researchers. We’re tracking 74 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07831707Recruiting
Walking and attention study for people with one leg amputation
This study looks at how attention and surroundings affect walking in people with a lower leg amputation. It may help improve mobility and independence.
Richmond, VirginiaAges 18 years+ - NCT07817381Recruiting
Resistance and loading exercise for bone health
This trial tests a supervised exercise program with weights and jumping activities to improve bone health in males with one leg amputated below the knee. If you're already using a prosthetic leg and walking well, this study might help strengthen your bones.
LoughboroughAges 18–55 - NCT07706452Recruiting
Balance Training for People with a Prosthetic Leg
This study tests a special balance training program for people who use a prosthetic leg after losing a leg due to injury. The program combines balance exercises with a second task (like talking or counting) to improve walking and stability in daily life.
Gaza, Gaza StripAges 18 years+ - NCT06638723Recruiting
Better walking after leg amputation
This study tests a new training program to help improve walking and balance for people with one leg amputation. You'll visit UNLV six times for practice sessions.
Las Vegas, NevadaAges 18 years+ - NCT07685496Recruiting
How shoes affect walking for below-knee amputees
This study looks at how different types of footwear affect walking in people with a below-knee amputation. If you use a specific energy-returning prosthetic foot and can walk without aids, you may be able to join and help improve understanding of what shoes work best.
Manchester, Greate ManchesterAges 18–65 - NCT07613502Recruiting
Bio Leg: Advancing Mobility (BAM)
This study tests a new prosthetic leg designed to help people with above-knee amputations walk better. It may be a good fit if you already use a C-leg and can walk with a single point cane.
Jacksonville, FloridaAges 40–70 - NCT07592325Recruiting
Testing a New Flexible Prosthetic Socket for Below-Knee Amputees
This trial compares a new flexible prosthetic socket design to the rigid socket you currently wear. The goal is to see if the new socket is more comfortable, easier to put on, and improves how well your prosthetic leg works for daily activities.
ClamartAges 18 years+ - NCT07486063RecruitingEarly Phase 1
Motorized leg prosthetics for above-knee amputees
This study tests whether a motorized (powered) prosthetic knee and ankle can help people with above-knee amputations walk better. If you already use a mechanical or microprocessor-controlled leg, you may be able to try a new powered version.
Salt Lake City, UtahAges 18–80 - NCT07448350Recruiting
TENS therapy for better sensation after leg amputation
This study tests if a gentle electrical stimulation method called TENS can help people who have lost a leg below or above the knee feel more natural sensations in their missing limb and reduce phantom limb pain.
Rome, RomeAges 18–80 - NCT07420192Recruiting
A study on nerve surgery for pain after leg amputation
This trial tests a surgery called RPNI to treat painful nerve growths (neuromas) in people who have lost a leg. The goal is to reduce severe pain and improve the ability to use a prosthetic limb.
Ankara, AnkaraAges 18–70 - NCT07387744Recruiting
Mobility study for people with leg amputation
This study looks at how people with a leg amputation get around both walking and using a wheelchair or scooter. It aims to understand community mobility to help improve care and devices.
Richmond, VirginiaAges 18–85 - NCT07384689Recruiting
Study of leg tissue in non-traumatic amputation patients
This study looks at the tissue environment in the legs of patients who need amputation due to non-traumatic causes, like poor blood flow or infection. Understanding the tissue better might help improve healing for future patients.
Aarhus NAges 18 years+ - NCT05818410Recruiting
Brain and tech training after below-knee leg loss
This study looks at how your brain works with assistive technology after losing a leg below the knee. It may help researchers improve how prosthetic devices feel and function by measuring brain and movement signals during training.
BrusselsAges 18–65 - NCT06667739Recruiting
Promoting physical activity after leg amputation
This study tests a program to help people who have lost a leg due to diabetes or blood vessel disease become more active. It uses coaching and online modules to support your progress.
Toronto, OntarioAges 18 years+ - NCT07324109Recruiting
Testing a system for phantom limb pain after leg amputation
This trial is testing a system called Suralis to see if it can help evaluate phantom limb pain — pain that feels like it's coming from a missing leg. It's for people who have had a leg amputated below or above the knee, use a prosthetic regularly, and have daily pain scoring at least 3 out of 10.
Wiesbaden, HesseAges 18 years+ - NCT07266077Recruiting
A study of a slope-adapting prosthetic foot for Veterans
This study tests a special prosthetic foot that adapts to slopes (like hills or ramps) to help Veterans with below-knee amputations walk more easily. You would need to visit the Minneapolis VA and use a special foot for a while.
Minneapolis, MinnesotaAges 18–89 - NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT07214493Recruiting
Study of a prosthetic foot with adjustable heel height
This trial tests a prosthetic foot that lets you adjust the heel height so you can comfortably walk in different shoes or barefoot. It is for people with a leg amputation who already use a certain type of prosthetic foot and want more flexibility in their footwear.
ConcarneauAges 18 years+ - NCT07191795Recruiting
Using phantom sensations from socket changes as feedback while walking
This trial tests whether changing how your prosthetic socket fits can create helpful phantom limb sensations that improve your walking. It may help people with major lower-limb amputations walk more naturally.
NancyAges 18 years+ - NCT07094074Recruiting
Walking and balance study for leg amputees
This study looks at how people who have lost a leg walk, balance, and move with an artificial limb (prosthesis). Participating helps researchers understand how to improve prosthetic devices and rehabilitation.
DijonAges 18 years+ - NCT07076602Recruiting
Walking and energy use in children with leg amputations
This study looks at how children with a leg amputation walk and how much energy they use when walking. It aims to better understand gait and energy use to improve care and prosthetic fitting.
BerckAges 7–17 - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100 - NCT06987019Recruiting
Measuring balance in people with below-knee amputation
This study tests a new way to measure how well people with a below-knee amputation keep their balance while wearing their prosthesis. It aims to see if this measurement is reliable and accurate, which could help improve future care.
New York, New YorkAges 18 years+ - NCT06937242Recruiting
Testing a smarter prosthetic knee for safer walking
This study tests whether a microprocessor-controlled knee can reduce falls in people who walk limited distances. If you use a regular mechanical knee and have a moderate activity level, this trial might help you walk more safely.
Austin, TexasAges 18 years+
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Common questions
- Are there clinical trials for lower limb amputation?
- Yes. Clin2 currently lists 74 recruiting lower limb amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.