Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 140 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT06419920Recruiting
Prosthetic performance enhancement trial
This study tests whether a new prosthetic foot can help people with a lower-limb amputation walk better. You will use your current foot and the new foot, and we will measure how well you walk.
Las Vegas, NevadaAges 18 years+ - NCT07011420Recruiting
Testing different prosthetics controls for arm amputees
This trial tests how different numbers and types of muscle signals (myoelectric) affect control of a prosthetic hand and wrist. It aims to find the best setup for people with a below-elbow amputation who have used a myoelectric prosthetic before.
Chicago, IllinoisAges 18 years+ - NCT03882073Recruiting
Upper arm amputation rehab study to improve hand control and feel
This trial tests a new approach for rehabilitation after an upper-limb amputation to help improve your ability to intentionally control a prosthetic and regain a sense of position (“proprioception”). You may be considered if you are planning an elective upper-arm or below-elbow amputation and can safely have surgery and follow up closely.
Bethesda, MarylandAges 18–65 - NCT06737770Recruiting
Bone-anchored leg implant study
This study tests a bone-anchored implant (directly attached to the thighbone) for people with a single leg amputation above the knee. It aims to see if this implant helps with pain, movement, and skin issues caused by a traditional socket prosthetic.
BolognaAges 18–65 - NCT04855214Recruiting
Sharing experiences using an upper-limb prosthesis
This study looks at what it feels like to use an upper-limb prosthesis over time. It may help researchers understand user experiences and improve prosthesis support and training.
Cleveland, OhioAges 18 years+ - NCT04953364Recruiting
Tech-based self-management support after a leg amputation
This study tests a technology-based program to help people manage rehabilitation after a lower-limb amputation. It may help by giving structured support for day-to-day care and prosthesis use.
Vancouver, British ColumbiaAges 50 years+ - NCT05981664Recruiting
Can adaptive gaming help kids with arm differences?
This study explores whether playing video games with adapted controls can help children aged 7 to 17 who have a missing or different arm or hand. It tests how fun and useful these games are for improving movement and daily life.
Winnipeg, ManitobaAges 7–17 - NCT06194838Recruiting
Mechanical vs. powered knee for above-knee amputees
This study compares a non-powered (mechanical) knee to a powered (battery-assisted) knee for people with above-knee amputations who walk at a moderate level (K2). It will help find out which knee type works better for your daily activities and mobility.
Austin, TexasAges 18 years+ - NCT06433648Recruiting
Powered knee study for above-knee amputee walkers
This study looks at how a powered (motorized) prosthetic knee joint affects walking in people with one above-knee amputation. It aims to find out if the powered knee makes walking easier or more natural.
Chicago, IllinoisAges 18–95 - NCT06937242Recruiting
Testing a smarter prosthetic knee for safer walking
This study tests whether a microprocessor-controlled knee can reduce falls in people who walk limited distances. If you use a regular mechanical knee and have a moderate activity level, this trial might help you walk more safely.
Austin, TexasAges 18 years+ - NCT07175675Recruiting
Surgery versus dressing for single finger amputations
This trial compares two treatments for a single finger amputation: surgery (reattachment) versus a special dressing that protects the wound while it heals on its own. It is for adults who are able to communicate in Finnish.
TampereAges 18 years+ - NCT07324109Recruiting
Testing a system for phantom limb pain after leg amputation
This trial is testing a system called Suralis to see if it can help evaluate phantom limb pain — pain that feels like it's coming from a missing leg. It's for people who have had a leg amputated below or above the knee, use a prosthetic regularly, and have daily pain scoring at least 3 out of 10.
Wiesbaden, HesseAges 18 years+ - NCT01293214Recruiting
Transplanting new tissue for multiple amputated limbs
This trial studies whether a transplant of tissue and blood vessels can improve function after limb amputations when prosthetic devices have not worked. It requires long-term medicines to prevent rejection, close follow-up, and intensive rehabilitation.
Boston, MassachusettsAges 18–60 - NCT05989243Recruiting
Improving prosthetic socket fit for veterans with leg amputations
This trial tests a new way to make prosthetic sockets fit better for veterans with a leg amputation below or above the knee. If you can walk with your prosthesis, even if it's limited to curbs or stairs, you may be able to join.
Aurora, ColoradoAges 18–65 - NCT06667739Recruiting
Promoting physical activity after leg amputation
This study tests a program to help people who have lost a leg due to diabetes or blood vessel disease become more active. It uses coaching and online modules to support your progress.
Toronto, OntarioAges 18 years+ - NCT05768802Recruiting
Testing a forearm implant that records muscle signals for prosthetic use
This study tests a small implant that records signals from your forearm muscles in people with a specific type of arm amputation. It aims to help improve how well prosthetic hands can be controlled using muscle activity.
Pittsburgh, PennsylvaniaAges 22–70 - NCT07387744Recruiting
Mobility study for people with leg amputation
This study looks at how people with a leg amputation get around both walking and using a wheelchair or scooter. It aims to understand community mobility to help improve care and devices.
Richmond, VirginiaAges 18–85 - NCT05437562Recruiting
Trial compares recovery after lower-leg amputation in Veterans
This trial looks at outcomes after a below-knee (lower-leg) amputation in Veterans. It focuses on people who have blood flow likely to heal and who plan to join rehabilitation to walk again with a prosthesis.
Decatur, GeorgiaAges Any age - NCT02395497RecruitingPhase 2/Phase 3
Penile transplant trial using immune-suppressing medicines
This study tests whether a donated penis can be successfully transplanted using medicines that calm the immune system to prevent rejection. It also looks at safety and recovery of function in men with severe penile loss from injury, cancer surgery, or birth conditions.
Baltimore, MarylandAges 18–69 - NCT06886295Recruiting
New ways to control an advanced prosthetic hand
This study is testing new, more natural ways to control an advanced prosthetic hand for people with below-elbow amputations. It may help you move the prosthetic more easily and intuitively.
Bologna, BoAges 18–65 - NCT07685496Recruiting
How shoes affect walking for below-knee amputees
This study looks at how different types of footwear affect walking in people with a below-knee amputation. If you use a specific energy-returning prosthetic foot and can walk without aids, you may be able to join and help improve understanding of what shoes work best.
Manchester, Greate ManchesterAges 18–65 - NCT03260400Recruiting
Muscle and nerve implants to improve bionic arm control
This study tests a new approach that uses small nerve and muscle grafts along with temporary electrodes to help people with an above-wrist arm amputation get better control of a bionic arm. If it works, it could make prosthetics feel more natural and easier to use.
Ann Arbor, MichiganAges 22–75 - NCT07265154Recruiting
Gait training with AI for above-knee amputees
This trial tests a new way to help people with above-knee amputations improve how they walk, using artificial intelligence to guide their gait training. It may help you walk more naturally and safely.
Banhā, BenhaAges 16–50
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Amputation trials by city
Studies with a site in or near these metro areas.
Amputation trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 140 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.