Urinary Tract Infections in Children clinical trials

Stopping antibiotics early versus completing the full course

This study compares two ways of giving antibiotics to children: stopping when symptoms feel better versus finishing all the prescribed doses. Researchers want to see if stopping early is safe and works just as well, which could help reduce unnecessary antibiotic use.

Drug safety study for children already on certain medicines

This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.

Study digestive side effects after antibiotics for UTIs in kids

This study looks at possible effects on a child’s digestive system after standard antibiotics are used to treat a fever-related urinary tract infection (UTI). It may help doctors better understand what side effects to expect and how to manage them.

Fosfomycin for drug-resistant bladder infections in children

This trial tests whether fosfomycin works better than the usual treatment for children with urine infections caused by antibiotic-resistant germs. It may help by using an antibiotic choice that can still work when common oral options may fail.

Ultrasound in children after a first bladder infection

This trial studies whether doing an ultrasound scan after a child’s first febrile urinary tract infection (UTI) is useful. The goal is to see which children might need further attention based on the scan.

Antibiotics by mouth only for young babies with urine infection

This trial studies whether giving antibiotics by mouth alone is enough to treat a urinary tract infection (UTI) in very young babies. It may help reduce the need for stronger or more invasive antibiotic approaches if you meet the study’s stability and urine-test requirements.

Single IV antibiotic dose for complicated UTIs in children

This trial studies whether giving just one dose of an intravenous (IV) antibiotic can safely treat complicated urinary tract infections (UTIs) in children. It aims to see if this shorter approach works as well as standard treatment while still preventing complications.

Comparing two types of single-use ureteroscopes for kidney stones in children

This trial compares two types of disposable flexible ureteroscopes to see which works better for removing kidney stones in children. If your child has a single kidney stone or multiple stones that add up to less than 20 mm, this study may help guide better treatment.

Bladder training device for children with urinary problems

This trial tests a device that helps children with nighttime bedwetting, daytime urine leaks, or frequent urgent urination by teaching them to relax and control their bladder. It aims to improve symptoms without medication.

Can a breast-milk sugar supplement prevent colds and stomach bugs?

This study tests a chewable supplement made from a natural sugar found in breast milk (2'-fucosyllactose) to see if it helps prevent colds and stomach bugs in young children who attend daycare or school. It is for healthy children between 1 and 4 years old.

Antibiotics and symptom tracking in children

This study looks at how children with common infections feel while taking antibiotics. The goal is to better understand symptom patterns during treatment.

Shorter antibiotics for children with common infections

This study tests whether shorter courses of antibiotics are as effective as longer ones for children hospitalized with pneumonia, skin infections, or urinary tract infections. It may help children get back to normal faster and reduce side effects.

Brain activity study in children with overactive bladder

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. It uses MRI scans to understand how the brain controls the bladder, which could lead to better treatments.

Sacituzumab govitecan with or without atezolizumab for rare GU cancers

This trial is testing a drug called sacituzumab govitecan, sometimes combined with atezolizumab (an immunotherapy), for rare cancers of the bladder, urinary tract, kidney, or penis. The goal is to see if these treatments work well for people whose cancers have not responded to other options.

A Study to Investigate PK, Safety, Tolerability of Cefepime-enmetazobactam in Pediatric Participants With cUTI

A study on salt-wasting in children with urinary tract issues

This study looks back at medical records of young children who had a condition called pseudohypoaldosteronism (a temporary salt-wasting problem) along with a urinary tract malformation or infection. Researchers want to learn more about this condition to help doctors recognize and treat it better.

Medicines for daytime wetting in children

This study tests two medicines (solifenacin and mirabegron) alone and together to see which works best for children with daytime wetting. It is for children ages 5 to 14 who still have accidents after trying non-drug treatments.

Microbiota study in children with and without overactive bladder

This research study compares the bacteria in urine, around the genital area, and in stool between children with overactive bladder (frequent urgent need to urinate) and healthy children. The goal is to understand if differences in these bacteria might explain why some children develop overactive bladder.

Durvalumab plus chemo before surgery for upper tract cancer

This trial tests whether adding an immunotherapy drug (durvalumab) to chemotherapy before surgery can improve outcomes for people with high-grade upper tract urothelial cancer. It compares different treatment approaches based on whether a patient can receive cisplatin chemotherapy.

Raphamin for colds in children ages 3 to 12

This trial tests if Raphamin can safely treat common cold symptoms in children. It is for kids who have had cold symptoms for less than 24 hours and have a fever of at least 100°F with other symptoms like stuffy nose or sore throat.