Treatment
Comparator clinical trials
We’re tracking 1,730 recruiting studies that include Comparator, each written for real people, not researchers, below.
Recruiting studies
- NCT04209127Recruiting
Microwave vs uterine artery embolization for adenomyosis symptoms
This study compares two ways to treat adenomyosis to see which works better for symptom relief. You may be offered either microwave treatment or uterine artery embolization (a procedure that reduces blood flow to the affected area).
StockholmAges 30–55 - NCT04222062RecruitingPhase 2
Compare Gliadel implant versus focused brain radiation
This Phase 2 study compares two ways to treat brain metastases: a Gliadel wafer placed during planned surgery versus focused stereotactic radiosurgery. It aims to see which approach works better and is safer for people with a limited number of brain tumor spots.
Detroit, MichiganAges 18 years+ - NCT04234191RecruitingPhase 2
Test faster buprenorphine/naloxone start versus usual start for opioid use disorder
This Phase 2 study compares a rapid way to start buprenorphine/naloxone versus the standard way, for people with opioid use disorder. It aims to see whether the faster start is safe and works well enough to help people begin treatment sooner.
Vancouver, British ColumbiaAges 19 years+ - NCT04239573Recruiting
Compare pancreatic cyst checkup programs and test markers
This study compares different ways to monitor pancreatic cysts and also measures blood or other test markers to see which approach is more helpful. It may help patients by finding the safest, most effective way to track certain cysts that could otherwise be hard to manage.
Birmingham, AlabamaAges 50–75 - NCT04293562RecruitingPhase 3
Testing targeted drugs plus chemo for newly diagnosed AML
This study compares standard chemotherapy to chemotherapy plus CPX-351 and/or gilteritinib in children and young adults newly diagnosed with AML. It aims to see whether adding these targeted treatments improves outcomes, especially for certain gene changes like FLT3.
Birmingham, AlabamaAges Up to 21 years - NCT04295863RecruitingPhase 1
Test different dosing schedules for two immunotherapy drugs
This early trial compares how often two immune system medicines—nivolumab and pembrolizumab—are given for advanced or metastatic cancers. It aims to see which dosing interval is workable and safe for people needing treatment.
Chicago, IllinoisAges 18 years+ - NCT04309487Recruiting
Check shunt blockage using ShuntCheck versus a scan
This study tests whether a device called ShuntCheck can accurately tell if a VP (ventriculoperitoneal) shunt is blocked in people with normal pressure hydrocephalus. If it works well, it may help doctors find shunt problems faster and more safely.
Tampa, FloridaAges 40 years+ - NCT04314219RecruitingPhase 3
Preventing GVHD after leukemia stem cell transplant
This Phase 3 study tests whether giving post-transplant cyclophosphamide can better prevent a dangerous immune complication called GVHD compared with the usual standard medicines. You may be eligible if you are in remission from acute leukemia and planning a fully matched related-donor stem cell transplant.
RiyadhAges 14–65 - NCT04330846Recruiting
Study of new narrowing in Crohn’s treated with two approaches
This study looks at treatments for a new (de novo) narrow area in the bowel from Crohn’s disease. It aims to see which treatment works better at relieving blockage-type symptoms for the safest, most effective option.
Badalona, BarcelonaAges 18–80 - NCT04332822RecruitingPhase 3
Testing mini-CHOP versus adding polatuzumab for lymphoma
This study compares two lymphoma treatments: mini-CHOP alone versus mini-CHOP plus a drug called polatuzumab vedotin. It aims to see which regimen works better and is tolerable for older or frail people with certain types of aggressive B-cell lymphoma.
AlburyAges 75 years+ - NCT04333537RecruitingPhase 2/Phase 3
Sentinel node biopsy versus standard neck surgery for early mouth cancer
This trial compares two ways of checking whether early oral cavity squamous cell cancer has spread to neck lymph nodes. It tests whether sentinel lymph node biopsy can find spread as well as standard neck dissection, while potentially reducing more extensive surgery for some people.
Birmingham, AlabamaAges 18 years+ - NCT04339699Recruiting
PFO closure comparison trial for cryptogenic stroke
This trial studies ways to close a patent foramen ovale (PFO) to help prevent another stroke in people whose prior stroke had an unknown cause. If you qualify, you may receive one of the PFO closure approaches the study is comparing.
Tucson, ArizonaAges 18–60 - NCT04345081Recruiting
Compare two breast surgery skin-sparing methods and recovery
This trial compares two types of mastectomy (with skin and nipple options) and implant reconstruction to see which gives better cosmetic results, comfort, and satisfaction. You may help doctors learn which approach leads to a better quality of life after surgery.
BudapestAges 18–65 - NCT04356235Recruiting
Comparing immediate vs delayed breast implant reconstruction results
This study compares two timing options for rebuilding the breast with implants, looking at cosmetic results, quality of life, and patient satisfaction. It may help you understand which approach could fit you better and what to expect over follow-up time.
BudapestAges 18–65 - NCT04365751Recruiting
Microwave ablation versus surgery for liver cancer
This trial compares two ways to treat hepatocellular carcinoma (a type of liver cancer): microwave ablation and laparoscopic hepatectomy (keyhole liver surgery). It may help find which option works better for tumor control and recovery in people with limited, non-spread cancer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04375033RecruitingPhase 4
Oral versus injection buprenorphine for opioid use disorder
This trial compares taking buprenorphine by mouth versus as an injection for opioid use disorder. It aims to see which option helps people stay on treatment and reduces opioid use over about a year.
Tuscaloosa, AlabamaAges 18 years+ - NCT04429217Recruiting
Immediate versus delayed weight-bearing after ankle surgery
This trial compares two rehab plans after ankle fracture surgery: putting weight on the ankle right away versus waiting. It aims to see which approach is safer and better for healing and recovery.
LuganoAges 18–70 - NCT04460989Recruiting
Compare knee replacement satisfaction by implant type
This study asks how satisfied people are after knee replacement, comparing different knee implant types. You may help researchers understand which implant approach leads to better patient experience.
LyonAges 18 years+ - NCT04511013RecruitingPhase 2
Trial for BRAF-mutant melanoma spread to the brain
This Phase 2 study tests whether a 3-drug plan (encorafenib + binimetinib + nivolumab) works better than ipilimumab + nivolumab for melanoma that has spread to the brain. If you qualify, you’ll get either treatment and have frequent brain scans to track how well it controls the tumors.
Birmingham, AlabamaAges 18 years+ - NCT04525989Recruiting
Short-course proton vs photon radiation before rectal surgery
This study compares two types of pre-surgery radiation—protons versus standard photons—in people with high-risk rectal cancer. The goal is to shrink and control the tumor while safely getting you ready for surgery, and to see which approach works better.
Stockholm, SolnaAges 18 years+ - NCT04529785Recruiting
Tested added ethanol vein treatment during repeat atrial fibrillation ablation
This trial compares two ways to help stop atrial fibrillation during a repeat procedure: standard vein isolation only versus standard isolation plus an added medicine (ethanol) into the vein of Marshall. It aims to see whether the added step improves results when atrial fibrillation returns after a previous successful treatment.
Bruges, Please SelectAges 18 years+ - NCT04546399RecruitingPhase 2
Blinatumomab with or without nivolumab for first relapse ALL
This study compares blinatumomab alone versus blinatumomab plus nivolumab in young people whose B-cell ALL has returned for the first time. It aims to see whether adding nivolumab improves control of the leukemia after relapse.
Birmingham, AlabamaAges 1–30 - NCT04581447RecruitingPhase 3
Metformin to help prevent diabetes returning after weight surgery
This Phase 3 study tests whether adding metformin after gastric bypass or sleeve surgery can help you stay free of diabetes for longer. It compares metformin plus standard care versus standard care alone.
AmiensAges 18–70 - NCT04590560Recruiting
Best timing for breast screening in women ages 45–49 and 70–74
This study looks at the best time interval for breast cancer screening (mammograms) for women in two age groups. The goal is to reduce missed cancers while avoiding unnecessary tests.
Meldola (FC), FCAges 45–49
Common questions
- Are there clinical trials studying Comparator?
- Yes. Clin2 currently lists 1,730 recruiting studies that include Comparator, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Comparator trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Comparator an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Comparator or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.