Treatment
Comparator clinical trials
We’re tracking 1,702 recruiting studies that include Comparator, each written for real people, not researchers, below.
Recruiting studies
- NCT04246138Recruiting
Robot-assisted knee replacement alignment: best function
This trial compares two types of robot-guided knee replacement alignment to see which one helps people do everyday activities better after surgery. If you have “wear-and-tear” knee arthritis, you may be offered one of the two surgical alignment approaches as part of a study.
Hull, East YorkshireAges 18–90 - NCT04227314RecruitingPhase 3
Apremilast vs placebo for severe recurrent mouth ulcers
This Phase 3 trial tests whether apremilast can reduce severe, recurring mouth ulcers compared with an inactive placebo. It aims to improve ulcer frequency and pain while carefully checking safety.
AmiensAges 18 years+ - NCT04251052Recruiting
Compare two surgeries to lower ovarian cancer risk in BRCA1 carriers
This study compares two risk-reducing surgery plans for people with a BRCA1 genetic change to see which approach helps lower ovarian cancer risk. You may be asked to have the study procedure sooner or later depending on your chosen plan.
Birmingham, AlabamaAges 35–50 - NCT04222062RecruitingPhase 2
Compare Gliadel implant versus focused brain radiation
This Phase 2 study compares two ways to treat brain metastases: a Gliadel wafer placed during planned surgery versus focused stereotactic radiosurgery. It aims to see which approach works better and is safer for people with a limited number of brain tumor spots.
Detroit, MichiganAges 18 years+ - NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Phoenix, ArizonaAges 18 years+ - NCT04095598Recruiting
CT scan with stress tests for unstable ankle ligaments
This study tests whether a special CT scan with gentle stress maneuvers can better find ankle ligament injury (syndesmotic instability) after a sprain. If you had a recent ankle sprain and exam suggests this specific injury, the scan may help guide the right treatment.
São Paulo, São PauloAges 18 years+ - NCT04008121RecruitingEarly Phase 1
Testing an eye imaging drug during retinal blood-vessel photos
This early safety study tests how well and how safely an investigational dye (MB-102) works during a special eye imaging test of retinal and choroidal blood vessels. It compares it to the commonly used fluorescein dye and may help doctors refine future eye imaging approaches.
Ann Arbor, MichiganAges 18 years+ - NCT03984591Enrolling by invitationPhase 4
Compare spironolactone vs eplerenone for heart failure patients
This study uses Denmark’s heart failure registry to compare two common tablet medicines—spironolactone and eplerenone—for people with symptomatic systolic heart failure. It aims to see which one leads to better health outcomes over time.
CopenhagenAges Any age - NCT03803332Recruiting
Therapies for PTSD from military sexual trauma compared for adults
This trial compares two types of talk therapy to treat PTSD caused by military sexual trauma. It aims to see which therapy helps symptoms better and how well people can complete weekly outpatient sessions.
New York, New YorkAges 18–85 - NCT03550391RecruitingPhase 3
Surgery-like brain radiation vs avoiding the memory center
This trial compares two ways of giving radiation to the brain for people with 5 or more brain metastases: focused stereotactic radiosurgery, or a whole-brain approach that tries to spare the memory area (with memantine). It aims to see which method better protects thinking and memory while still treating the tumors.
Tucson, ArizonaAges 18 years+ - NCT03619850RecruitingPhase 3
Ferumoxytol vs iron sucrose for child kidney anemia
This study compares two IV iron treatments—ferumoxytol and iron sucrose—to treat iron deficiency anemia in children with chronic kidney disease. It aims to see which option works better and is safe, and also to learn how each medicine behaves in the body.
Hollywood, FloridaAges 2–17 - NCT03687710Enrolling by invitation
Alzheimer’s registry for people with memory concerns or risk
This is a research registry that helps doctors compare how different memory and Alzheimer’s risk groups change over time. It may help researchers learn which people are more likely to develop Alzheimer’s and how to better track early changes.
New York, New YorkAges 18–99 - NCT03706027Recruiting
Compare two radiation timing plans for early lung cancer
This trial tests whether two different schedules (timing) of radiation have different side effects in people with early-stage non-small cell lung cancer. It may help reduce or better understand treatment toxicity while still treating the cancer.
Rochester, New YorkAges 18 years+ - NCT03300141Enrolling by invitation
Robotic arm training with visual feedback after stroke
This trial tests a robotics-based training program that helps people practice reaching with both the arm and hand, using real-time visual guidance. It may help improve how smoothly and accurately you can reach after stroke.
Chicago, IllinoisAges 18 years+ - NCT03254667Enrolling by invitation
Track outcomes in adults with moderate-to-severe psoriasis
This study keeps track of how people with moderate-to-severe psoriasis do over time while using Siliq or other approved treatments. It may help researchers understand how treatments compare in real life.
Bridgewater, New JerseyAges 18–99 - NCT03184545RecruitingPhase 3
Electrical stimulation vs physical therapy for knee pain
This trial compares an electrical stimulation treatment to standard physical therapy for people with long-lasting pain in the front of the knee. It aims to see which approach better improves symptoms and function for patellofemoral pain syndrome.
New York, New YorkAges 18–40 - NCT03248310Recruiting
Surgery vs non-surgical care for lymphedema quality of life
This study compares how people feel day to day (quality of life) after either surgery or non-surgical care for lymphedema. It may help doctors understand which approach improves comfort, function, and overall well-being.
Harrison, New YorkAges 18–80 - NCT02507141Recruiting
Check oral cancer images during surgery using a special camera
This study tests whether a special in-mouth imaging tool can capture clear images of oral cancer before surgery, compared with the final lab diagnosis from tissue (pathology). If the images match the pathology, it could help doctors better assess tumors using real-time imaging.
Basking Ridge, New JerseyAges 18 years+ - NCT02422875Enrolling by invitation
Study of immune markers in autoimmune disease and lupus
This study looks at blood and immune cell markers (autoantibodies and immune cell “signatures”) to better understand autoimmune conditions, including lupus. It may help researchers identify which markers are linked to disease and how immune cells respond after vaccination.
Atlanta, GeorgiaAges 18 years+ - NCT02416388RecruitingPhase 2/Phase 3
Trial for AML treatments and preventing graft-versus-host disease
This trial tests different chemotherapy induction, consolidation (follow-up treatment), and strategies to prevent complications after an allogeneic stem cell transplant. It aims to improve overall survival and reduce serious transplant side effects like graft-versus-host disease (GVHD).
AmiensAges 18–61 - NCT01530373RecruitingPhase 2
Solifenacin vs clonidine to reduce breast cancer hot flashes
This trial compares two medicines—solifenacin and clonidine—to see which one better reduces hot flashes in people taking hormone-blocking cancer medicines. If you have frequent hot flashes, joining could help researchers find an effective option for symptom relief.
Little Rock, ArkansasAges 18 years+ - NCT00898313Recruiting
Study looks for cancer clues in people at high risk for lung cancer
This study enrolls adults who are being checked for possible lung cancer because of concerning symptoms or a high-risk situation. It aims to find molecular (cell/DNA-related) predictors that may help doctors better recognize lung cancer earlier.
Nashville, TennesseeAges 18 years+
Common questions
- Are there clinical trials studying Comparator?
- Yes. Clin2 currently lists 1,702 recruiting studies that include Comparator, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Comparator trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Comparator an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Comparator or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.