Treatment
Comparator clinical trials
We’re tracking 1,730 recruiting studies that include Comparator, each written for real people, not researchers, below.
Recruiting studies
- NCT04621279Recruiting
Cooling treatment study for babies with mild brain injury
This study compares different approaches to “cooling” treatment in newborns with mild hypoxic-ischemic encephalopathy (mild brain injury from not enough oxygen around birth). The goal is to see which approach works best and is safest for babies like yours.
Dallas, TexasAges 8 months+ - NCT04629144RecruitingPhase 2
Belimumab for active cryoglobulinemia vasculitis after rituximab
This Phase 2 study tests belimumab (or a placebo) to see if it improves safety and disease control in adults with active cryoglobulinemia vasculitis. You may be eligible if you have had rituximab induction treatment shortly before joining, and your illness is still active.
BloisAges 18 years+ - NCT04656184RecruitingPhase 3
Anakinra vs IVIG for kids who don’t respond to first IVIG
This study compares two treatments—anakinra and IVIG—for children with Kawasaki disease who still have fever after their first standard IVIG treatment. It aims to find which option works better and is safer for “IVIG non-responders” who may be at risk for heart complications.
Le Kremlin-Bicêtre, Val De MarneAges 3 months–17 years - NCT04669873Recruiting
Partial breast radiation vs whole breast radiation after lumpectomy
This trial studies whether treating only part of the breast with radiation works as well as treating the whole breast in people with early breast cancer after lumpectomy. It may help reduce radiation exposure to healthy tissue, while still controlling the cancer.
São Paulo, São PauloAges 50–90 - NCT04671667RecruitingPhase 2
Pembrolizumab vs chemo-radiation after surgery for recurrent head/neck cancer
This trial tests whether pembrolizumab (an immunotherapy drug) works better than the usual chemo plus radiation after surgery for cancer that has come back in the head and neck area. It may help reduce cancer returning or spreading by using your immune system, but eligibility depends on how the cancer came back and your prior treatments.
Birmingham, AlabamaAges 18–79 - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04702256RecruitingPhase 3
Treating lupus kidney inflammation with or without extra steroid tablets
This trial tests whether adding standard oral steroid tablets to mycophenolate helps lupus nephritis (inflammation of the kidneys) more than using obinutuzumab plus mycophenolate, without extra oral steroids. It may help find a treatment plan that controls active kidney disease while changing how much steroid is used.
ParisAges 14 years+ - NCT04707976Recruiting
Smart anal irrigation vs standard care for bowel issues in MS
This study compares a smart device for transanal irrigation with regular bowel care in people with multiple sclerosis (MS) who have ongoing bowel problems. It aims to see if the smart irrigation approach improves bowel control and reduces symptoms.
AarhusAges 18 years+ - NCT04794777RecruitingPhase 3
Tests targeted scans and rescue radiation for returning prostate cancer
This trial studies whether a targeted scan (PSMA PET/CT) can help doctors choose the best “salvage” radiation treatment when prostate cancer comes back by PSA blood tests after surgery. It may help some people avoid under- or over-treating the areas where the cancer is returning.
Gothenburg, GöteborgAges 18 years+ - NCT04795843Recruiting
Exercise and education versus usual care for hip dysplasia
This trial compares a structured exercise and patient education program with standard care in people with hip dysplasia. It may help improve hip and groin pain and function, especially if you are not getting the usual surgery (periacetabular osteotomy, or PAO).
Aarhus NAges 18–50 - NCT04809025Recruiting
Testing biopsy samples vs surgery samples for stomach cancer testing
This study compares two ways of getting stomach cancer tissue: a camera-guided biopsy and a tissue sample taken during planned stomach surgery. The goal is to see which sample better supports molecular (gene-based) testing to guide diagnosis.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04812132Recruiting
Compare two types of weight-loss stomach surgery
This study compares two surgical methods used for weight loss: OAGB and a longer-limb Roux gastric bypass. It may help find which option works best for people with severe obesity and obesity-related health problems.
TartuAges 18–60 - NCT04816292Recruiting
Compare removal of colon polyps with hot vs cold snare
This study compares two ways doctors remove certain colon polyps during colonoscopy: “hot snare” versus “cold snare.” It’s looking at whether one method removes polyps better and with fewer problems for people with polyps that are 10–15 mm.
München, BavariaAges 18–80 - NCT04823299Recruiting
Atrial fibrillation ablation using two different energy types
This trial tests whether one ablation approach works better than another for paroxysmal (intermittent) atrial fibrillation by targeting the heart’s “triggers” and “substrate” (where the rhythm problem is). If you qualify, you’ll be randomly assigned to one of two ablation energy methods during a pulmonary vein isolation procedure.
Ottawa, OntarioAges 18 years+ - NCT04843215Recruiting
Surgery comparison for advanced stomach cancer after initial surgery
This trial studies whether removing all of the fatty lining (omentum) or only part of it during surgery leads to better outcomes in people with advanced stomach cancer. It also checks that participants can safely have the same stomach-cancer chemotherapy plan after surgery.
Tianjin, Tianjin MunicipalityAges 18–70 - NCT04846959Recruiting
Pregnancy outcomes study for people exposed to risankizumab
This study looks at pregnancy outcomes in people who took risankizumab during pregnancy (or shortly before getting pregnant). It compares them with pregnancies exposed to similar biologic medicines, to better understand risks and what to expect.
Morrisville, North CarolinaAges Any age - NCT04852198Recruiting
Compare two weight-loss surgeries in people with high BMI
This study compares two types of bariatric surgery to see which one works as well as the other for weight loss and health. You may be a candidate if you have a high BMI and specific related health problems, and if certain stomach and digestive issues don’t apply to you.
Almere StadAges 18–65 - NCT04855773Recruiting
Mobile text-message support to help people stay on PrEP
This trial tests whether phone-based (iPhone/Android) text-message support can improve how consistently people use PrEP, an HIV prevention medicine. It may help you stay on track with refills and clinic visits, especially if you’re at higher risk of stopping PrEP.
San Francisco, CaliforniaAges 15 years+ - NCT04868578Recruiting
Vitamin PPI supplements for ectopic calcification in PXE
This trial studies whether taking PPI-type supplements can slow or reduce unwanted calcification in people with PXE. It’s meant to help manage disease changes caused by abnormal calcium deposits, based on your medical testing.
AngersAges 18–65 - NCT04893863RecruitingPhase 1/Phase 2
Plurogel vs standard dressing for partial-thickness burn wounds
This trial compares Plurogel® to the usual topical dressing for people with partial-thickness burns on both limbs. It aims to see whether the new gel dressing improves healing for these burn injuries.
Winnipeg, ManitobaAges 18 years+ - NCT04897516RecruitingPhase 3
Test whether shorter benznidazole courses work for Chagas
This trial compares a shorter course of benznidazole (a medicine for Chagas disease) to the standard longer treatment. It aims to see if the shorter regimen works as well and is safe for people with confirmed Chagas infection.
Buenos AiresAges 18–60 - NCT04902703RecruitingPhase 2
GM-CSF drug trial for mild to moderate Alzheimer’s disease
This Phase 2 study tests whether sargramostim (a GM-CSF related medicine) is safe and can slow or improve Alzheimer’s symptoms. You might be a good fit if you have mild or moderate Alzheimer’s, positive amyloid testing, and can complete frequent visits with a close caregiver who knows you well.
Aurora, ColoradoAges 60–85 - NCT04923191Recruiting
Test heart-procedure guidance from scans versus usual care
This study compares two ways of guiding a heart stent procedure: using information from a special angiography scan versus using standard practice. It may help your care team choose the best treatment to improve heart outcomes after stenting.
AalstAges 18 years+ - NCT04925154Recruiting
Study of decision-making for rectal cancer treatment
This study asks people newly diagnosed with rectal cancer about how they choose between treatment benefits and quality of life. It uses questionnaires to understand what tradeoffs matter to patients so care discussions can be improved.
Montreal, QuebecAges 18 years+
Common questions
- Are there clinical trials studying Comparator?
- Yes. Clin2 currently lists 1,730 recruiting studies that include Comparator, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Comparator trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Comparator an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Comparator or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.