Clin2
NCT03984591Possibly a fitEnrolling by invitation

Compare spironolactone vs eplerenone for heart failure patients

Systolic Heart Failure

Treatments studied

Part of Heart & circulation clinical trials.

This study uses Denmark’s heart failure registry to compare two common tablet medicines—spironolactone and eplerenone—for people with symptomatic systolic heart failure. It aims to see which one leads to better health outcomes over time.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
7,200 people
Ages
Any age
Study type
Interventional

Who can take part

  • You are listed in the Danish Heart Failure Registry
  • Your heart function test shows left ventricular ejection fraction under 40%
  • You recently filled a prescription for an “aldosterone antagonist” (either spironolactone or eplerenone)
  • You had not filled an aldosterone antagonist prescription before being registered in the registry

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04996550Not yet recruiting
Comparing Two Heart Medicines for Heart Failure

This study compares two heart medicines, carvedilol and metoprolol succinate, for people with a certain type of heart failure. It aims to see if they work just as well as each other.

Odense, Region Syddanmark
NCT02901184Recruiting· Phase 3
Spironolactone start study for heart failure with preserved pumping

This trial tests whether starting spironolactone helps people with heart failure symptoms when the heart pumps “preserved” (not severely reduced). Participants are assigned to start spironolactone or usual care so researchers can see if it improves outcomes.

Alexander City, Alabama
NCT07523867Not yet recruiting· Phase 4
Comparing two potassium-lowering heart failure drugs

This study compares two medicines, spironolactone and finerenone, to see which one manages potassium levels better in people with heart failure, type 2 diabetes, and kidney disease. Participants have high potassium levels, and the trial aims to find a safer way to manage this.

NCT07688928Recruiting
Finerenone vs spironolactone for high blood pressure from aldosteronism

This trial compares two medicines, finerenone and spironolactone, to see which works better and is safer for lowering blood pressure in people with primary aldosteronism. It may help you if you have high blood pressure caused by too much aldosterone.

Dhaka
NCT05198791Recruiting· Phase 2
Eplerenone for heart injury without blocked heart arteries

This Phase 2 study tests whether eplerenone can improve outcomes after a heart attack (or similar heart injury) when coronary angiography shows no blocked heart arteries. It focuses on people with added cardiovascular risk factors and evaluates how well the treatment works for heart recovery and strain on the heart.

East Kilbride, Lanarkshire
NCT05030545Recruiting· Phase 4
PET/CT study of spironolactone or eplerenone in primary aldosteronism

This study looks at how primary aldosteronism affects the heart and blood vessels, and whether blocking its hormone signal (with spironolactone or eplerenone) changes those findings on imaging tests. It is small and focuses on people with confirmed or suspected primary aldosteronism who are being followed for heart health.

Boston, Massachusetts

Hear when a new Systolic Heart Failure trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.