Surgery-like brain radiation vs avoiding the memory center
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This trial compares two ways of giving radiation to the brain for people with 5 or more brain metastases: focused stereotactic radiosurgery, or a whole-brain approach that tries to spare the memory area (with memantine). It aims to see which method better protects thinking and memory while still treating the tumors.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have 5 to 15 brain metastases found on a recent MRI (within 30 days).
- Your largest brain tumor is smaller than 2.5 cm.
- You’re 18 or older and have a non-blood cancer (not leukemia/lymphoma).
- You can have brain MRI scans and take part in quality-of-life questionnaires in English or French.
- You have not had radiation to your brain before, and you can start the study treatment within 14 days of joining.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 2 study tests a treatment plan that combines whole-brain radiation therapy with an additional approach to help people with brain metastases. It aims to improve outcomes while also tracking brain function and memory over time.
This trial tests a new approach for people with a single large brain tumor that has spread from another cancer. You would receive a short, focused dose of radiation (stereotactic radiosurgery) in small, separate treatments, followed by surgery to remove the tumor. The goal is to see if this combination works better than the usual treatment.
This Phase 2 trial tests a modified form of whole brain radiation to see if it can better protect thinking and memory in adults with brain metastases. You may join even if you’ve had other cancer treatments before, as long as your situation fits the study rules.
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