Treatment
Estradiol clinical trials
We’re tracking 42 recruiting studies that include Estradiol, each written for real people, not researchers, below.
Recruiting studies
- NCT07160504RecruitingPhase 4
Vaginal estrogen's effect on blood clotting in postmenopausal women
This trial tests if low-dose vaginal estrogen tablets affect blood clotting in postmenopausal women with vaginal atrophy. It includes women both with and without a past blood clot to see if the treatment is safe.
Aarhus NAges 50 years+ - NCT06969326RecruitingPhase 3
Estrogen cream after hysterectomy for transgender men
This study tests whether using a topical estrogen cream after hysterectomy surgery can help transgender men have a better recovery. Participants will be randomly assigned to use the cream or not, and researchers will follow up by text message.
Providence, Rhode IslandAges 18 years+ - NCT07100782RecruitingPhase 3
Estrogen & pain trial for endometriosis pelvic pain
This study tests whether a drug called relugolix CT can reduce pelvic pain from endometriosis. You'll have brain scans and pain tests to measure how your body processes pain. It might help if other treatments haven't worked well.
Ann Arbor, MichiganAges 18–49 - NCT07083635RecruitingPhase 2
Hormonal patch for irregular bleeding with contraceptive implant
This trial tests a skin patch containing two hormones (estrogen and progestin) to see if it can stop irregular bleeding in women who have a contraceptive implant. If you're having unpredictable or prolonged bleeding with your implant, this treatment may help regulate your periods.
Pathum Wan, BangkokAges 18 years+ - NCT07061093Recruiting
Hormonal birth control and 24-hour blood pressure study
This study looks at how different types of hormonal birth control might affect your blood pressure over 24 hours. It could help you and your doctor choose a birth control that is safer for your heart.
Genova, GEAges 18–50 - NCT04596592Recruiting
Puberty blockers and estradiol effects on heart health
This study looks at how puberty blockers and then estradiol (estrogen) may affect heart and metabolism health in teens. It may help doctors understand risks and benefits for transgender youth starting gender-affirming hormone care.
Aurora, ColoradoAges 13–16 - NCT06953076Recruiting
Ultrasound changes in fibroids during Relugolix treatment
This study tests whether an ultrasound can show how fibroids (benign uterine growths) change during treatment with a medication called Relugolix (combined with estrogen and progestin). It's for women who have heavy bleeding and want to know if the medication can shrink their fibroids.
RomaAges 18 years+ - NCT06798571RecruitingPhase 4
How menopause affects body temperature control
This study looks at how menopause changes the way your body handles heat. It may help women understand temperature changes during menopause.
University Park, PennsylvaniaAges 42–64 - NCT06247267Recruiting
Hormone replacement therapy in military members
This study is looking at how sex hormone replacement therapy affects active-duty military members and their families. It aims to understand the effects in people with low testosterone or those receiving gender-affirming hormones.
Bethesda, MarylandAges 18–65 - NCT06686537RecruitingPhase 2
Study on metabolism and hormones in women
This study looks at how metabolism and hormones are connected in women. It tests a treatment to see if it can improve metabolic health related to the menstrual cycle.
Aurora, ColoradoAges 18–38 - NCT06610305RecruitingPhase 4
Hormones, mood, and reward in women with PMS-related depression
This study looks at how changes in hormone levels during the menstrual cycle affect mood and the brain's reward system in women with depression that gets worse before their period. The goal is to understand why this happens so better treatments can be developed.
Chapel Hill, North CarolinaAges 18–45 - NCT06439524RecruitingPhase 3
Medication after endometriosis surgery study
This trial tests whether taking a medication (Rel-CT) after surgery helps improve outcomes for people with endometriosis. It may reduce the chance of symptoms returning after the tissue is removed.
Wynnewood, PennsylvaniaAges 18 years+ - NCT06343870RecruitingPhase 3
Hormone implants for menopause after cervical cancer or early menopause
This trial tests hormone implants (estradiol and testosterone) to treat menopause symptoms in women who have had their ovaries and uterus removed due to cervical cancer, or who have early menopause. The implants are placed under the skin and may help with hot flashes, mood, and sexual health.
São Paulo, São PauloAges 18–60 - NCT06334315RecruitingPhase 4
Birth control pill study for healthy women
This study looks at how genes affect the way the body processes birth control pills. You take a low-dose pill for one cycle and have blood draws to measure hormone levels.
Aurora, ColoradoAges 18–45 - NCT06179303RecruitingPhase 2
Imaging to predict response to abemaciclib for advanced breast cancer
This trial tests if a special PET scan can predict how well the drug abemaciclib works for people with advanced hormone receptor-positive, HER2-negative breast cancer. If you qualify, you would receive abemaciclib and have imaging scans to see if your cancer responds.
St Louis, MissouriAges 18 years+ - NCT05473273Recruiting
Blood test study during normal frozen embryo transfer
This study measures changes in your blood immune markers during frozen embryo transfer when the embryo is chromosomally normal. It may help clinics understand what blood immune patterns relate to successful pregnancy in natural or hormone-prepared cycles.
Abu Dhabi, Abu Dhabi EmirateAges 18–40 - NCT05457972RecruitingPhase 4
Using vaginal estrogen to support breastfeeding after delivery
This study tests whether using estrogen placed in the vagina after childbirth can help breastfeeding or milk pumping go more smoothly. It’s aimed at people who are at least 6 weeks postpartum and plan to breastfeed or pump.
Cleveland, OhioAges 18–50 - NCT04783857RecruitingPhase 4
Hormone therapy to prevent smoking relapse after childbirth
This trial tests whether giving progesterone after childbirth can help new mothers stay quit from smoking, reducing secondhand smoke exposure to their babies. It's for women who smoked before pregnancy and want to remain smoke-free after delivery.
Minneapolis, MinnesotaAges 18–45
Common questions
- Are there clinical trials studying Estradiol?
- Yes. Clin2 currently lists 42 recruiting studies that include Estradiol, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Estradiol trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Estradiol an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Estradiol or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.