Treatment
Estradiol clinical trials
We’re tracking 42 recruiting studies that include Estradiol, each written for real people, not researchers, below.
Recruiting studies
- NCT07831499RecruitingPhase 4
Comparing two hormone therapy schedules for brain health in menopause
This study compares two ways of taking estrogen during menopause to see which one better supports memory and thinking. You would receive either a steady dose or a pulse dose of estrogen, along with a progestin, and researchers will track your brain health over time.
Aurora, ColoradoAges 38–60 - NCT07620587Recruiting
How hormones affect appetite and energy in healthy young adults
This study examines how estradiol and progesterone (two female hormones) influence hunger, appetite, and how your body uses energy. Understanding this connection may help explain why appetite and energy levels change throughout the menstrual cycle.
Waterloo, OntarioAges 18–30 - NCT07574216Recruiting
DHEA vs Estradiol for Vaginal Symptoms After Menopause
This study compares two vaginal treatments—DHEA and estradiol—to help relieve common menopause symptoms like dryness, itching, or discomfort during sex. You'll use vaginal therapy (applied directly where symptoms occur) and help researchers understand which works better.
Phoenix, ArizonaAges 40–90 - NCT07568574Enrolling by invitation
Medical Study of Performance-Enhancing Substances in Elite Athletes
This study looks at how medically supervised performance-enhancing substances affect elite athletes' health and quality of life. Participants must be retired from professional sports and willing to undergo careful medical monitoring throughout the trial.
Abu DhabiAges 18 years+ - NCT07419594Recruiting
Estradiol and Intrusive Memories Study
This study tests whether a single dose of estradiol (a hormone) can reduce intrusive memories in healthy women. It aims to see if this hormone can help prevent distressing memories from forming after a stressful event.
Berlin, State of BerlinAges 18–45 - NCT06856174RecruitingPhase 4
Menopause Hormone Therapy for Women with HIV
This trial tests whether hormone therapy can help manage hot flashes and night sweats in women living with HIV who are going through menopause. It's designed to see if this treatment is safe and effective for this group.
Birmingham, AlabamaAges 40–60 - NCT03401047RecruitingEarly Phase 1
Estradiol patch study for hormone signaling in PCOS
This early-stage study tests whether adding an estrogen skin patch (estradiol) can change how your body releases key reproductive hormones in adults with PCOS. It may help researchers better understand PCOS-related hormone control and signaling.
Charlottesville, VirginiaAges 18–30 - NCT05900895RecruitingPhase 1
Estradiol plus olaparib for ER-positive breast cancer
This early-stage study tests whether combining estradiol (a form of estrogen) with olaparib (a targeted cancer medicine) can control ER-positive, HER2-negative breast cancer that has spread or come back. It may help by attacking cancer cells in a new way after standard hormone-based treatments.
Lebanon, New HampshireAges 18 years+ - NCT05716516RecruitingPhase 2
Estradiol pill for ER-positive advanced breast cancer
This trial studies whether an estradiol (a form of estrogen) treatment can help people with ER-positive advanced breast cancer. It is mainly for post-menopausal women whose cancer is not curable and has already been treated with endocrine (hormone) therapies.
Lebanon, New HampshireAges 18 years+ - NCT05282277RecruitingPhase 4
Estradiol to improve brain and reward changes in midlife women
This study tests whether a hormone called estradiol (given as a patch and pill) changes how the brain and body respond to reward in some midlife women with low pleasure and/or psychosis symptoms during menopause transition. It may help researchers understand whether estrogen treatment can improve mood-related “reward” function in this group.
Chapel Hill, North CarolinaAges 45–55 - NCT04685148RecruitingPhase 1/Phase 2
Study of mental health treatment during pregnancy
This trial studies a treatment aimed at improving maternal mental health during pregnancy. It focuses on people who have had depression around pregnancy before, and checks whether the approach is safe and helpful for them.
CopenhagenAges 18–45 - NCT04043520RecruitingPhase 4
Menopause, aging, and energy study
This study looks at how menopause and aging affect the body's energy use. It tests a hormone medication to see how it changes energy levels in healthy women who are recently past menopause.
Aurora, ColoradoAges 40–65 - NCT05280028Recruiting
Hormone treatment for overactive bladder and mood symptoms
This trial studies whether hormone treatment can improve overactive bladder symptoms, sexual well-being, mood (depressive symptoms), and body “autonomic” function (automatic body functions like heart rate and sweating) in post-menopausal women. It may help by targeting menopausal changes that can affect these symptoms.
Banqiao District, New TaipeiAges 20 years+ - NCT06264882RecruitingPhase 4
Study on ovarian suppression and body changes
This study looks at how temporarily stopping ovarian function affects weight, body fat, and blood vessel health in premenopausal women. If you qualify, you might help researchers understand the risks and benefits of short-term estrogen suppression.
Aurora, ColoradoAges 20–45 - NCT05221021RecruitingPhase 4
Vaginal estrogen vs oral bladder medicine for overactive bladder
This study compares vaginal estradiol (a hormone placed in the vagina) versus an oral beta-3 medicine called mirabegron for overactive bladder symptoms. It looks to see which treatment works better and is safer for postmenopausal women.
Bethesda, MarylandAges 18 years+ - NCT06544473RecruitingPhase 4
Estrogen pill vs. patch for Turner syndrome
This trial compares oral and transdermal (patch) estrogen to find the right dose for women with Turner syndrome. It aims to see which method works best for hormone replacement.
Aarhus, Aarhus NAges 18–50 - NCT06570460RecruitingPhase 4
Estrogen pills vs. patch for Turner syndrome
This study compares two ways of taking estrogen (pills or a skin patch) in women with Turner syndrome to see which works better over time. It also includes healthy women for comparison.
Aarhus, Aarhus NAges 18–50 - NCT05058872RecruitingPhase 4
Study links birth-control hormones to brain reward responses
This Phase 4 study uses brain imaging and daily questions to understand how contraceptive hormones may affect reward and brain signals. You may be able to join if you meet the health, birth-control, and safety requirements for MRI.
Aurora, ColoradoAges 18 years+ - NCT07568509RecruitingEarly Phase 1
Oxytocin levels in children with pituitary disease
This study measures oxytocin (a natural hormone) levels in children who have pituitary gland problems. Researchers want to understand if children with certain pituitary conditions don't make enough oxytocin, which could help guide future treatments.
Boston, MassachusettsAges 7–21 - NCT07499804RecruitingPhase 4
Tadalafil for thicker uterine lining before embryo transfer
This study tests whether tadalafil (a medication often used for erectile dysfunction) can help thicken the lining of the uterus before transferring a frozen embryo. If you have good quality frozen embryos, this may improve your chance of a successful pregnancy.
Banī Suwayf, Beni Suweif GovernorateAges 18–43 - NCT07361263Recruiting
Study of oxytocin response to oral estrogens
This trial looks at how the body's oxytocin level changes after taking estrogen pills. It includes healthy people and those with a condition called AVP-deficiency (a lack of a hormone that controls water balance). The study aims to understand how estrogen affects oxytocin.
BaselAges 18–50 - NCT07340190RecruitingPhase 1
How pelabresib affects other drugs in advanced cancer
This study tests how a new drug (pelabresib) interacts with other medicines like diabetes pills, a sedative, and birth control pills. It is for people with advanced cancer to help understand safe dosing.
BordeauxAges 18 years+ - NCT07254429RecruitingPhase 2
The Copenhagen Menopause Study for hot flash relief
This study tests a new treatment for women going through menopause who have frequent hot flashes. It aims to find a safe and effective way to reduce moderate to severe hot flashes.
HerlevAges 40–65 - NCT06896617RecruitingPhase 4
Corpus Luteum's effect on frozen embryo transfer pregnancies
This study looks at whether having a corpus luteum (the structure left after an egg is released) affects pregnancy outcomes in frozen embryo transfer cycles. It aims to help doctors choose the best way to prepare the body for embryo transfer.
Barcelona, SpainAges 18–41
What Estradiol is being studied for
Conditions with recruiting Estradiol studies.
Common questions
- Are there clinical trials studying Estradiol?
- Yes. Clin2 currently lists 42 recruiting studies that include Estradiol, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Estradiol trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Estradiol an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Estradiol or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.