Treatment
Estradiol clinical trials
We’re tracking 43 recruiting studies that include Estradiol, each written for real people, not researchers, below.
Recruiting studies
- NCT07620587Recruiting
How hormones affect appetite and energy in healthy young adults
This study examines how estradiol and progesterone (two female hormones) influence hunger, appetite, and how your body uses energy. Understanding this connection may help explain why appetite and energy levels change throughout the menstrual cycle.
Waterloo, OntarioAges 18–30 - NCT03401047RecruitingEarly Phase 1
Estradiol patch study for hormone signaling in PCOS
This early-stage study tests whether adding an estrogen skin patch (estradiol) can change how your body releases key reproductive hormones in adults with PCOS. It may help researchers better understand PCOS-related hormone control and signaling.
Charlottesville, VirginiaAges 18–30 - NCT05282277RecruitingPhase 4
Estradiol to improve brain and reward changes in midlife women
This study tests whether a hormone called estradiol (given as a patch and pill) changes how the brain and body respond to reward in some midlife women with low pleasure and/or psychosis symptoms during menopause transition. It may help researchers understand whether estrogen treatment can improve mood-related “reward” function in this group.
Chapel Hill, North CarolinaAges 45–55 - NCT05716516RecruitingPhase 2
Estradiol pill for ER-positive advanced breast cancer
This trial studies whether an estradiol (a form of estrogen) treatment can help people with ER-positive advanced breast cancer. It is mainly for post-menopausal women whose cancer is not curable and has already been treated with endocrine (hormone) therapies.
Lebanon, New HampshireAges 18 years+ - NCT05900895RecruitingPhase 1
Estradiol plus olaparib for ER-positive breast cancer
This early-stage study tests whether combining estradiol (a form of estrogen) with olaparib (a targeted cancer medicine) can control ER-positive, HER2-negative breast cancer that has spread or come back. It may help by attacking cancer cells in a new way after standard hormone-based treatments.
Lebanon, New HampshireAges 18 years+ - NCT06856174RecruitingPhase 4
Menopause Hormone Therapy for Women with HIV
This trial tests whether hormone therapy can help manage hot flashes and night sweats in women living with HIV who are going through menopause. It's designed to see if this treatment is safe and effective for this group.
Birmingham, AlabamaAges 40–60 - NCT07419594Recruiting
Estradiol and Intrusive Memories Study
This study tests whether a single dose of estradiol (a hormone) can reduce intrusive memories in healthy women. It aims to see if this hormone can help prevent distressing memories from forming after a stressful event.
Berlin, State of BerlinAges 18–45 - NCT07568574Enrolling by invitation
Medical Study of Performance-Enhancing Substances in Elite Athletes
This study looks at how medically supervised performance-enhancing substances affect elite athletes' health and quality of life. Participants must be retired from professional sports and willing to undergo careful medical monitoring throughout the trial.
Abu DhabiAges 18 years+ - NCT07340190RecruitingPhase 1
How pelabresib affects other drugs in advanced cancer
This study tests how a new drug (pelabresib) interacts with other medicines like diabetes pills, a sedative, and birth control pills. It is for people with advanced cancer to help understand safe dosing.
BordeauxAges 18 years+ - NCT05280028Recruiting
Hormone treatment for overactive bladder and mood symptoms
This trial studies whether hormone treatment can improve overactive bladder symptoms, sexual well-being, mood (depressive symptoms), and body “autonomic” function (automatic body functions like heart rate and sweating) in post-menopausal women. It may help by targeting menopausal changes that can affect these symptoms.
Banqiao District, New TaipeiAges 20 years+ - NCT05058872RecruitingPhase 4
Study links birth-control hormones to brain reward responses
This Phase 4 study uses brain imaging and daily questions to understand how contraceptive hormones may affect reward and brain signals. You may be able to join if you meet the health, birth-control, and safety requirements for MRI.
Aurora, ColoradoAges 18 years+ - NCT05221021RecruitingPhase 4
Vaginal estrogen vs oral bladder medicine for overactive bladder
This study compares vaginal estradiol (a hormone placed in the vagina) versus an oral beta-3 medicine called mirabegron for overactive bladder symptoms. It looks to see which treatment works better and is safer for postmenopausal women.
Bethesda, MarylandAges 18 years+ - NCT06343870RecruitingPhase 3
Hormone implants for menopause after cervical cancer or early menopause
This trial tests hormone implants (estradiol and testosterone) to treat menopause symptoms in women who have had their ovaries and uterus removed due to cervical cancer, or who have early menopause. The implants are placed under the skin and may help with hot flashes, mood, and sexual health.
São Paulo, São PauloAges 18–60 - NCT07160504RecruitingPhase 4
Vaginal estrogen's effect on blood clotting in postmenopausal women
This trial tests if low-dose vaginal estrogen tablets affect blood clotting in postmenopausal women with vaginal atrophy. It includes women both with and without a past blood clot to see if the treatment is safe.
Aarhus NAges 50 years+ - NCT04783857RecruitingPhase 4
Hormone therapy to prevent smoking relapse after childbirth
This trial tests whether giving progesterone after childbirth can help new mothers stay quit from smoking, reducing secondhand smoke exposure to their babies. It's for women who smoked before pregnancy and want to remain smoke-free after delivery.
Minneapolis, MinnesotaAges 18–45 - NCT06179303RecruitingPhase 2
Imaging to predict response to abemaciclib for advanced breast cancer
This trial tests if a special PET scan can predict how well the drug abemaciclib works for people with advanced hormone receptor-positive, HER2-negative breast cancer. If you qualify, you would receive abemaciclib and have imaging scans to see if your cancer responds.
St Louis, MissouriAges 18 years+ - NCT06334315RecruitingPhase 4
Birth control pill study for healthy women
This study looks at how genes affect the way the body processes birth control pills. You take a low-dose pill for one cycle and have blood draws to measure hormone levels.
Aurora, ColoradoAges 18–45 - NCT06896617RecruitingPhase 4
Corpus Luteum's effect on frozen embryo transfer pregnancies
This study looks at whether having a corpus luteum (the structure left after an egg is released) affects pregnancy outcomes in frozen embryo transfer cycles. It aims to help doctors choose the best way to prepare the body for embryo transfer.
Barcelona, SpainAges 18–41 - NCT05457972RecruitingPhase 4
Using vaginal estrogen to support breastfeeding after delivery
This study tests whether using estrogen placed in the vagina after childbirth can help breastfeeding or milk pumping go more smoothly. It’s aimed at people who are at least 6 weeks postpartum and plan to breastfeed or pump.
Cleveland, OhioAges 18–50 - NCT07568509RecruitingEarly Phase 1
Oxytocin levels in children with pituitary disease
This study measures oxytocin (a natural hormone) levels in children who have pituitary gland problems. Researchers want to understand if children with certain pituitary conditions don't make enough oxytocin, which could help guide future treatments.
Boston, MassachusettsAges 7–21 - NCT06686537RecruitingPhase 2
Study on metabolism and hormones in women
This study looks at how metabolism and hormones are connected in women. It tests a treatment to see if it can improve metabolic health related to the menstrual cycle.
Aurora, ColoradoAges 18–38 - NCT03557619RecruitingPhase 1
Venetoclax test in women with specific non-Hodgkin lymphomas
This Phase 1 study tests how venetoclax affects certain hormone pills (ethinyl estradiol and levonorgestrel) in women with different non-Hodgkin lymphomas. It’s mainly looking at safety and drug interactions, which could help guide treatment for people who need hormone-based contraception.
Detroit, MichiganAges 18 years+ - NCT04596592Recruiting
Puberty blockers and estradiol effects on heart health
This study looks at how puberty blockers and then estradiol (estrogen) may affect heart and metabolism health in teens. It may help doctors understand risks and benefits for transgender youth starting gender-affirming hormone care.
Aurora, ColoradoAges 13–16 - NCT04685148RecruitingPhase 1/Phase 2
Study of mental health treatment during pregnancy
This trial studies a treatment aimed at improving maternal mental health during pregnancy. It focuses on people who have had depression around pregnancy before, and checks whether the approach is safe and helpful for them.
CopenhagenAges 18–45
What Estradiol is being studied for
Conditions with recruiting Estradiol studies.
Common questions
- Are there clinical trials studying Estradiol?
- Yes. Clin2 currently lists 43 recruiting studies that include Estradiol, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Estradiol trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Estradiol an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Estradiol or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.