Treatment
Menopausal Hormone Therapy clinical trials
We’re tracking 35 recruiting studies that include Menopausal Hormone Therapy, each written for real people, not researchers, below.
Recruiting studies
- NCT05586724RecruitingPhase 3
Progesterone vs another hormone added to estrogen for menopause symptoms
This Phase 3 study compares two types of progesterone—micronized progesterone versus norethisterone acetate—both used with estrogen to treat menopause symptoms that affect daily life. It aims to see which combination works better and is tolerated over time for women with an intact uterus.
StockholmAges 45–60 - NCT07848438Recruiting
Sex hormones and aging study
This study looks at how sex hormones affect the body as we age. Participants may help researchers understand changes in muscles, bones, or other functions, which could lead to better treatments for aging-related conditions.
Ann Arbor, MichiganAges 50–70 - NCT07810959Recruiting
Hormone therapy effects on breast and blood vessels in menopause
This study looks at how menopausal hormone therapy (medicines that replace hormones your body no longer makes) affects your breasts and blood vessels. If you join, you'll be followed for a year to see how the treatment works for your symptoms and how it impacts your health.
BursaAges 45–60 - NCT06530459RecruitingPhase 2/Phase 3
The MUSE Study for Menopausal Joint Pain
This study tests whether a treatment can help women with joint pain and stiffness that started or worsened during menopause. It focuses on women who are within 5 years of menopause and have pain in multiple joints.
SingaporeAges 30–59 - NCT06704516RecruitingPhase 1
HRT and fatty liver disease in menopausal women – a pilot study
This study tests whether starting hormone replacement therapy (HRT) improves liver health in women with menopause and fatty liver disease (MASLD). It aims to understand how HRT might help reduce fat in the liver.
Oxford, OxfordshireAges 18 years+ - NCT07242391Recruiting
Menopausal hormone therapy and heart function study
This study looks at how menopausal hormone therapy might affect the heart's pumping ability. It may help women who are naturally entering menopause understand if hormone therapy can protect their heart health.
Rochester, MinnesotaAges 45–60 - NCT07500922Recruiting
Menopause effects on brain activity study
This study looks at how menopause affects brain signals controlling movement. It offers combined hormone treatment to eligible women.
JyväskyläAges 50–59 - NCT05831709Recruiting
Hormone therapy and supervised exercise in menopausal women
This study looks at how hormone replacement therapy and a supervised exercise program may change body composition, heart health risk, and insulin sensitivity in postmenopausal women. It may help participants understand which combination works best for metabolic and cardiovascular health after menopause.
GhentAges 45–65 - NCT07292857Recruiting
Respiratory infection risk in postmenopausal women on HRT or not
This study looks at how the risk of respiratory infections (like colds or flu) may differ in postmenopausal women who use hormone replacement therapy (HRT) and those who do not. You will wear a smartwatch for six months and track your health through a smartphone app.
BernAges 40–60 - NCT06497894RecruitingPhase 4
Hormone therapy for sleep in late menopause
This trial tests whether hormone replacement therapy (HRT) can improve sleep for women in late menopause who have insomnia. If you are in late menopause and struggle with poor sleep, this study may offer a treatment option.
BernAges 45–69 - NCT07391774RecruitingPhase 3
Hormone therapy with or without chemo for early breast cancer
This trial tests whether skipping chemotherapy and using only hormone therapy with a drug called ribociclib works as well as chemotherapy followed by hormone therapy with ribociclib for certain early breast cancers that have a low risk of coming back.
Jonesboro, ArkansasAges 18 years+ - NCT07406412Recruiting
Hormones and heart health before and after ovary removal
This study looks at how hormones affect heart health and metabolism in women who are having their ovaries removed (for non-cancer reasons). It will help researchers understand the changes that happen after surgery and how to better manage health during this transition.
HelsinkiAges 35–50 - NCT07742488Recruiting
Statins and hormone therapy for cholesterol in menopause
This study looks at whether taking statins (cholesterol-lowering medicine) along with hormone replacement therapy (HRT) affects blood clotting in women going through menopause who have high cholesterol. It may help doctors understand how these medicines work together.
Pisa, ItalyAges 45–55 - NCT06570460RecruitingPhase 4
Estrogen pills vs. patch for Turner syndrome
This study compares two ways of taking estrogen (pills or a skin patch) in women with Turner syndrome to see which works better over time. It also includes healthy women for comparison.
Aarhus, Aarhus NAges 18–50 - NCT06855784Recruiting
Time-Restricted Eating for Menopause and Breast Cancer
This study tests if time-restricted eating (eating only during a set window each day) can help women with menopausal symptoms, including those who have had hormone-sensitive breast cancer and are on hormone-blocking therapy.
Geneva, Canton of GenevaAges 45–60 - NCT07511660Enrolling by invitation
Ovarian cell injection for perimenopause symptom relief
This trial tests injecting special cells called Muse cells into the ovaries to help relieve perimenopause symptoms and possibly restore ovarian function. It may help women experiencing irregular periods, hot flashes, sleep problems, mood changes, or trouble thinking clearly.
Monterrey, Nuevo LeónAges 28–70 - NCT06873971Recruiting
Laser plus vaginal estrogen for menopause symptoms
This trial tests if combining a special laser treatment with a vaginal estrogen cream can help relieve menopause symptoms like vaginal dryness, burning, and pain during sex. It may be a good option for women who have not used hormone therapy recently.
São Paulo, São PauloAges 45–70 - NCT06975111RecruitingPhase 2/Phase 3
Improving health during menopause
This trial studies ways to help women during the late menopausal transition. It uses a smartphone app and telehealth visits to track your health and help you feel better.
Aurora, ColoradoAges 45–55 - NCT07865377Recruiting
Resveratrol supplement for heart disease in postmenopausal women
This study tests whether a supplement called resveratrol can positively affect estrogen-related markers in postmenopausal women with stable coronary artery disease. It may help understand how this supplement could support heart health.
São Paulo, São PauloAges 45–70 - NCT05720260RecruitingPhase 2
Test immunotherapy plus hormone therapy and an AKT blocker
This trial tests whether combining immunotherapy, hormone therapy, and an AKT-blocking drug can control ER-positive advanced breast cancer in women whose cancer is resistant to hormone treatment. It may help shrink tumors and slow disease by targeting several pathways at once.
TaipeiAges 20 years+ - NCT06792201Recruiting
Sarcopenia study in women at different life stages
This trial looks at muscle loss (sarcopenia) in women who are pre-menopause or post-menopause, and whether hormone replacement therapy affects it. It aims to understand how muscle health changes over a woman's life.
BolognaAges 18–65 - NCT06383026Recruiting
Hormone Therapy Breast Cancer Screening Pilot
This pilot study tests a new way to screen for breast cancer in people who have taken hormone therapy (like estrogen, progesterone, or testosterone). It aims to include both men and women between 40 and 75, and younger people (30-39) with a family history of breast cancer.
Milwaukee, WisconsinAges 30–75 - NCT07401381RecruitingPhase 1
Injectable vs. oral letrozole in early breast cancer
This study compares a new injectable form of the drug letrozole with the standard oral pill. It aims to find out if the injection works as well as the pill for women who have already taken letrozole for their early breast cancer and have finished their initial treatment.
Beverly Hills, CaliforniaAges 18–80 - NCT07796880RecruitingPhase 2
Study of a new drug with hormone therapy before breast cancer surgery
This trial tests a new drug called culmerciclib when given with hormone therapy before breast cancer surgery. The goal is to see if this combination can shrink tumors and improve outcomes for patients with hormone-receptor-positive, HER2-negative breast cancer.
Guangzhou, GuangdongAges 18–70
What Menopausal Hormone Therapy is being studied for
Conditions with recruiting Menopausal Hormone Therapy studies.
Common questions
- Are there clinical trials studying Menopausal Hormone Therapy?
- Yes. Clin2 currently lists 35 recruiting studies that include Menopausal Hormone Therapy, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Menopausal Hormone Therapy trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Menopausal Hormone Therapy an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Menopausal Hormone Therapy or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.