Clinical trials
Hormone Replacement Therapy clinical trials
Below are recruiting hormone replacement therapy clinical trials, each written for real people, not researchers. We’re tracking 38 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05831709Recruiting
Hormone therapy and supervised exercise in menopausal women
This study looks at how hormone replacement therapy and a supervised exercise program may change body composition, heart health risk, and insulin sensitivity in postmenopausal women. It may help participants understand which combination works best for metabolic and cardiovascular health after menopause.
GhentAges 45–65 - NCT06280560Recruiting
IVF hormones and womb lining health study
This study looks at how IVF hormone treatments affect the womb lining and whether they cause aging cells to build up. It may help doctors improve IVF success rates.
ValenciaAges 18–45 - NCT07675213Recruiting
Uterine muscle movements and pregnancy after frozen embryo transfer
This trial explores how natural uterine contractions affect pregnancy success in women using hormone therapy for frozen embryo transfer. It may help doctors understand if uterine activity influences implantation.
Ho Chi Minh CityAges 18–42 - NCT06357442Recruiting
Comparing progesterone methods for young people on estrogen therapy
This study compares two ways to give progesterone to young people on estrogen replacement therapy to see how they affect the lining of the uterus. It will help find which approach may be safer and more effective for your health.
Aurora, ColoradoAges 12–25 - NCT06544473RecruitingPhase 4
Estrogen pill vs. patch for Turner syndrome
This trial compares oral and transdermal (patch) estrogen to find the right dose for women with Turner syndrome. It aims to see which method works best for hormone replacement.
Aarhus, Aarhus NAges 18–50 - NCT06570460RecruitingPhase 4
Estrogen pills vs. patch for Turner syndrome
This study compares two ways of taking estrogen (pills or a skin patch) in women with Turner syndrome to see which works better over time. It also includes healthy women for comparison.
Aarhus, Aarhus NAges 18–50 - NCT06679816RecruitingPhase 4
Hydrocortisone for hormone replacement in large pituitary tumor surgery
This trial tests hydrocortisone as hormone replacement therapy after surgery for large pituitary tumors. It aims to help patients maintain healthy cortisol levels during recovery.
Beijing, Beijing MunicipalityAges 18–70 - NCT06704516RecruitingPhase 1
HRT and fatty liver disease in menopausal women – a pilot study
This study tests whether starting hormone replacement therapy (HRT) improves liver health in women with menopause and fatty liver disease (MASLD). It aims to understand how HRT might help reduce fat in the liver.
Oxford, OxfordshireAges 18 years+ - NCT07278323RecruitingPhase 4
Hormone therapy for frozen shoulder
This study tests if hormone replacement therapy can help treat frozen shoulder. It is designed for people with frozen shoulder in just one shoulder who are not currently using hormones and have no history of hormone-sensitive cancer.
San Francisco, CaliforniaAges 40 years+ - NCT06497894RecruitingPhase 4
Hormone therapy for sleep in late menopause
This trial tests whether hormone replacement therapy (HRT) can improve sleep for women in late menopause who have insomnia. If you are in late menopause and struggle with poor sleep, this study may offer a treatment option.
BernAges 45–69 - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT04867317RecruitingPhase 3
Growth hormone treatment for veterans with mild TBI and deficiency
This Phase 3 study tests whether replacing growth hormone in veterans with mild traumatic brain injury (mTBI) and low adult growth hormone can improve quality of life. If you qualify, you’ll be screened with hormone blood tests and memory/mental health checks before starting treatment.
Birmingham, AlabamaAges 21–55 - NCT07406412Recruiting
Hormones and heart health before and after ovary removal
This study looks at how hormones affect heart health and metabolism in women who are having their ovaries removed (for non-cancer reasons). It will help researchers understand the changes that happen after surgery and how to better manage health during this transition.
HelsinkiAges 35–50 - NCT06372119Recruiting
Letrozole vs artificial cycle for embryo transfer preparation
This trial compares two ways to prepare the uterus for a frozen embryo transfer: using the hormone letrozole or a standard artificial cycle. The goal is to see which approach works better for people with irregular periods.
Ho Chi Minh City, Ho Chi Minh CityAges 18–42 - NCT07500922Recruiting
Menopause effects on brain activity study
This study looks at how menopause affects brain signals controlling movement. It offers combined hormone treatment to eligible women.
JyväskyläAges 50–59 - NCT07696351RecruitingPhase 4
Ultrasound-guided endometrial preparation for endometriosis
This trial tests whether a 2-3 month hormone treatment before a frozen embryo transfer improves pregnancy success in women with deep endometriosis. It may help your body prepare better for the embryo.
Nanjing, JiangsuAges 18–39 - NCT06972719Recruiting
Hormone therapy after ovary removal for BRCA mutation carriers
This study looks at giving hormone therapy after ovary and fallopian tube removal in women with a BRCA mutation. The goal is to help manage menopause symptoms while you are still premenopausal.
Chapel Hill, North CarolinaAges 19–50 - NCT07742488Recruiting
Statins and hormone therapy for cholesterol in menopause
This study looks at whether taking statins (cholesterol-lowering medicine) along with hormone replacement therapy (HRT) affects blood clotting in women going through menopause who have high cholesterol. It may help doctors understand how these medicines work together.
Pisa, ItalyAges 45–55 - NCT04121780RecruitingPhase 2
Growth hormone treatment for retired NFL players with low hormone
This Phase 2 study tests whether growth hormone replacement helps retired professional football players who have been diagnosed with growth hormone deficiency. You may be considered if you meet age and health requirements and have the specific hormone diagnosis.
Dearborn, MichiganAges 18–76 - NCT04167033Recruiting
Checking heart rhythm timing in women with premature ovarian insufficiency
This study measures how quickly the heart “recharges” between beats (often shown as QT timing). It compares women with premature ovarian insufficiency to healthy women to understand whether ovarian insufficiency is linked to heart rhythm differences.
BordeauxAges 18–40 - NCT06644794RecruitingPhase 3
Progesterone timing for frozen embryo transfer
This trial compares two ways of timing progesterone support for frozen embryo transfer in women with regular cycles. It aims to find which approach gives the best chance of pregnancy.
Jinan, ShandongAges 21–44 - NCT06851754RecruitingPhase 3
Hormone therapy for teens with early menopause
This trial tests whether hormone replacement therapy (HRT) helps protect bone health in teenagers with premature ovarian insufficiency (POI). It compares HRT to a placebo and also includes healthy volunteers for comparison.
Bethesda, MarylandAges 11–19 - NCT07436793RecruitingPhase 2
Progestin therapy before hysterectomy for endometrial cancer
This trial tests whether taking progestin (a hormone medication) before scheduled surgery can improve outcomes for women with a type of uterine cancer called endometrioid adenocarcinoma. You might be able to join if you are planning to have a hysterectomy and are open to hormone therapy before the procedure.
Iowa City, IowaAges 18 years+ - NCT07292857Recruiting
Respiratory infection risk in postmenopausal women on HRT or not
This study looks at how the risk of respiratory infections (like colds or flu) may differ in postmenopausal women who use hormone replacement therapy (HRT) and those who do not. You will wear a smartwatch for six months and track your health through a smartphone app.
BernAges 40–60
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Common questions
- Are there clinical trials for hormone replacement therapy?
- Yes. Clin2 currently lists 38 recruiting hormone replacement therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hormone replacement therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hormone replacement therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.