Treatment
Neoadjuvant Chemotherapy clinical trials
We’re tracking 327 recruiting studies that include Neoadjuvant Chemotherapy, each written for real people, not researchers, below.
Recruiting studies
- NCT07465497Enrolling by invitation
Preventing Chemo Brain with Prebiotics and Synbiotics
This trial tests whether taking a special blend of prebiotics and synbiotics (friendly bacteria and food for them) can help prevent or reduce memory and thinking problems that sometimes happen during chemotherapy for breast cancer.
Zapopan, JaliscoAges 18 years+ - NCT05033392RecruitingPhase 2
PD-1 therapy plus chemotherapy before stomach cancer surgery
This Phase 2 trial tests whether adding a PD-1 antibody (JS001/toripalimab) to chemotherapy before surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction adenocarcinoma. It aims to help shrink the tumor and make surgery more effective.
Shenzhen, GuangdongAges 18–79 - NCT06741540Recruiting
TDCS for breast cancer patients with mild to moderate depression
This trial tests if transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can help improve mood and treatment outcomes in breast cancer patients with mild to moderate depression who are receiving neoadjuvant chemotherapy before surgery.
Hangzhou, ZhejiangAges 18–65 - NCT05200260RecruitingPhase 2
Surgery plus maintenance medicines for advanced ovarian cancer
This trial checks whether having surgery to remove as much tumor as possible, followed by ongoing targeted treatment, helps people with advanced ovarian (and related) cancers live longer and/or control cancer better. It specifically uses tumor-testing results to match patients and then continues treatment after surgery.
FoshanAges 18 years+ - NCT04744506Recruiting
Targeted removal of armpit nodes after chemotherapy for breast cancer
This trial studies a more targeted surgery to remove cancer-involved lymph nodes in the armpit after you finish chemotherapy before surgery. It may help doctors better remove affected nodes while avoiding unnecessary tissue removal.
Hangzhou, ZhejiangAges 18–85 - NCT07400523RecruitingPhase 3
Ribociclib for breast cancer with leftover disease after chemo
This trial tests ribociclib, a targeted therapy, for women with hormone receptor-positive, HER2-negative breast cancer who still have cancer cells in the breast or lymph nodes after initial chemotherapy. It aims to reduce the chance of cancer coming back.
Zhanjiang, GuangdongAges 18 years+ - NCT07379281Recruiting
Personalized chemo testing for bladder cancer
This trial tests whether using a patient's own tumor cells grown in a lab (organoids) can help doctors choose the best chemotherapy drugs before bladder cancer surgery. It may help find the most effective treatment for you.
JinanAges 18–80 - NCT07365592RecruitingPhase 1/Phase 2
Neoadjuvant therapy for locally advanced colorectal cancer
This trial tests a combination of chemotherapy, an immunotherapy drug (anti-PD-1 antibody), and sitagliptin before surgery for colorectal cancer that has not spread to other organs. The goal is to see if this approach can shrink the tumor and improve outcomes.
Hangzhou, ZhejiangAges 18–75 - NCT06035679Recruiting
Combination therapy before surgery for HER2-positive breast cancer
This trial tests a combination of targeted therapies and chemotherapy given before surgery for HER2-positive breast cancer. It aims to see if this approach helps shrink tumors and improve outcomes.
Fuzhou, FujianAges 18–75 - NCT07312578Enrolling by invitationPhase 2
Targeted drugs plus chemo before surgery for esophageal cancer
This trial tests a combination of two targeted drugs (nimotuzumab and camrelizumab) plus standard chemotherapy before surgery for people with esophageal squamous cell carcinoma. The goal is to see if this approach helps shrink the tumor and improve outcomes.
Beijing, Beijing MunicipalityAges 18–70 - NCT07263919RecruitingPhase 2
Chemo plus cadonilimab before surgery for esophageal cancer
This trial tests adding cadonilimab to standard chemotherapy before surgery for esophageal cancer that can be removed. It aims to see if this combination helps shrink the tumor and improve outcomes.
Xi'anAges 18–75 - NCT07248956RecruitingPhase 2
Chemo plus immunotherapy before surgery for throat cancer
This trial tests giving chemotherapy combined with an immunotherapy drug (finotonlimab) before surgery for locally advanced hypopharyngeal cancer. It aims to shrink the tumor enough to improve surgery outcomes.
Harbin, HeilongjiangAges 18–75 - NCT07226154Recruiting
Predicting chemo response in pancreatic cancer
This study looks at blood samples to see if we can predict how well pancreatic cancer responds to chemotherapy before surgery. It aims to help doctors choose the best treatment for each patient.
Duarte, CaliforniaAges 18 years+ - NCT07220512Recruiting
Exercise help for ovarian, fallopian, or endometrial cancer
This trial tests a special exercise program during chemotherapy before surgery. It may help patients with certain gynecologic cancers get stronger and better prepared for treatment.
Winston-Salem, North CarolinaAges 55 years+ - NCT07209189RecruitingPhase 2
Chemo and immunotherapy before surgery for head and neck cancer
This trial tests a combination of chemotherapy and an immunotherapy drug called Toripalimab before surgery for certain head and neck cancers. The goal is to see if this approach can reduce the extent of treatment needed while still being effective.
Baltimore, MarylandAges 18 years+ - NCT07202845Recruiting
Predicting chemo response in bladder cancer with MRI
This trial uses special MRI scans to see how well bladder cancer responds to chemotherapy before surgery. It may help doctors know early if the treatment is working.
AsyutAges 18 years+ - NCT06225284RecruitingPhase 2
Chemotherapy with or without hormone drug for premenopausal TNBC
This trial tests whether adding a hormone-blocking drug (GnRH agonist) to standard chemotherapy before surgery helps premenopausal women with triple-negative breast cancer. It aims to improve treatment outcomes by targeting hormones that may fuel tumor growth.
TaipeiAges 18 years+ - NCT07159711Recruiting
Heart monitoring study for esophageal cancer surgery
This study tests a non-invasive heart monitor (seismocardiography) to see if it can predict how well patients recover after esophageal cancer surgery. The goal is to improve surgical planning and outcomes.
GuildfordAges 18 years+ - NCT07125209Recruiting
Chemotherapy and thinking for ovarian cancer
This study looks at how chemotherapy given before surgery for ovarian cancer may affect thinking and memory. It helps doctors understand the cognitive side effects of treatment so they can better support patients.
Madison, WisconsinAges 18 years+ - NCT07098026Recruiting
Herbal mixture plus chemo before surgery for advanced stomach cancer
This trial tests whether adding an herbal mixture (Shenqi Fuwei Mixture) to standard chemotherapy before surgery can help treat locally advanced stomach cancer. It is for people whose cancer has not spread to distant sites and who are healthy enough to undergo treatment and surgery.
Changsha, HunanAges 18–75 - NCT07104149RecruitingPhase 2
Chemo plus immunotherapy before surgery for cervical cancer
This trial tests adding a new immunotherapy drug (cadonilimab) to standard chemotherapy before surgery for locally advanced cervical cancer. The goal is to see if this combination helps shrink the tumor more effectively before surgery.
Zhengzhou, HenanAges 18–75 - NCT07070622RecruitingPhase 3
Organ preservation for low rectal cancer after chemo
This trial tests whether chemotherapy alone can help avoid surgery for low rectal cancer. It is for people with tumors close to the anus that haven't spread far, and who haven't had prior cancer treatment.
Chengdu, SichuanAges 18–80 - NCT07055841RecruitingPhase 2
Study of PD-L1 antibody plus chemo before surgery for head and neck cancer
This trial tests whether adding a PD-L1 antibody (Adabelimab) to standard chemotherapy before surgery can help treat advanced head and neck squamous cell carcinoma. It is for people who have not had treatment for this cancer before and are well enough to undergo the therapy.
Jinan, ShandongAges 18–85 - NCT04824027Recruiting
Breast ultrasound testing during chemotherapy for breast cancer
This study looks at how breast tissue changes during chemotherapy given before surgery (neoadjuvant therapy). It may help doctors better understand treatment effects by taking special breast measurements.
New York, New YorkAges 18 years+
Common questions
- Are there clinical trials studying Neoadjuvant Chemotherapy?
- Yes. Clin2 currently lists 327 recruiting studies that include Neoadjuvant Chemotherapy, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Neoadjuvant Chemotherapy trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Neoadjuvant Chemotherapy an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Neoadjuvant Chemotherapy or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.