Chemo plus immunotherapy before surgery for throat cancer
Treatments studied
Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.
This trial tests giving chemotherapy combined with an immunotherapy drug (finotonlimab) before surgery for locally advanced hypopharyngeal cancer. It aims to shrink the tumor enough to improve surgery outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must not have had any previous treatment for this cancer.
- Your cancer must be stage III to IVA and considered removable by surgery.
- You must have a good performance status (ECOG 0-2, meaning you are up and active most of the day).
- You cannot be pregnant or breastfeeding.
- You must not have had another cancer in the past.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests adding an immunotherapy drug (PD-1 inhibitor) to chemotherapy before surgery for advanced laryngeal or hypopharyngeal cancer. The goal is to see if this combination shrinks tumors more and improves outcomes for patients who need their entire voice box removed.
This trial tests a combination of an immunotherapy drug (adebrelimab) plus two chemotherapy drugs (TP regimen) before surgery for hypopharyngeal cancer that is locally advanced but hasn't spread. The goal is to shrink the tumor and improve surgical outcomes.
This trial tests a combination of an immunotherapy drug (penpulimab) with chemotherapy for people with advanced hypopharyngeal cancer that can still be removed with surgery. The goal is to see if this combination shrinks tumors and improves outcomes before surgery.
This trial tests whether adding immunotherapy before surgery, followed by either radiation or organ-preserving surgery, can improve outcomes for people with locally advanced laryngeal or hypopharyngeal cancer. It may help avoid complete removal of the voice box.
This trial tests whether giving a type of immunotherapy (PD-1 inhibitor) together with chemotherapy before surgery can help treat advanced laryngeal and hypopharyngeal squamous cell carcinoma. It aims to improve outcomes for patients whose cancer hasn't spread to distant organs.
This trial tests a new combination of drugs (an immunotherapy called a PD-1 inhibitor, cetuximab, and platinum chemotherapy) given before surgery for advanced throat cancer that requires removing the voice box. The goal is to see if this treatment shrinks the tumor and improves outcomes.
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