Treatment
Systemic therapy clinical trials
We’re tracking 397 recruiting studies that include Systemic therapy, each written for real people, not researchers, below.
Recruiting studies
- NCT07355972RecruitingEarly Phase 1
CT1195E cell therapy for progressive scleroderma
This trial tests a new cell therapy called CT1195E for people with refractory or progressive systemic sclerosis (scleroderma) that also affects the lungs. It aims to see if the treatment is safe and can help slow or stop the disease.
Wuhan, HubeiAges 18–60 - NCT06849180Recruiting
Personalized Treatment for Advanced Combined Liver Cancer
This study is for people with a rare and advanced liver cancer called combined hepatocellular cholangiocarcinoma (CHC). Doctors will use information from your tumor and health history to find the best treatment approach for your specific cancer type.
Nanjing, JiangsuAges 18 years+ - NCT05621837Recruiting
Biomarker study to guide treatment for several advanced cancers
This study measures how strongly your immune system is being suppressed and uses that information to help personalize cancer treatment. It mainly looks at people with certain advanced cancers and needs tumor tissue and follow-up to check possible immune-related markers.
MilanAges 18–90 - NCT06951672Recruiting
Testing a new mitral valve repair device
This trial tests a new device called AMEND™ that is placed through a vein in the leg to repair a leaky mitral valve without open-heart surgery. It is for people with significant mitral regurgitation who are at high risk for surgery.
Phoenix, ArizonaAges 21 years+ - NCT06775912RecruitingEarly Phase 1
CAR-T cell therapy for autoimmune diseases
This trial tests a new CAR-T cell therapy that targets two proteins (CD19 and BCMA) on immune cells. It's designed for people with certain autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's syndrome that are not controlled by standard treatments.
Lianyungang, JiangusAges 18–70 - NCT06200259Recruiting
Reducing Bowel Side Effects in Prostate Cancer Proton Therapy
This study tests a way to reduce stomach and bowel side effects of proton therapy for prostate cancer. It uses special software to place the proton beam more carefully, which may protect nearby organs.
Knoxville, TennesseeAges 18 years+ - NCT05893940Recruiting
Gentle physical stimulation during blood cancer transplant
This trial tests whether a low-intensity mechanical (physical) stimulation is safe and helpful for people with certain blood cancers who are about to have a transplant. It may affect how you do during or after treatment, and participation is voluntary with informed consent.
Buffalo, New YorkAges 18 years+ - NCT05443425RecruitingPhase 1
Leflunomide plus steroids for acute graft-versus-host disease
This early-phase trial tests whether adding leflunomide to standard steroid treatment can better control acute graft-versus-host disease (aGvHD) after a stem cell transplant. It may help reduce the immune reaction that damages the body while keeping treatment safe and manageable.
Duarte, CaliforniaAges 18 years+ - NCT01719055Recruiting
Long-term follow-up for Boston Scientific pain nerve stimulation
This study looks at how well a Boston Scientific nerve stimulation device works over the long term for pain in everyday care. You may be able to join if you’re already being set up to use one of these approved systems and can reliably report your pain outcomes.
Phoenix, ArizonaAges 18 years+ - NCT07452640Recruiting
Comparing two non-surgical gum treatments for advanced periodontitis
This study compares two methods for treating advanced gum disease (periodontitis) without surgery: one uses a special ultrasound device (Vector® system) and the other uses small hand tools (Mini-Five curettes). The goal is to see which cleans deeper pockets better and helps gums heal.
AnkaraAges 18–65 - NCT05903235Recruiting
VR and mirror therapy for arm recovery after stroke
This trial tests a mix of virtual reality (VR) and mirror therapy to help improve arm movement after a stroke. You may be asked to use the technology and give feedback, and the study may compare it with other care approaches to see if it helps more.
Taoyuan CityAges 20–80 - NCT07085104RecruitingPhase 1
Study of ALLO-329 for lupus, myositis, or scleroderma
This trial tests a new one-time cell therapy (ALLO-329) made from donor cells to target and calm overactive immune cells in people with lupus, myositis, or scleroderma that hasn't improved with usual medications. It aims to see if this treatment is safe and can help reduce disease activity.
Phoenix, ArizonaAges 18–74 - NCT07185555Recruiting
Low-carb diet for type 1 diabetes and obesity
This study tests a very low-energy ketogenic diet (a special low-carb, low-calorie diet) in adults with type 1 diabetes and obesity who use an automated insulin pump. It aims to see if this diet helps with weight loss and blood sugar control.
Bari, ItalyAges 18–99 - NCT06316791RecruitingEarly Phase 1
CNCT19 CAR-T therapy for refractory autoimmune diseases
This early-phase study tests a new CAR-T cell therapy (CNCT19) for people with certain autoimmune diseases that have not responded to standard treatments. It targets a protein called CD19 on immune cells to help reset the immune system and reduce disease activity.
Zhengzhou, HenanAges 18–70 - NCT07339332RecruitingEarly Phase 1
CAR-T cell therapy for moderate to severe lupus
This study tests whether a new CAR-T cell treatment (called CT1195E) can help people with lupus that hasn't improved with standard medicines. CAR-T cells are specially trained immune cells that seek out and destroy certain faulty immune cells, which may reduce lupus symptoms. The trial is for people with moderate to severe active lupus affecting organs like the kidneys, heart, or blood system.
Wuhan, HubeiAges 18–65 - NCT06920433RecruitingEarly Phase 1
Targeted cell therapy for tough lupus with kidney involvement
This early-phase trial tests a special immune cell therapy (UCAR T-cells) that targets two proteins (CD19 and BCMA) on the surface of lupus B cells. It is for people with difficult-to-treat lupus that affects the kidneys (lupus nephritis) who have not gotten better with standard treatments.
Hangzhou, ZhejiangAges 18 years+ - NCT05011045Recruiting
Brain radiation study tracking thinking and memory changes
This study looks at how whole-brain radiation affects thinking, memory, and other brain function in people with blood cancers that involve the brain. It may help doctors understand what to expect and which supportive treatments or monitoring could be useful.
Houston, TexasAges 18 years+ - NCT00991094Recruiting
Study follow-up after proton radiation treatment
This study collects information about both short-term and long-term side effects in people who receive proton radiation. It may help doctors better understand what happens to normal tissues over time and improve follow-up care.
Houston, TexasAges 18 years+ - NCT07542470Enrolling by invitationPhase 4
Cold and compression therapy after spinal surgery
This study compares a new cold and compression device (NICE1) to standard care after spinal surgery to see if it reduces pain and swelling. If you're having spine surgery, this trial tests whether keeping the area cold and compressed helps you recover better.
Sarasota, FloridaAges 18 years+ - NCT07413874Recruiting
Music therapy over video for depression and hormone disorder
This trial tests if telehealth music therapy can help adults who have both an endocrine autoimmune disease and depression. You'll join sessions from home using Zoom.
Boone, North CarolinaAges 18–65 - NCT06796504Recruiting
Nerve stimulation for relapsing-remitting multiple sclerosis
This trial tests a device that stimulates a nerve in the neck, which may help repair the protective coating around nerves in the brain and spinal cord. It is for people with relapsing-remitting MS who are stable on their current medication and have some vision problems due to MS.
Irvine, CaliforniaAges 22–60 - NCT07876908Recruiting
Magnetic brain therapy for older adults with hard-to-treat depression
This trial tests a new intensive magnetic brain treatment (SAINT) for older adults whose depression has not improved with standard treatments. It aims to see if this treatment can also help with memory concerns, which are common in this group.
Costa Mesa, CaliforniaAges 65 years+ - NCT06324682Recruiting
Comparing heart pacemaker types for better treatment
This trial looks at different ways to pace the heart (like left, right, or both sides) to see which works best for people who need a pacemaker. If you have a heart condition requiring a pacemaker, this study may help find the safest and most effective option for you.
Ferrara, FEAges 18 years+ - NCT07534358Recruiting
VA and Community Care Coordination for Suicide Prevention
This study tests whether coordinated case management between VA and community care providers can better support veterans at risk for suicide. You'll work with a care coordinator who helps make sure your VA and non-VA doctors communicate and work together.
Aurora, ColoradoAges 18–80
Common questions
- Are there clinical trials studying Systemic therapy?
- Yes. Clin2 currently lists 397 recruiting studies that include Systemic therapy, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Systemic therapy trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Systemic therapy an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Systemic therapy or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.