Treatment
Systemic therapy clinical trials
We’re tracking 408 recruiting studies that include Systemic therapy, each written for real people, not researchers, below.
Recruiting studies
- NCT06375083RecruitingPhase 2
Computer therapy for suicide prevention and depression in Veterans
This trial tests two different computer-based therapy programs for Veterans: one for preventing suicide and one for treating depression. Both programs are designed to be done at home on your computer or tablet.
Aurora, ColoradoAges 18–65 - NCT04702256RecruitingPhase 3
Treating lupus kidney inflammation with or without extra steroid tablets
This trial tests whether adding standard oral steroid tablets to mycophenolate helps lupus nephritis (inflammation of the kidneys) more than using obinutuzumab plus mycophenolate, without extra oral steroids. It may help find a treatment plan that controls active kidney disease while changing how much steroid is used.
ParisAges 14 years+ - NCT06052436RecruitingPhase 1/Phase 2
Treg cell therapy for COVID-19 and acute respiratory distress
This trial tests a new cell therapy using Treg cells from thymic tissue to calm an overactive immune response in severe COVID-19 and ARDS. It aims to improve breathing and reduce inflammation.
Madrid, MadridAges 18–65 - NCT06919029Recruiting
New insulin pump study for children with new type 1 diabetes
This study tests a new insulin pump system (MiniMed 780G) in children aged 7-17 who were recently diagnosed with type 1 diabetes. It aims to see if this pump helps control blood sugar better and improves quality of life compared to standard insulin shots or older pumps.
AthensAges 7–17 - NCT06991114RecruitingPhase 2
AlloNK and rituximab for relapsing rheumatologic diseases
This trial tests a new natural killer (NK) cell therapy called AlloNK given with rituximab for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, inflammatory myopathies, or systemic sclerosis) that have not responded well to standard treatments. The goal is to see if this combination can better control the disease.
Tuscaloosa, AlabamaAges 18 years+ - NCT06688422Recruiting
Using a breathing device during lung cancer treatment
This trial tests if using a simple breathing exercise device (called an incentive spirometer) during chemo and radiation for advanced lung cancer can help improve breathing outcomes and overall recovery.
Camden, New JerseyAges 18 years+ - NCT06237218Recruiting
Occupational therapy to prevent falls in older adults with dementia
This program tests whether a special type of home-based occupational therapy (called COTID) can help older adults with dementia avoid falling again after a fall that sent them to the hospital. It compares this new approach to usual occupational therapy care.
LimogesAges 75 years+ - NCT07361094RecruitingPhase 1
CAR-T therapy for autoimmune disease after prior treatment
This trial tests a new CAR-T cell therapy that targets two proteins (CD19 and BCMA) on immune cells. It is for people with certain autoimmune diseases (like lupus or scleroderma) that have not responded well to standard treatments or have relapsed after prior cell therapy.
BeijingAges 18–70 - NCT06116110Recruiting
Long-term follow-up after gene therapy treatment
This study is a long-term follow-up for people who previously received a gene therapy treatment called zamtocabtagene autoleucel in a Miltenyi Biomedicine-sponsored clinical study. It helps researchers monitor your health over time after the treatment.
Gilbert, ArizonaAges 18 years+ - NCT04771520RecruitingPhase 2
Avapritinib for tumors with specific KIT or PDGFRA changes
This Phase 2 trial studies avapritinib, a targeted medicine, for people whose cancer has specific KIT or PDGFRA genetic changes. It may help shrink or slow growth of certain advanced cancers, including some brain tumors, when standard treatments have not worked or for specific glioblastoma cases.
Houston, TexasAges 18 years+ - NCT06817590RecruitingPhase 1
Nucleoside therapy for telomere disorders
This trial tests a nucleoside therapy (dC/dT) for people with telomere biology disorders, which cause premature aging and problems like low blood counts, lung or liver issues. The goal is to see if the treatment can help manage these symptoms.
Boston, MassachusettsAges 1–70 - NCT04552080RecruitingPhase 4
Antibiotics around sinus and bone graft implants to prevent problems
This trial studies whether taking antibiotics through the body (systemic antibiotics) after sinus-lift and bone-graft dental implant surgery can reduce post-surgery complications and improve patient comfort. It compares outcomes that matter to patients after implant placement using guided bone regeneration and a sinus floor elevation.
GrazAges 21 years+ - NCT07331285Recruiting
Genio therapy study for moderate to severe sleep apnea
This trial studies a device called Genio that is implanted to help keep your airway open while you sleep. It is for people with moderate to severe sleep apnea who have not been helped by other treatments.
Miami, FloridaAges 22 years+ - NCT06868459Enrolling by invitation
Study of PED-TAE treatment for thyroid disease
This study tracks people who have already received a new type of thyroid treatment called PED-TAE (pressure-enabled embolization) using the TriNav system. It aims to see how well this procedure works for various thyroid conditions, including overactive thyroid, large goiters, and benign nodules causing symptoms.
Sarasota, FloridaAges 18–89 - NCT05686798RecruitingPhase 1
Gene therapy plus radiation for recurring brain tumor
This early-phase study tests a “suicide gene” therapy delivered by a virus along with radiation for adults whose high-grade brain tumor has come back or grown again. The goal is to see if the treatment is safe and can help control the tumor.
Detroit, MichiganAges 18 years+ - NCT07163221Recruiting
At-home ultrasound therapy for rheumatoid arthritis
This trial tests if a device that uses ultrasound waves, used at home, can help treat rheumatoid arthritis (RA). It is for people with moderate to severe RA who still have symptoms despite taking standard medications.
Glendale, ArizonaAges 18 years+ - NCT05564377RecruitingPhase 2
Find targeted cancer treatments using genetic testing
This study matches people with advanced solid tumors to targeted treatment plans based on genetic testing. It also requires tumor sample testing to help doctors choose the most promising therapy for your specific tumor changes.
Birmingham, AlabamaAges Any age - NCT06059391RecruitingPhase 2
Vaccine for stem cell donors to prevent CMV
This trial tests whether giving a CMV vaccine to stem cell donors can help protect recipients from CMV infection after transplant. It is for adults with specific blood cancers who are CMV-positive and have a matched related donor.
Duarte, CaliforniaAges 18–75 - NCT06706921RecruitingPhase 4
Predicting treatment success with PET scans in prostate cancer
This study looks at whether a special PET scan can help predict how well a targeted radiation therapy (LuPSMA) works in men with advanced prostate cancer that has spread. You would get several PET scans before and after treatment to see if the scan results can forecast your outcome.
Los Angeles, CaliforniaAges 18 years+ - NCT03959085RecruitingPhase 3
Inotuzumab plus chemotherapy for high-risk childhood leukemia
This Phase 3 trial tests whether adding inotuzumab to standard post-induction chemotherapy improves outcomes for children and young teens with high-risk B-ALL, mixed phenotype acute leukemia (MPAL), or certain high-risk B-LLy. It may help by targeting leukemia cells more directly, but participation depends on specific age, lab results, and medical history rules.
Birmingham, AlabamaAges 12 months–25 years - NCT04684368RecruitingPhase 2
New treatment study for children and young adults with NGGCT brain tumors
This Phase 2 study tests a new treatment approach for certain brain tumors called NGGCT in children and young adults. It may help improve outcomes by targeting tumors in specific brain locations and using tumor marker tests to guide care.
Birmingham, AlabamaAges 3–29 - NCT04221893Recruiting
Radiation for tumors that keep growing despite immunotherapy
This study tests whether targeted radiation can help people with metastatic gastrointestinal cancers whose cancer is still getting worse on immunotherapy. It focuses on treating a small number of spots that are progressing while keeping other spots that are safer to leave alone.
San Francisco, CaliforniaAges 18 years+ - NCT05969860RecruitingPhase 2
Home cancer treatment vs clinic treatment for advanced cancer
This Phase 2 trial compares giving certain standard cancer infusions at home versus in a clinic. It may help people avoid clinic visits while still receiving the same cancer treatment safely.
Jacksonville, FloridaAges 18 years+ - NCT05092373RecruitingPhase 1
Tumor treating device plus targeted or immune drugs for advanced cancers
This Phase 1 study tests whether a tumor treating fields device works better when added to standard cancer drugs. It may help people with advanced solid tumors in the chest or belly, especially when standard treatment didn’t work or can’t be tolerated.
Houston, TexasAges 18 years+
Common questions
- Are there clinical trials studying Systemic therapy?
- Yes. Clin2 currently lists 408 recruiting studies that include Systemic therapy, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Systemic therapy trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Systemic therapy an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Systemic therapy or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.