Treatment
Optimal medical therapy clinical trials
We’re tracking 119 recruiting studies that include Optimal medical therapy, each written for real people, not researchers, below.
Recruiting studies
- NCT03563417Recruiting
CTO treatment vs medicines after heart scan
This trial studies whether opening a blocked coronary artery (a CTO) helps people more than staying on the best available heart medicines after an initial 3-month treatment period. It uses heart imaging to confirm there is reduced blood flow in the area supplied by the blockage.
Aarhus NAges 18 years+ - NCT05776797Recruiting
Ablation vs best medicines for CRT patients with permanent atrial fibrillation
This trial compares two approaches—an AV junction ablation procedure versus continued best medical treatment—in people who already have a heart device for heart failure (CRT) but still have ongoing permanent atrial fibrillation. It aims to improve how well your heart rhythm is controlled and how effectively the device can pace your heart.
Liberec, Liberec RegionAges 18–85 - NCT07691307Recruiting
TruGamma tricuspid valve replacement study
This trial tests a new device called TruGamma to replace the tricuspid valve without open-heart surgery. It is for older adults with severe tricuspid regurgitation who cannot have surgery and still have symptoms despite medication.
Beijing, Beijing MunicipalityAges 65 years+ - NCT02845531RecruitingPhase 4
Defibrillator device vs medicines for a rare heart spasm after arrest
This trial compares an implantable defibrillator device plus best care versus best medicines alone in people who survived a cardiac arrest caused by a specific abnormal heart rhythm. It focuses on variant angina, where a heart-spasm problem can trigger dangerous rhythm events, to see which approach prevents future events.
Bucheon-siAges 18 years+ - NCT06588231Recruiting
Personalized exercise for older adults with heart disease
This study tests whether a personalized exercise program can help older people (60–75) with stable coronary heart disease improve their heart health. You would work with healthcare professionals to get an exercise plan tailored to your condition.
Nanjing, JiangsuAges 60–75 - NCT04097145Recruiting
Heart valve repair for severe leaking tricuspid valve
This trial tests a catheter-based procedure (done through the blood vessels) to repair a severely leaky tricuspid valve. It may help people with symptoms or past hospitalizations from tricuspid valve leakage who are higher-risk for standard surgery.
Phoenix, ArizonaAges 18 years+ - NCT04606459Recruiting
Device trial for hard-to-treat heart chest pain from small vessels
This trial tests whether a small pressure-reducing device placed in a heart vein (the coronary sinus) can reduce symptoms in people with ongoing chest pain from tiny blood vessel problems. It is for angina that has not improved despite standard heart medicines, and only if special heart tests show reversible reduced blood flow.
Mainz, Rhineland-PalatinateAges 18–85 - NCT04691037Recruiting
CT heart scan to guide care for stable chest pain
This trial studies whether a CT heart scan (CCTA) can better guide treatment decisions for people with stable chest pain caused by blocked heart arteries. It may help your care team choose the next best step based on scan results.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05665608Recruiting
Prevent sudden death after a heart attack with a defibrillator
This trial studies whether implanting a defibrillator (ICD) soon after a heart attack can lower the risk of sudden cardiac death in people with weaker heart pumping and symptoms of heart failure. It compares strategies around defibrillator implantation, aiming to improve safety and outcomes.
FeldkirchAges 18 years+ - NCT05834803Recruiting
Stenting narrowed kidney artery to help high-risk patients
This trial studies whether placing a small stent in a severely narrowed kidney artery can improve outcomes for people with high-risk, artery-hardening kidney blood-flow problems. It focuses on people whose high blood pressure or kidney function has been getting worse despite multiple medications.
Aarhus NAges 18 years+ - NCT06152107Recruiting
BTVA Treatment for Severe Emphysema Study
This study tests a new bronchoscopic treatment called BTVA for people with severe emphysema. It uses heat to shrink damaged parts of the lung to improve breathing.
Zhengzhou, HenanAges 18 years+ - NCT03756870Recruiting
Stent procedure vs best medical care for blocked heart arteries
This trial studies whether opening a completely blocked heart artery (a CTO) with a procedure and stent helps reduce areas of low blood flow in the heart, compared with the best medicines alone. It uses heart scans to find people likely to benefit and then checks results again at 6 months.
AmsterdamAges 18 years+ - NCT07254572RecruitingPhase 4
Comparing diabetes drugs for heart health in prediabetes
This trial tests whether certain diabetes medications can help prevent worsening of heart disease in people who have prediabetes (higher than normal blood sugar, but not yet diabetes). It may be a good fit if you have known coronary artery disease and prediabetes.
WarsawAges 18–80 - NCT06412432Enrolling by invitation
Exercise and rehab for heart amyloidosis
This study tests whether a supervised exercise and rehabilitation program can help people with a specific type of heart amyloidosis (ATTRwt) feel better and improve their heart function. It may be a good fit if you have stable heart failure and can safely exercise.
NaplesAges 18 years+ - NCT06788431RecruitingEarly Phase 1
Study of IMC-001 to stabilize heart artery plaque
This trial tests an investigational drug, IMC-001, to see if it can make artery plaques in the heart more stable and less likely to cause a heart attack. You may be eligible if you've recently had a heart attack or unstable angina and have a specific type of soft plaque in your arteries.
Nanyang, HenanAges 18–75 - NCT06903312RecruitingPhase 4
Removing the main kidney tumor during immunotherapy for advanced kidney cancer
This trial tests whether removing or burning (ablating) the main kidney tumor helps people with advanced kidney cancer who are already doing well on immunotherapy. Researchers want to see if combining local treatment with ongoing immunotherapy can improve outcomes.
RomaAges 18 years+ - NCT02716246RecruitingPhase 2/Phase 3
Gene therapy for MPS IIIA to slow brain decline
This trial tests a gene-transfer treatment (delivered into the spinal fluid) for children with MPS IIIA, a rare genetic condition. It aims to improve or slow down brain and developmental changes caused by a missing enzyme.
Columbus, OhioAges Any age - NCT07435662Recruiting
Improving heart failure care in Denver
This study aims to improve heart failure treatment for people who have limited access to care in Denver. If you have heart failure with reduced pumping ability and are a patient in the Denver Health system, this trial may help find better ways to manage your condition.
Denver, ColoradoAges 18 years+ - NCT07208825Recruiting
Conservative care for complex regional pain syndrome
This study tests whether a conservative treatment plan can help people with complex regional pain syndrome (CRPS), a condition where pain lasts longer than expected after an injury. You may qualify if you have had CRPS symptoms for up to 5 years and are between ages 18 and 70.
Oulu, North OstrobothniaAges 18–70 - NCT05865600Recruiting
PET/CT guided planning for treatment in chronic coronary disease
This trial uses a heart scan (PET/CT) to better estimate blood flow in people with long-term coronary artery disease. It aims to help doctors choose the best treatment strategy and decide who may need more invasive testing or procedures.
Herning, Central JutlandAges 18 years+ - NCT07352891Recruiting
Digital remote management vs. usual care for heart failure
This trial tests whether using a remote monitoring platform to help manage medications improves outcomes in people with heart failure and reduced pumping function. It compares this approach to standard follow-up care.
BeijingAges 18 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Phoenix, ArizonaAges 18 years+ - NCT07671885RecruitingPhase 3
Hormone therapy before surgery for premenopausal breast cancer
This trial tests if giving hormone-blocking pills before surgery can help guide which treatments you need after surgery. It is for premenopausal women with early-stage, hormone-sensitive breast cancer.
AkitaAges 18 years+ - NCT04832620Recruiting
Using MRI-guided planning to improve proton radiation for rare bone tumors
This trial is testing a better way to plan proton radiation using MRI images, aiming to deliver treatment more accurately for chordoma or chondrosarcoma in the spine/sacrum area. You may benefit if the trial’s planning method helps target the tumor while sparing nearby healthy tissue.
Delft, South HollandAges 50 years+
What Optimal medical therapy is being studied for
Conditions with recruiting Optimal medical therapy studies.
Common questions
- Are there clinical trials studying Optimal medical therapy?
- Yes. Clin2 currently lists 119 recruiting studies that include Optimal medical therapy, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Optimal medical therapy trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Optimal medical therapy an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Optimal medical therapy or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.