Treatment clinical trials

A new drug combo for advanced bile duct cancer

This trial tests a combination of two drugs, sacituzumab tirumotecan and pucotenlimab, for people with advanced bile duct cancer (including gallbladder cancer) that cannot be removed by surgery or has spread. The goal is to see if this treatment is safe and works well, especially for those with a protein called TROP2 on their cancer cells.

Talk therapy for PTSD and tinnitus after concussion

This study tests a type of talk therapy for people with both PTSD and chronic tinnitus that started after a mild head injury. The therapy aims to help reduce symptoms of both conditions together.

Study of stem cell transplant and CD7-CART for T-cell lymphoma

This trial combines your own stem cells (collected before) with a special immune cell therapy (CD7-CART) to treat T-cell lymphoma or leukemia. It may help people with high-risk or hard-to-treat disease.

Metabolically armed TIL therapy for advanced solid tumors

This trial tests a new cell therapy (Meta10-TIL) made from your own immune cells that were trained to attack cancer. It is for people with advanced solid tumors that have stopped responding to standard treatments, including cervical, liver, lung, breast, ovarian, head and neck, or colorectal cancer.

Comparing two types of retainers after braces

This study compares two types of retainers (a wire that keeps teeth in place) after braces are removed: one that is directly bonded to the teeth and one that is made indirectly. It looks at which type keeps gums healthy, lasts longer, and how likely it is to break.

SLV-324 for advanced solid tumors that have spread

This phase 1 trial tests a new drug called SLV-324 for people with solid tumors that have spread and are no longer responding to standard treatments. The goal is to see if the drug is safe and works against the cancer.

Targeted drugs plus chemo for HER2-positive rectal cancer

This trial tests whether a combination of two targeted drugs (trastuzumab and pertuzumab biosimilars) plus chemotherapy can shrink advanced HER2-positive rectal cancer before surgery. It aims to improve response and potentially reduce the need for more aggressive treatments.

Breathing muscle training for hospitalized heart failure patients

This trial tests whether training the muscles you use to breathe can help people recover while in the hospital for heart failure. If you are stable enough, you may be able to join.

Numbing technique for tooth removal in children under anesthesia

This study tests a special numbing technique (intraosseous anesthesia) for removing permanent back teeth in children who are already under general anesthesia for dental treatments. The goal is to see if it helps reduce pain after the procedure.

Chemotherapy and transplant for adult acute myeloid leukemia

This trial tests a combination of chemotherapy and stem cell transplant for adults with acute myeloid leukemia (AML) that is not a specific subtype called APL. It aims to see if this approach is more effective than standard treatments.

Balance and Botox for Stiff Knee Gait

This study tests whether botulinum toxin (Botox) injections into the rectus femoris thigh muscle can improve balance and walking in people with a stiff knee gait (a common problem after stroke, brain injury, or multiple sclerosis).

Study of lung cancer treatment patterns in the real world

This study looks at the medical records of people with advanced non-small cell lung cancer to understand what treatments they received and whether those treatments follow official guidelines. It may help doctors learn how to improve care for future patients.

Robot vs. open surgery for chronic pancreatitis pain

This study compares robot-assisted vs. open surgery for treating chronic pancreatitis pain. It aims to see which approach works better for people with a dilated pancreatic duct who need relief from severe symptoms.

Stem cell transplant plus CAR-T for aggressive myeloma

This trial tests combining a stem cell transplant with a special immune cell therapy (BCMA CAR-T) to treat very aggressive multiple myeloma. The goal is to see if this powerful one-two punch can help people whose myeloma is hard to control.

Secukinumab for moderate to severe hidradenitis suppurativa

This study tests a drug called secukinumab (a type of biologic that targets inflammation) for people with moderate to severe hidradenitis suppurativa (HS). It may be an option if you have tried other treatments and they didn't work well.

Boric acid inserts for treating yeast infections in women

This study tests boric acid vaginal inserts as a treatment for yeast infections. It is for females who have a current yeast infection, are not pregnant, and are willing to use specific birth control methods.

A new combo therapy for advanced pancreatic cancer

This trial tests a combination of three drugs (QL1706, lenvatinib, and chemotherapy) as the first treatment for people with advanced pancreatic cancer that has spread to other parts of the body. It aims to see if this combination is safe and effective.

Golidocitinib with immunotherapy for extensive-stage small cell lung cancer

This trial tests a combination of golidocitinib (a targeted pill) and a PD-1 inhibitor (a type of immunotherapy) as a maintenance treatment after initial chemotherapy. It may help keep your lung cancer from growing longer.

Yangxinshi tablets for heart disease with reduced heart function

This trial tests whether Yangxinshi tablets can help people with coronary heart disease and some degree of heart failure. It looks at improving heart function and safety over the treatment period.

A Trial of Adebrelimab Plus (SHR-A1811/SHR-A1904 With Chemotherapy) or SHR-8068 as Treatment for Gastric/GEJ Cancer

Using ONCOhabitats to plan brain tumor surgery

This study tests a computer tool called ONCOhabitats that helps doctors plan surgery and treatment for a type of aggressive brain tumor called glioblastoma. By using your MRI scans, the tool may help guide the surgeon to remove as much tumor as possible while sparing healthy brain tissue.

Study of SHR-A1811 for triple-negative breast cancer

This study tests a new drug called SHR-A1811 for people with triple-negative breast cancer that has spread or come back. It looks at whether the drug can help shrink tumors or slow the cancer's growth.

A Vaccine (STEMVAC) With Standard Endocrine-Based Therapy or Chemotherapy for the Treatment of Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer

Nerve block for radiation pain during anal cancer treatment

This study tests a nerve block procedure (ganglion impar neurolysis) to reduce severe pain caused by radiation therapy for anal or perianal skin cancer. It may help you manage pain while you continue your cancer treatment.