Rapamycin for lymphatic malformations in children
Treatments studied
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This trial studies whether rapamycin can reduce problems caused by cervico-facial or chest (mediastinal) lymphatic malformations in children. It may help with pain and swallowing or breathing difficulties when standard “curative” treatment isn’t possible.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 0 to 18 and have a lymphatic malformation in the neck/face or chest
- Your symptoms cause ongoing pain or breathing/swallowing problems, and a scoring test is below 8
- Doctors think the malformation can’t be fully cured (or cure would be too risky)
- Your heart-strength functioning score is high enough: Karnofsky over 50% (age >10) or Lansky over 50% (age ≤10)
- Recent blood tests are adequate (counts for white blood cells, platelets, and hemoglobin; plus liver/bilirubin and albumin levels)
- You can safely take rapamycin with your current medicines (no certain immune-suppressing drugs or drug interactions)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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