Clinical trials
Lymphatic Malformation clinical trials
Below are recruiting lymphatic malformation clinical trials, each written for real people, not researchers. We’re tracking 15 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03243019RecruitingPhase 2
Rapamycin for lymphatic malformations in children
This trial studies whether rapamycin can reduce problems caused by cervico-facial or chest (mediastinal) lymphatic malformations in children. It may help with pain and swallowing or breathing difficulties when standard “curative” treatment isn’t possible.
LilleAges Up to 18 years - NCT05983159RecruitingPhase 2
Targeted therapy for slow-flow or fast-flow vascular malformations
This trial tests two targeted medicines for people with certain types of vascular malformations (abnormal blood vessels). If you have a slow-flow malformation, you may receive alpelisib; if you have a fast-flow malformation, you may receive mirdametinib. Genetic testing is needed to see if your malformation has a specific change that these drugs target.
Parkville, VictoriaAges 2 years+ - NCT06673290RecruitingPhase 2/Phase 3
Testing different doses of sirolimus for cystic lymphatic malformations
This trial tests different doses of sirolimus (a medication that slows cell growth) to find the best dose for treating cystic lymphatic malformations in children. It may help shrink the abnormal fluid-filled growths and improve symptoms.
Chengdu, SichuanAges 1–18 - NCT06437158RecruitingPhase 2
Bleomycin sclerotherapy for lymphatic malformations in children
This trial tests a medicine called bleomycin, injected into lymphatic malformations (abnormal fluid-filled growths) to shrink them. It is for children under 14 whose malformations are growing quickly, causing symptoms or problems, and cannot be removed by surgery alone.
Chengdu, SichuanAges Up to 14 years - NCT06892964Recruiting
Italian registry and biobank for ML patients
This study creates a national registry and biobank to collect medical information and biological samples from people with any type of ML, helping research into the condition.
RomaAges Up to 100 years - NCT05948943RecruitingPhase 2/Phase 3
Alpelisib for lymphatic malformations with a PIK3CA change
This trial tests alpelisib (a targeted medicine) for people who have lymphatic malformations (LyM) that cause symptoms and have a PIK3CA mutation. It may help shrink or control these lesions when other procedures are delayed until after the first 24 weeks.
Oakland, CaliforniaAges birth–100 years - NCT02399527Recruiting
Lymphatic problem registry for tracking outcomes
This study enrolls people with certain lymphatic (lymph fluid) conditions to collect information and track how they do over time. It may help doctors better understand outcomes and improve care.
Boston, MassachusettsAges Any age - NCT05871970RecruitingPhase 2
TARA-002 treatment for lymphatic cysts in children
This Phase 2 trial tests whether an injected medicine called TARA-002 placed inside lymphatic cysts can safely shrink lymphatic malformations in children. It may help especially when the cysts are mainly in the head, neck, or chest area.
Birmingham, AlabamaAges 6 months–18 years - NCT07285005RecruitingPhase 3
Study of an oral drug for venous, lymphatic, and certain overgrowth syndromes
This trial tests whether the study drug KP-001 can help reduce symptoms like pain, fatigue, or bleeding caused by certain vascular malformations (abnormal blood vessel growths) that can't be surgically removed or haven't responded to other treatments. It's for people age 2 and older with specific conditions such as common venous malformations, lymphatic malformations, or KTS/CLOVES syndrome.
Charleston, South CarolinaAges 2 years+ - NCT04861064RecruitingPhase 2
Weekly sirolimus for blood and lymph vessel malformations
This trial studies whether taking sirolimus once a week can improve blood vessel, lymph vessel, or mixed (venolymphatic) malformations. It may help reduce symptoms and lesion size, while also monitoring safety in children and adults.
Charleston, South CarolinaAges 2 years+ - NCT06789913RecruitingPhase 2
Testing RLY-2608 for growth disorders linked to PIK3CA mutations
This trial tests a new medicine, RLY-2608, that targets the specific genetic change (PIK3CA mutation) causing overgrowth conditions. It aims to see if the drug can slow or stop the growth of affected tissues.
Phoenix, ArizonaAges 2 years+ - NCT07378657RecruitingPhase 3
Sirolimus for children with orbital malformation
This trial tests if sirolimus can help children with a certain type of eye socket malformation. It aims to find a better treatment for children aged 1 to 18.
Cairo, Cairo GovernorateAges 1–18 - NCT06275022Recruiting
Using ICG dye to guide treatment of facial birthmarks
This study tests whether a special dye called ICG can help doctors treat a type of facial birthmark called capillary lymphatic malformation (cLM) more effectively. It may help by showing the birthmark more clearly during treatment.
Nanjing, JiangsuAges 4 weeks–16 years - NCT00833599Enrolling by invitation
Scan lymph drainage and collect samples for related conditions
This study uses a special light scan after a dye is given to look at how your lymph system drains. It may also include genetic testing for people with a family history of lymph-related disorders to better understand causes.
Houston, TexasAges 3 months+ - NCT03001180Recruiting
Study blood and tissue markers in vascular anomalies
This study collects extra blood (and sometimes tissue during procedures) to look for markers that can help doctors better understand vascular anomalies. It may not be a treatment, but it can improve future care by finding patterns linked to the condition.
Boston, MassachusettsAges 1 day+
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Lymphatic Malformation trials by city
Studies with a site in or near these metro areas.
Lymphatic Malformation trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for lymphatic malformation?
- Yes. Clin2 currently lists 15 recruiting lymphatic malformation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lymphatic malformation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lymphatic malformation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.