Tranexamic acid to reduce bleeding in spine surgery
Treatments studied
Part of Blood & lymphatic, Bones, joints & muscles clinical trials.
This Phase 3 trial tests whether tranexamic acid can reduce bleeding during major spine fusion surgery for adults with scoliosis or spine degeneration. It may help lessen blood loss and the need for transfusions, while monitoring safety.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between ages 18 and 80
- You are scheduled for a long spine fusion through the back (at least 5 spinal levels) for adult scoliosis or degenerative spine disease
- Your surgery plan includes a fusion that connects to the pelvis
- You are not having an anterior (front) surgical approach
- No major bleeding or clotting problems (kidney/liver issues, seizure history, major heart/stroke/clot history, or blood tests showing high bleeding risk)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether tranexamic acid (a medicine that helps blood clot) can reduce blood loss during long spine surgery after an injury. It may help lower the chance of needing transfusions and manage surgical bleeding.
This early-phase study tests if giving tranexamic acid (a medicine that helps blood clot) through a mist into the nose and sinuses during sinus surgery can reduce bleeding. It is designed for adults who are otherwise healthy and undergoing a common type of sinus surgery called functional endoscopic sinus surgery (FESS).
This trial studies whether giving tranexamic acid (a medicine that helps reduce bleeding) during planned lower-back decompression surgery can lower blood loss or related complications. It compares patients who receive the infusion during surgery to those who meet study procedures and safety requirements.
This trial studies whether a single dose or multiple doses of tranexamic acid (TXA) can reduce the chance you need a blood transfusion after spine fusion surgery. It also compares two different ways TXA may be given (by mouth and through a vein) to see which approach works best and is safe.
This trial tests whether putting a medicine called tranexamic acid (which helps reduce bleeding) on the surgery site can lessen the fluid that drains after a common type of lower-back spinal fusion surgery. It's for people having a single-level minimally invasive fusion, and it might help you recover with less drainage and fewer complications.
This study tests whether a medication called tranexamic acid can safely reduce blood loss during surgery to straighten the spine in teenagers with idiopathic scoliosis (a curved spine with no known cause). The goal is to help patients need fewer blood transfusions and recover better.
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