Testing tranexamic acid to reduce bleeding after spine fusion
Treatments studied
Part of Blood & lymphatic, Bones, joints & muscles clinical trials.
This trial studies whether a single dose or multiple doses of tranexamic acid (TXA) can reduce the chance you need a blood transfusion after spine fusion surgery. It also compares two different ways TXA may be given (by mouth and through a vein) to see which approach works best and is safe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You are scheduled for an open posterior thoracolumbar spine fusion operation
- You do NOT have an allergy to tranexamic acid (TXA)
- You must be willing to accept blood products if needed
- You have NOT taken blood thinners (anticoagulants) within 5 days before surgery
- You are not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether tranexamic acid (a medicine that helps blood clot) can reduce blood loss during long spine surgery after an injury. It may help lower the chance of needing transfusions and manage surgical bleeding.
This Phase 3 trial tests whether tranexamic acid can reduce bleeding during major spine fusion surgery for adults with scoliosis or spine degeneration. It may help lessen blood loss and the need for transfusions, while monitoring safety.
This trial studies whether giving tranexamic acid (a medicine that helps reduce bleeding) during planned lower-back decompression surgery can lower blood loss or related complications. It compares patients who receive the infusion during surgery to those who meet study procedures and safety requirements.
This trial tests if a medicine applied directly to the spine during a common type of back surgery (MI-TLIF) can reduce the amount of fluid that needs to be drained afterward. Tranexamic acid (TXA) helps blood clot, so using it this way may help you heal with less drainage.
This trial tests if taking tranexamic acid (TXA) pills for a week after knee replacement surgery helps reduce bleeding and the need for blood transfusions. You may qualify if you are having a planned first-time knee replacement with spinal anesthesia and are already scheduled for standard care.
This trial tests if a medicine called tranexamic acid can help reduce bleeding during surgery for lung cancer that has spread to the spine. It may be an option if you have a single tumor in your spine and are having separation surgery.
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