Low-dose blood thinner versus standard care after heart appendage closure
Treatments studied
Part of Heart & circulation clinical trials.
This study looks at whether a lower-dose blood thinner works as well as the usual recommended anti-clot treatment after a procedure that closes off the heart’s left atrial appendage. It may help reduce bleeding risk while still preventing dangerous blood clots.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have non-valvular atrial fibrillation and already had successful left atrial appendage occlusion (LAAO).
- Your doctor says you are able to take standard anti-clot treatment recommended for your condition.
- You are able to understand the study, sign consent, and follow study medication instructions.
- You are not pregnant or breastfeeding (and a pregnancy test may be required if you could become pregnant).
- You do not have major safety blockers like active/uncontrolled bleeding, serious medication allergies/contraindications, or certain recent strokes.
- You meet key timing and health limits (not unstable, no major recent procedures/PCI, no large leak around the device, and kidney function is not severely reduced).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares a heart device that can help prevent blood clots in the heart (called LAAO) versus long-term blood thinners for people who have atrial fibrillation and recently had a stent placed. It aims to see which approach better prevents stroke and related blood-clot problems while keeping side effects manageable.
This trial tests whether patients who receive a special device to close a hole in the heart (to prevent stroke from irregular heartbeat) can safely take fewer blood-thinning medications afterward. The study compares taking a standard blood thinner for 3 months versus taking aspirin only, to see which approach works best with fewer bleeding risks.
This trial compares a simpler procedure to the standard one for closing the left atrial appendage in people with non-valvular atrial fibrillation. The goal is to see which approach works better for preventing strokes while lowering bleeding risks.
This trial studies whether closing off part of the heart (the left atrial appendage) can prevent stroke as well as long-term newer blood-thinner pills. It may help people with atrial fibrillation who recently had a stroke or a warning stroke (TIA).
This trial tests whether a lower dose of the blood thinner rivaroxaban works as well as the standard dose for people 70 and older with atrial fibrillation (an irregular heartbeat). The goal is to find the safest dose to prevent strokes while reducing bleeding risks.
This trial tests whether it is safe for patients with atrial fibrillation to stop taking blood thinners after they have had heart surgery, including closure of the left atrial appendage. The goal is to see if these patients can avoid long-term medication without increasing the risk of stroke.
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