Metformin trial for vision nerve recovery in young people with MS
Treatments studied
Part of Brain & nervous system, Immune system & allergy clinical trials.
This study tests whether metformin can help “reset” damaged nerve cells in the brain and improve vision-related nerve problems in children and young adults with multiple sclerosis. Participants are assigned to metformin or a comparison treatment in a blinded (not everyone knows which) study.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Ages 10 to 25 years (and 11 months)
- MS history with vision-nerve involvement that has lasted more than 6 months since the last attack or event
- Eye testing must show signs of nerve damage: one or more abnormal eye measurements (VEP, OCT nerve layer thickness, or a big difference between eyes)
- If you take MS medicines, the dose and medicine must have stayed the same for the last 6 months
- Blood tests must show kidneys and liver are working well enough, with no major ongoing kidney/liver problems
- Not already taking metformin, and not recently treated with steroid doses for a relapse (within 30 days)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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