Sirolimus study for unruptured brain aneurysms after surgery
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This Phase 2 study tests whether sirolimus, a medicine that changes immune and growth signals, can change what’s happening inside the tissue of unruptured brain aneurysms after a procedure. Researchers hope these molecular changes may help understand how to improve aneurysm outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You are having treatment for an unruptured brain aneurysm at Jackson Memorial Hospital (clipping or endovascular treatment/coiling)
- You can understand the study and sign informed consent
- Your aneurysm is not a dissecting, traumatic, or infection-related (mycotic) type
- You are not allergic to sirolimus and do not have major uncontrolled health problems that would interfere with the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies whether sirolimus (Rapamune®) can reduce problems from severe arteriovenous malformations (tangled blood vessel connections). It may help shrink the abnormal vessels or improve symptoms, by testing the medicine in people with certain AVM types.
This trial tests if sirolimus, a medicine that may help reduce abnormal blood vessels, can prevent another brain bleed in people who recently had a bleed from a brainstem cavernoma. You would receive either sirolimus or a placebo to see if it works.
This Phase 3 study tests whether sirolimus helps control complex vascular anomalies that have not responded to standard treatments. It also checks safety by monitoring blood tests, organ function, and overall health during treatment.
This Phase 2 trial studies whether sirolimus can slow or prevent functional decline (more difficulty with daily activities) in older adults. You may be considered if you’re in the right age range and have no major heart, lung, liver, kidney, or recent bleeding/clotting problems.
This trial tests if the drug sirolimus can help people with focal seizures (starting in one part of the brain) that don't improve with at least two other medications. It aims to reduce seizure frequency in adults aged 18 to 60.
This trial studies whether taking sirolimus once a week can improve blood vessel, lymph vessel, or mixed (venolymphatic) malformations. It may help reduce symptoms and lesion size, while also monitoring safety in children and adults.
Hear when a new Cerebral Aneurysm trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.