Melatonin for diabetic eye disease and better sleep
Treatments studied
Part of Eyes & vision, Heart & circulation, Hormones & metabolism clinical trials.
This Phase 2 study tests whether melatonin can improve sleep and possibly outcomes related to diabetic retinopathy (damage to the retina from diabetes). It also checks whether it affects related symptoms while keeping people safe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have type 2 diabetes and are taking diabetes medicines (or have had A1C of 6.5% or higher)
- You are between 40 and 65 years old
- You have diabetic retinopathy that is at least moderate
- You are not already taking melatonin or other sedating sleep medicines
- You do not have certain eye problems (like significant scarring or swelling in specific parts of the eye) that would block study safety or measurements
- You do not have serious medical issues that are not well controlled (like severe heart failure, very high blood pressure, very poorly controlled diabetes, or severe untreated sleep apnea)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-phase study tests a treatment aimed at preventing or slowing early diabetic eye disease in people with mild, early changes. You may be considered if your diabetes is moderately controlled and your eye tests show early warning signs.
This trial tests whether melatonin can help relieve pain and discomfort from diabetic peripheral neuropathy (nerve damage caused by diabetes). If you have type 2 diabetes with nerve pain and are on stable diabetes medications, you may be eligible.
This trial tests whether taking melatonin (a natural sleep hormone) can help control blood sugar levels in pregnant women with gestational diabetes. It may offer a new, simple option to manage your condition and protect your health and your baby's.
This trial tests whether taking oral melatonin (a natural hormone) can help treat central serous chorioretinopathy, a condition where fluid builds up under the retina and blurs vision. It may be a good fit if you were recently diagnosed and haven't had certain eye procedures recently.
This trial tests whether giving melatonin at the right time can help people with bipolar disorder who are night owls improve their mood and sleep. You would take melatonin or a placebo each evening for a few weeks while tracking your symptoms on a phone app.
This trial tests a new inhaled form of melatonin to help adults aged 55 and older with insomnia fall asleep faster. It compares the inhaled melatonin to a placebo to see if it improves sleep and is safe.
Hear when a new Diabetes Mellitus trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.