Mesenchymal cells vs standard care for steroid-resistant graft-versus-host disease
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial studies a type of immune-support cell therapy (mesenchymal stromal cells) compared with the best available standard treatment for acute graft-versus-host disease (aGvHD) that does not respond to steroids. It may help by calming an overactive immune reaction after a stem cell transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You previously had an allogeneic stem cell transplant (for blood cancers or certain non-cancer blood/immune conditions)
- You currently have acute graft-versus-host disease that is Grade 2 to Grade 4
- Your aGvHD did not respond to first-line steroid treatment (it worsened quickly or did not improve, or only partially improved after a longer steroid-based treatment)
- Your expected survival is more than 28 days
- You are age 12 or older
- Your underlying disease is not clearly coming back or progressing at screening
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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