Aspirin and clopidogrel after left heart appendix closure
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial studies a “double anti-platelet” medicine plan (aspirin plus clopidogrel) after closing the left atrial appendage, a procedure used to reduce stroke risk in some heart rhythm conditions. It aims to find a safer, better medicine strategy for people who cannot take standard blood thinners.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and can give written consent for the study.
- You are being considered for left atrial appendage closure (LAAC) because your care team believes you need it.
- Your heart team agrees that you have a strong reason you cannot take oral anticoagulant (blood thinner) medicine.
- Your doctor says it is safe for you to take aspirin plus clopidogrel, and your bleeding risk is not considered too high.
- You do not have a known allergic reaction to aspirin and/or clopidogrel, and you do not have certain stomach bleeding or bleeding disorders.
- You can safely do an MRI scan (no certain implanted metal/devices, severe claustrophobia, or similar MRI limits).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether patients who receive a special device to close a hole in the heart (to prevent stroke from irregular heartbeat) can safely take fewer blood-thinning medications afterward. The study compares taking a standard blood thinner for 3 months versus taking aspirin only, to see which approach works best with fewer bleeding risks.
This trial compares which two medicines work best after a device closes off a part of the heart called the left atrial appendage. It may help reduce stroke risk while balancing bleeding risk after your procedure.
This trial looks at the best blood-thinning (antiplatelet) plan after a left atrial appendage closure procedure in people with kidney failure on dialysis. It may help reduce stroke risk while also lowering medicine-related side effects.
This study looks at whether a lower-dose blood thinner works as well as the usual recommended anti-clot treatment after a procedure that closes off the heart’s left atrial appendage. It may help reduce bleeding risk while still preventing dangerous blood clots.
This trial compares a simpler procedure to the standard one for closing the left atrial appendage in people with non-valvular atrial fibrillation. The goal is to see which approach works better for preventing strokes while lowering bleeding risks.
This study tests whether it is safe and effective to use just one blood thinner (aspirin or clopidogrel) for a short time after getting a LAmbre device implanted to close off a heart pouch that can cause strokes. It is for people with atrial fibrillation who cannot take standard blood thinners long-term.
Hear when a new Atrial fibrillation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.