Targeted drug plus focused brain radiation for breast cancer
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This study tests whether abemaciclib (a targeted pill) given with focused radiation to brain tumors can control hormone receptor–positive, HER2-negative breast cancer in the brain. It’s designed to see if the combination helps shrink or slow the growth of brain metastases while keeping side effects manageable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your breast cancer is hormone-receptor positive (ER and/or PR) based on a lab test from tumor tissue.
- Your breast cancer is HER2-negative (it does not show HER2 overexpression on tumor testing).
- You have 15 or fewer brain metastases that can be treated with focused radiation (SRS) and are measurable on scans.
- The biggest intact brain tumor is 4 cm or smaller, and you can swallow and take pills by mouth.
- You can manage the study schedule and have a good enough day-to-day function (performance status 0 to 2).
- You can provide saved tumor tissue (or slides) for extra lab testing, or enrollment may still be possible if tissue can’t be obtained.
- If you’ve been treated with radiation before, you must still have measurable disease and it must not have already been treated with radiation in those areas.
- You are not pregnant or breastfeeding, and if you could become pregnant you can do pregnancy testing and reliable contraception during treatment and for 3 weeks after the last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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