Clinical trials
Brain Metastases clinical trials
Below are recruiting brain metastases clinical trials, each written for real people, not researchers. We’re tracking 153 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05768490RecruitingPhase 3
Radiation plus targeted pills for EGFR lung cancer brain spots
This Phase 3 study tests whether giving brain radiation early or later, along with almonertinib (a targeted pill), works better for people with EGFR-mutated non-small cell lung cancer that has a small number of brain metastases. It aims to control brain disease while checking safety and effectiveness in a carefully selected group.
Guangdong, GuangzhouAges 18–75 - NCT05346367Recruiting
Targeted brain radiation to improve treatment benefit and limit side effects
This study tests a more targeted form of stereotactic (precise) brain radiation for people with brain metastases from large cell cancer. It aims to improve the balance between effectiveness and side effects by carefully focusing where the radiation goes.
Leidschendam, South HollandAges 18 years+ - NCT07511933Recruiting
New PET scan to detect tumor regrowth vs. scar tissue in brain
This study tests a new type of PET scan (a special imaging test) that uses a radioactive tracer to help doctors tell the difference between scar tissue from past radiation and cancer that has come back in the brain. This could help avoid unnecessary surgery or additional treatment.
AmsterdamAges Any age - NCT07505173RecruitingPhase 2
Targeted radiation plus osimertinib for brain metastases from EGFR-mutant lung cancer
This trial tests adding a brain-sparing radiation technique to the targeted therapy drug osimertinib for people with EGFR-mutant lung adenocarcinoma that has spread to the brain and is causing symptoms. The goal is to see if this combination can better control the brain tumors while protecting the hippocampus, a key memory area.
TianjinAges 18–75 - NCT07355348Recruiting
Cognitive support program for brain metastases
This study is testing a program to provide step-by-step cognitive support for adults whose cancer has spread to the brain. It aims to help people think more clearly and manage any memory or attention problems.
Toronto, OntarioAges 18 years+ - NCT07197632Recruiting
MRI during brain metastasis surgery
This study uses an MRI scan during surgery to help doctors remove brain metastases more completely. It may help ensure that all tumor tissue is removed.
MunichAges 18 years+ - NCT07130786RecruitingPhase 2
Preventing seizures with medication for brain tumors in movement area
This study tests whether giving a seizure medication (levetiracetam) to people with brain tumors in the movement area can prevent seizures. It compares taking the medication to not taking it, starting before any seizure occurs.
Boston, MassachusettsAges 18 years+ - NCT07132190RecruitingPhase 2
Radiation for growing brain tumors with same-day planning
This study tests whether a precise, one-day radiation treatment for brain tumors that are growing or in tricky spots can be effective with a smaller safety margin. It's designed for people whose brain tumors are changing quickly or sitting near areas of swelling or recent surgery.
Boston, MassachusettsAges 18 years+ - NCT07044557Recruiting
Avoiding dexamethasone in brain metastasis surgery
This trial tests whether skipping the steroid dexamethasone around brain tumor surgery is safe and effective for patients with brain metastases. If you have a new brain tumor and a mass elsewhere in your body, you may be able to join.
Louisville, KentuckyAges 18 years+ - NCT06992973Recruiting
Radiation before surgery for large brain metastases
This trial tests a new approach for people with a single large brain tumor that has spread from another cancer. You would receive a short, focused dose of radiation (stereotactic radiosurgery) in small, separate treatments, followed by surgery to remove the tumor. The goal is to see if this combination works better than the usual treatment.
RomeAges 18 years+ - NCT04847284Recruiting
Radiation during brain tumor surgery for brain metastases
This trial tests giving targeted radiation while surgeons are operating to treat brain metastases. It may help control the cancer locally at the time of surgery, especially for certain single lesions.
BarcelonaAges 18 years+ - NCT06974370RecruitingPhase 2
Avoiding brain radiation when chemo or other drugs work
This trial tests whether some people with brain metastases from solid tumors can safely skip radiation if their cancer drugs (like targeted therapy, immunotherapy, or certain chemotherapies) shrink the brain tumors. You will get MRI scans to see if the drugs are working.
Burlington, VermontAges 18 years+ - NCT06857006Recruiting
Comparing radiation margins for brain tumors
This trial tests two different radiation margins (how much healthy tissue is included around a brain tumor) during a single treatment session. It aims to see which margin is better at controlling brain metastases while reducing side effects.
Birmingham, AlabamaAges 19 years+ - NCT06727032Enrolling by invitation
Ai detection of brain metastases on MRI
This trial tests an artificial intelligence tool that automatically spots cancer spread to the brain on MRI scans. It may help doctors find brain metastases faster and more accurately for people with cancer outside the brain.
AmsterdamAges 18 years+ - NCT06471465RecruitingPhase 3
Avastin for brain swelling after radiation
This trial tests a drug called Avastin (bevacizumab) for people with brain swelling (radionecrosis) after radiation. It's for those whose symptoms don't get better with steroids or come back when steroids are reduced.
BrestAges 18 years+ - NCT06620380RecruitingPhase 2
Testing tumor samples to find the best drug for brain metastases
This trial tests tumor samples from brain metastases to see which drug might work best for you. It aims to guide your next treatment when standard options are limited.
BaselAges 18 years+ - NCT06280300Recruiting
Better care planning for people with brain metastases
This study looks at whether a team-based approach to care can improve quality of life for people newly diagnosed with brain metastases from solid tumors. It aims to help coordinate your medical and support needs.
Burlington, VermontAges 18 years+ - NCT06048094RecruitingPhase 1
PET scan study for brain metastases treated with radiosurgery
This trial tests a special PET scan (18F-fluciclovine) to see how well it shows brain metastases after stereotactic radiosurgery (a precise form of radiation). It may help doctors better understand treatment effects.
Miami, FloridaAges 18 years+ - NCT05559853Recruiting
MRI scan study to track brain tumor changes after treatment
This study tests a new MRI (brain scan) method to see how brain tumors change over time after treatment. There are also parts for healthy adults to help with developing and comparing the scan technique.
New York, New YorkAges 18 years+ - NCT05545007Recruiting
Pre-op vs post-op focused radiation for large brain metastases
This study compares giving focused, high-dose radiation before surgery versus after surgery for people with large brain metastases. The goal is to see which timing works best to control the tumors and help neurological outcomes.
Brescia, BresciaAges 18 years+ - NCT05419076RecruitingPhase 2
SRS radiation for small cell lung cancer with brain spread
This Phase 2 trial tests a type of focused radiation (stereotactic radiosurgery, or SRS) for people with small cell lung cancer that has spread to the brain. It looks at whether this approach can treat brain metastases when the cancer has limited to a certain number of spots.
Basking Ridge, New JerseyAges 18 years+ - NCT05378633Recruiting
CyberKnife treatment for multiple brain metastases
This trial looks at how well (and how much) CyberKnife radiation works for people with multiple brain metastases. It may help your care team understand the best way to treat several brain spots safely.
HeidelbergAges 18 years+ - NCT05124236Recruiting
Pre-surgery vs post-surgery focused radiation for brain metastases
This trial compares two ways of giving focused radiation for brain metastases: before surgery or after surgery. It aims to see which timing works better to control tumors while keeping you safe.
InnsbruckAges 18 years+ - NCT05013892RecruitingPhase 2
Whole-brain radiation with a targeted drug plan for brain mets
This Phase 2 study tests a treatment plan that combines whole-brain radiation therapy with an additional approach to help people with brain metastases. It aims to improve outcomes while also tracking brain function and memory over time.
Boston, MassachusettsAges 18 years+
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Brain Metastases trials by city
Studies with a site in or near these metro areas.
Brain Metastases trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for brain metastases?
- Yes. Clin2 currently lists 153 recruiting brain metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.