Clin2
NCT04974138Possibly a fitRecruiting

Preventing first stroke in people with high-risk blood pressure

HypertensionMTHFR 677 CC or CT GenotypeElevated Plasma Homocysteine (Hcy≥10µmol/L)Insufficient Plasma Folate Levels (<12ng/mL)

Part of Brain & nervous system, Heart & circulation clinical trials.

This trial tests whether a study medicine regimen can help prevent a first stroke in people with hard-to-control “high homocysteine” risk factors linked to a specific gene type. You may qualify if you have certain blood pressure levels, a specific MTHFR gene result, and related blood test findings.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
32,000 people
Ages
45 years to 74 years
Study type
Interventional

Who can take part

  • You’re between 45 and under 75 years old
  • You have primary (not secondary) high blood pressure—either on meds recently or high readings at two doctor visits
  • Your genetic test shows MTHFR 677 is CC or CT
  • Your blood tests show high homocysteine (at least 10) and low folate (below 12)
  • You’re able and willing to sign consent and follow the study plan
  • You have not had a stroke or major heart/blocked-artery event during the study’s early “run-in” period

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

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