Clinical trials
High blood pressure clinical trials
Persistently raised blood pressure, a major risk factor for heart disease and stroke. We’re tracking 990 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04808596Recruiting
Pulmonary hypertension registry and blood sample study
This study builds a registry and collection system for people with pulmonary hypertension, confirmed by a specific heart test. By joining, you help researchers learn more about the condition and may support future studies.
Kansas City, KansasAges 18 years+ - NCT07217522Recruiting
Genetics of pulmonary hypertension study
This study looks at the genes that may be linked to pulmonary hypertension. By providing a saliva sample and filling out a health survey from home, you can help researchers learn more about this condition.
Piscataway, New JerseyAges 18 years+ - NCT04071327Recruiting
Pulmonary hypertension registry for patient experiences
This trial is a registry that collects health information from people with pulmonary hypertension to better understand the disease and improve care. You may be asked to share details about your diagnosis and visits, especially soon after you start seeing a specialized PH care center.
Phoenix, ArizonaAges birth+ - NCT04555161Recruiting
Test of an implanted device for pulmonary arterial hypertension
This trial studies an implanted system (the Aria CV Pulmonary Hypertension System) to treat pulmonary arterial hypertension, a serious lung-blood vessel and heart condition. It aims to see whether the device can improve outcomes for people who are still sick despite existing PH medicines.
La Jolla, CaliforniaAges 18 years+ - NCT06281665RecruitingPhase 4
Aspirin after preeclampsia: the TAP trial
This trial tests whether taking low-dose aspirin after giving birth can help people who had preeclampsia. It aims to see if aspirin can lower the risk of future heart problems.
Pittsburgh, PennsylvaniaAges 18–55 - NCT06869031Recruiting
Helping rural patients manage high blood pressure with their doctor
This study tests a new way to help people with high blood pressure in rural areas manage their condition better. It focuses on improving how you and your doctor work together to keep your blood pressure under control.
Chengdu, SichuanAges 18–80 - NCT07120789Recruiting
Understanding pulmonary hypertension knowledge questionnaire
This study aims to validate a questionnaire that measures how well patients understand pulmonary hypertension. If you have been diagnosed with Group 1 Pulmonary Arterial Hypertension (PAH) and can read the questionnaire, you may be able to help researchers make sure it's a useful tool.
São Paulo, São PauloAges 18 years+ - NCT07511361RecruitingPhase 2
Tonlamarsen for high blood pressure after hospitalization
This study tests an investigational medication (Tonlamarsen) for people who were recently hospitalized for a very severe high blood pressure episode and also have heart or kidney disease. It aims to see if the drug can help control blood pressure after discharge.
Arvada, ColoradoAges 18 years+ - NCT03683186Enrolling by invitationPhase 3
Long-term study of ralinepag for pulmonary hypertension
This study follows people with pulmonary arterial hypertension (PAH) to see how safe and effective ralinepag is over the long term. It may help your care team understand what to expect from continued treatment and monitoring.
Phoenix, ArizonaAges 18 years+ - NCT07175038RecruitingPhase 2
Study of a new pill for pulmonary hypertension
This study tests a new pill, ROC-101, for people with pulmonary hypertension (high blood pressure in the lungs). It aims to see if the pill can improve symptoms and daily function.
Phoenix, ArizonaAges 18–80 - NCT07222852RecruitingPhase 3
Heart Protection After Preeclampsia With Enalapril
This trial tests whether the blood pressure medicine enalapril can help protect the hearts of people who had preeclampsia (a pregnancy-related high blood pressure condition) after they give birth. It is for those already in a hospital hypertension monitoring program.
Providence, Rhode IslandAges 18 years+ - NCT05462574Recruiting
MRI study of heart fat in pulmonary arterial hypertension
This trial uses MRI (and an additional MRI measurement called MRS) to study fat in the right side of the heart in people with pulmonary arterial hypertension (PAH). It may help researchers understand what’s going on in PAH and how it relates to symptoms and exercise ability.
Nashville, TennesseeAges 18 years+ - NCT05683093Recruiting
Follow-up study for adults after hypertensive pregnancy
This study follows young adults who previously joined the ALSPAC study to better understand long-term heart and metabolic health after a pregnancy affected by high blood pressure. You may be asked to return for visits and possibly an MRI, and your data may help researchers plan better long-term care.
Oxford, OxfordshireAges 30–40 - NCT06104228RecruitingPhase 2
Xenon MRI to detect and track pulmonary hypertension
This trial uses a special MRI scan (using xenon gas) to see how well the lungs are working in people with pulmonary arterial hypertension (PAH). It aims to improve diagnosis and monitoring of PAH from connective tissue disease or unknown cause.
Durham, North CarolinaAges 18–75 - NCT06554301RecruitingPhase 1
Empagliflozin for pulmonary arterial hypertension study
This study tests if the diabetes drug empagliflozin can help people with pulmonary arterial hypertension (PAH), a condition causing high blood pressure in the lungs. It aims to see if the drug improves symptoms and is safe for patients with moderate symptoms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06658522RecruitingPhase 4
Sotatercept for right heart function in pulmonary hypertension
This study tests a medicine called sotatercept to see if it can improve how the right side of your heart pumps in people with PAH. It may help you feel better and slow down the disease.
Amsterdam, North HollandAges 18–70 - NCT07013149Recruiting
Switching PAH medicines: does it change your risk?
This study looks at how changing from one PAH medicine (ambrisentan) to another (bosentan) affects your disease risk over time. It compares people who made the switch to those who stayed on ambrisentan.
São Paulo, São PauloAges 18 years+ - NCT06850792Recruiting
Improving treatment adherence with telemedicine and guidance
This study tests whether regular remote check-ins and guidance can help people with pulmonary arterial hypertension stick to their treatment plan. You would be followed by phone or video from University of Sao Paulo.
São Paulo, São PauloAges 18 years+ - NCT06899750Recruiting
E3 Hypertension: A team program for blood pressure control
This study tests a team-based program to help African American and Latinx people with uncontrolled high blood pressure. You'll use a smartphone app and get extra support from a doctor team to manage your blood pressure better.
Chicago, IllinoisAges 18 years+ - NCT06948838Recruiting
Improving blood pressure control in safety-net clinics
This study tests if a program to help primary care teams better manage high blood pressure can lower patients' blood pressure. It aims to find ways to improve care for people who get their care at community health centers or similar safety-net clinics.
Boston, MassachusettsAges 18 years+ - NCT06998329Recruiting
PAH diagnosis timing study
This study looks at the timing between first symptoms and diagnosis of pulmonary arterial hypertension (PAH). It aims to better understand how quickly patients get diagnosed after symptoms appear.
São Paulo, São PauloAges 18 years+ - NCT02061787Recruiting
Exercise testing to assess outcomes in pulmonary hypertension
This trial studies how well a treadmill/breathing exercise test can measure health outcomes in people with certain types of pulmonary hypertension. It may help your care team judge your status and track changes over time.
BeijingAges 5–100 - NCT03388476Enrolling by invitation
Breathing carbon dioxide measurement to detect lung high blood pressure
This trial tests whether measuring carbon dioxide you breathe out can help detect pulmonary hypertension earlier. It may help doctors spot this lung blood vessel condition sooner, especially around the time you get a heart test.
Giessen, HesseAges 18 years+ - NCT07604805Recruiting
Chinese herbal medicine for severe lung blood pressure
This trial tests whether Qishen Yiqi Dropping Pills, a traditional Chinese herbal medicine, can safely improve symptoms and heart function in people with severe pulmonary hypertension (abnormally high blood pressure in the lungs). You would take this medicine alongside or instead of other treatments to see if it helps you walk farther and feel better.
Guangzhou, GuagdongAges 18–75
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High blood pressure trials by city
Studies with a site in or near these metro areas.
High blood pressure trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for high blood pressure?
- Yes. Clin2 currently lists 990 recruiting high blood pressure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high blood pressure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.