Folic acid and intensive blood pressure treatment for stroke-related brain changes
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests whether combining folic acid supplements with intensive blood pressure treatment can help people who have had a small stroke or have certain brain changes seen on MRI. It may slow down further damage to the brain's small blood vessels.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 35 and 75 years old.
- You have had a small stroke (lacunar infarction) within the past year, or have specific white matter changes on an MRI, or have had a previous small stroke along with mild white matter changes.
- You have high blood pressure that is currently under some control (systolic between 130 and 180 mmHg depending on how many blood pressure medicines you take).
- You have not had a major stroke or disability (your daily activities are mostly independent).
- You have high homocysteine levels or a specific genetic variant (MTHFR 677 TT) linked to folic acid metabolism.
- You have not taken certain blood pressure or folic acid medications that cause side effects, and you do not have other serious conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how blood flow in the small vessels of the brain is affected after a stroke or in cerebral small vessel disease. It aims to better understand these conditions, which could help improve care in the future.
This study builds a brain imaging biobank for people with “small blood vessel disease” seen on MRI. Your MRI results can help researchers better understand these changes and track new events over time.
This trial tests how managing high blood pressure during clot-dissolving treatment for acute ischemic stroke affects recovery. It is for patients who have high blood pressure at the start of treatment.
This study tests whether using a specific blood pressure target after a stroke procedure can improve recovery. It may help patients who had a large vessel blockage in the brain and had successful treatment to reopen the vessel.
This trial tests whether a study medicine regimen can help prevent a first stroke in people with hard-to-control “high homocysteine” risk factors linked to a specific gene type. You may qualify if you have certain blood pressure levels, a specific MTHFR gene result, and related blood test findings.
This trial tests an approach to prevent first-time stroke and heart problems in people with high blood pressure who also have a specific genetic test result (MTHFR 677 TT). It may help by lowering risk before a first stroke happens.
Hear when a new Cerebral Small Vessel Diseases trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.