Cyclosporine then low-dose immune therapy for new type 1 diabetes
Treatments studied
Part of Hormones & metabolism, Immune system & allergy clinical trials.
This Phase 2 study tests whether starting with cyclosporine and then giving low-dose IL-2 can better protect the body’s insulin-producing function after type 1 diabetes is diagnosed. It’s meant for people diagnosed very recently who have specific diabetes-related immune markers.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 16 and 45 years old (must be fully developed—Tanner stage 5).
- You were diagnosed with type 1 diabetes within the last 3 months and have at least one diabetes autoantibody (like GAD, IA-2, or ZnT8).
- You cannot have diabetic ketoacidosis (“acid ketosis”) or have lost more than 10% of body weight (or you must meet a specific C-peptide level after starting insulin).
- Your blood, liver, kidney, thyroid tests, and other basic safety tests must be normal enough to join.
- You must not have certain heart problems (and you need a normal ECG), and you must not be pregnant or breastfeeding.
- You cannot have specific infections (like HIV, hepatitis B/C, or high EBV/CMV levels), cancer within the last 5 years, major immune/organ contraindications, or recent use of diabetes drugs other than insulin for over 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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