Medications during heart surgery to help control breathing and circulation
Treatments studied
Part of Heart & circulation clinical trials.
This study looks at whether giving dexamethasone and olanzapine during certain heart surgeries can improve how blood flow and ventilation (breathing support) are managed. It’s meant to see if these medicines help the body handle heart-lung bypass more safely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You have a planned CABG and/or AVR (coronary bypass and/or aortic valve replacement) on your surgery schedule.
- Your surgery must be done during normal scheduled hours (not “off hours”/urgent timing).
- You must not be pregnant or breastfeeding, and pregnancy will be tested before randomization if you can become pregnant.
- You can’t have certain active infections, like bacterial, viral, or fungal infection at screening.
- You must be able to take the study medicines and not have specific safety problems (for example, severe liver disease, severe low blood counts, long QT heart rhythm problem, or narrow-angle glaucoma).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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