Test pentoxifylline plus celecoxib for grand mal epilepsy on phenytoin
Treatments studied
Part of Brain & nervous system clinical trials.
This Phase 2 study tests whether adding two medicines—pentoxifylline and celecoxib—to current phenytoin treatment is safe and may help people with grand mal (generalized) epilepsy. It focuses mainly on safety while you stay on a single epilepsy medicine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have grand mal (generalized) epilepsy and take phenytoin alone (no other seizure medicines)
- If you can become pregnant: your pregnancy test is negative and you use reliable birth control
- Your liver and kidney tests are not significantly abnormal
- You do not have allergies to pentoxifylline or celecoxib (or known sulfonamide allergies)
- You should not have certain heart disease history, blood-bleeding events, or be on banned medicines
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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