Comparing blood thinners after aortic valve replacement
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial compares two blood-thinning treatments after aortic valve replacement with a tissue valve. It tests if a convenient pill (apixaban) is as safe and effective as aspirin alone, to prevent blood clots and other complications. Participation could help improve recovery and reduce the risk of strokes and bleeding.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have had a surgical replacement of your aortic valve using a tissue (bioprosthetic) valve, between 7 days and 1 month ago. This does not include TAVI procedures.
- You are not currently taking blood thinners for other reasons, such as atrial fibrillation or blood clots.
- You have not had any major bleeding in the past 3 months, and you are not at high risk of bleeding.
- Your kidney function is normal enough (creatinine clearance of 40 mL/min or higher), and you are not allergic to any of the study drugs (apixaban, aspirin, or heparin).
- You are not pregnant or planning to become pregnant, and you are not participating in another clinical trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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