Oral blood thinner after aortic valve bioprosthesis
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This Phase 3 study tests whether an oral blood thinner (apixaban) works for people who recently received a bioprosthetic aortic valve. It aims to prevent dangerous blood clots while checking safety, especially bleeding risk.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You had a surgical bioprosthetic (tissue) aortic valve placed at least 7 days ago and before leaving the hospital.
- You do NOT need long-term blood thinners for another reason like atrial fibrillation, pulmonary embolism, or similar conditions.
- You can sign informed consent and follow study rules.
- Your kidney function is good enough (creatinine clearance 40 mL/min or higher) so you would not need an apixaban dose reduction.
- You can take the study medicines safely: you are not at high risk for major bleeding, and you do not have conditions that make apixaban or aspirin unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study checks whether a blood-thinning medicine can treat problems with a bioprosthetic (man-made tissue) aortic valve. It focuses on valve “clots” that can happen after either a catheter-based or surgery-based valve replacement.
This study compares a blood thinner pill (a factor Xa inhibitor) with warfarin (vitamin K antagonist) in people who have had a mechanical aortic valve replacement. It looks at which option works better and is safer over the long term.
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This trial compares aspirin to warfarin in the first six months after receiving a bioprosthetic (tissue) heart valve. It aims to find which treatment better prevents blood clots without causing excessive bleeding.
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