Clinical trials
Aortic Valve Disease clinical trials
Below are recruiting aortic valve disease clinical trials, each written for real people, not researchers. We’re tracking 198 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07276711Recruiting
Protecting brain during TAVR with EmStop device
This trial tests a new device (EmStop) that helps protect your brain during TAVR (a type of heart valve replacement). The device is placed in arteries to catch any debris that might break loose during the procedure, potentially reducing the risk of stroke.
Thousand Oaks, CaliforniaAges 22 years+ - NCT05909748Recruiting
First-in-human test of a new TAVR valve for severe aortic narrowing
This trial tests a new heart valve replacement (TAVR) system in people with severe, symptomatic aortic stenosis. If you qualify, it may offer a less invasive option compared with open-heart valve surgery, while also helping researchers understand safety and early effectiveness.
Petah TikvaAges 18–120 - NCT07413965Recruiting
Transcatheter vs surgical valve replacement for severe bicuspid aortic stenosis
This trial compares two ways to replace a narrowed heart valve in people with a bicuspid aortic valve. If you're 50 or older and need a new valve, this study can help figure out which approach works best.
Los Angeles, CaliforniaAges 50 years+ - NCT07453407Recruiting
Tavi valve vs surgery for severe aortic regurgitation
This trial compares a new catheter-based valve (J-Valve) with open-heart surgery for people with severe aortic regurgitation, a condition where the aortic valve doesn't close tightly. It aims to see which treatment is safer and more effective.
Hefei, AnhuiAges 65 years+ - NCT05595226Recruiting
Ultrasound-guided mitral valve repair to improve heart outcomes
This study looks at whether using a special heart ultrasound during surgery (called RT3D-TEE) can lead to better results for people having mitral valve repair. It’s mainly for certain types of chronic mitral valve leakage.
Beijing, Beijing MunicipalityAges 18–80 - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+ - NCT07462624Recruiting
Comparing treatments for a failing surgical aortic valve
This trial compares two ways to treat a failing aortic valve that was replaced with a tissue valve during surgery: another surgical replacement or a less invasive catheter-based valve-in-valve procedure. It is for people with low to intermediate surgical risk who are between 18 and 75 years old.
Leipzig, SaxonyAges 18–75 - NCT07566624Recruiting
Registry study of Hydra heart valve replacement procedure
This study tracks patients who receive a Hydra artificial heart valve to replace a severely narrowed aortic valve. Researchers will follow your progress to understand how well the device works and its safety in real-world use.
Fuencarral-El PardoAges 18 years+ - NCT07008911Recruiting
Fitness program for heart rehabilitation
This trial tests if a popular fitness app can help people recover from heart problems. You would do workouts at home and see if they improve your health and recovery.
Aurora, ColoradoAges 18 years+ - NCT06953206Recruiting
Long-term study of a new heart valve for aortic stenosis
This study is testing a new heart valve called the SAPIEN 3 Ultra RESILIA valve for people with severe aortic stenosis. Researchers want to see how well it works and how safe it is over 10 years after a minimally invasive valve replacement procedure called TAVI.
Bad Oeynhausen, North Rhine-WestphaliaAges 18 years+ - NCT05283356RecruitingPhase 4
Ticagrelor or aspirin after heart valve replacement
This trial compares two blood thinners (ticagrelor and aspirin) to see which one works better at preventing blood clots after a less-invasive heart valve replacement (TAVI). It is for people with severe aortic stenosis who also have diabetes, heart disease, or artery disease.
Vigo, PontevedraAges 18 years+ - NCT05172973Recruiting
New valve procedure for failing aortic bioprosthetic valves
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
Newport Beach, CaliforniaAges Any age - NCT07709858Recruiting
Outcomes after TAVR for severe aortic valve disease
This is a registry study that tracks how people do after a TAVR procedure for a severely narrowed aortic heart valve. It helps doctors learn more about long-term outcomes and improve care for future patients.
SeoulAges 18 years+ - NCT07619872Recruiting
Safety study of KONECT RESILIA heart valve replacement
This study tracks how well a new artificial aortic valve and aorta graft (called KONECT RESILIA) work after surgery in real-world patients. Researchers want to understand if it's safe and performs well over time in people who need this valve replaced.
München, BavariaAges 18 years+ - NCT03003299Recruiting
Valve replacement for failing aortic bioprosthetic valves
This trial studies a new “valve-in-valve” procedure to treat a failing aortic bioprosthetic valve. It may help people improve blood flow through the heart valve and reduce valve-related problems.
Phoenix, ArizonaAges Any age - NCT03143361Recruiting
Aortic valve replacement registry for adults needing valve surgery
This study follows adults who are having aortic valve replacement to better understand outcomes across different hospitals in Europe. It may help your care team compare results and improve future treatment planning.
VeronaAges 18 years+ - NCT03470246Recruiting
Wearable activity coaching after heart surgery
This study tests a personalized activity program and coaching after heart surgery, using wearable sensors to track movement. It may help you recover more safely and move in a goal-directed way during rehabilitation.
KuopioAges 30–90 - NCT03600662Recruiting
Heart valve reconstruction using your own tissue
This trial studies a surgery to repair the aortic valve using tissue taken from your body. It may help people with significant valve problems, by testing whether this reconstruction approach works and is safe.
Munich, BavariaAges 50 years+ - NCT03826264Recruiting
Research registry for people getting TAVR
This is a research registry that collects information about people who receive TAVR, a procedure to help open a narrowed heart valve. It may help doctors understand outcomes and improve care, but it is not designed as a drug or device trial by itself.
Stanford, CaliforniaAges 19 years+ - NCT03972644Recruiting
Early valve replacement for people with severe but silent aortic narrowing
This trial tests whether replacing a badly narrowed aortic valve earlier—even when you feel fine—can prevent future heart problems. It compares early valve replacement (through a catheter or surgery) versus standard watchful waiting.
Odense, FynAges 18–85 - NCT04076150Recruiting
Testing a new valve placed through a blood vessel
This study checks whether an “investigational” transcatheter aortic valve is safe and works well for people with severe, calcified aortic stenosis (a stiff, narrowed heart valve). It may help improve valve function and symptoms, but you must meet specific heart, scan, and health-status requirements.
KrakowAges 70 years+ - NCT04126018Recruiting
MRI scan comparison for certain leaking or narrowed heart valves
This trial studies how well different MRI images can assess heart valve problems—like leaking (regurgitation) or narrowing (stenosis). It may help doctors get clearer information, especially in people who may not respond well to cardiac resynchronization therapy (CRT).
Cleveland, OhioAges 18–90 - NCT04258488RecruitingPhase 4
Blood thinner pill vs warfarin after mechanical aortic valve
This study compares a blood thinner pill (a factor Xa inhibitor) with warfarin (vitamin K antagonist) in people who have had a mechanical aortic valve replacement. It looks at which option works better and is safer over the long term.
Bucheon-siAges 19 years+ - NCT04414865Recruiting
Check a new heart valve treatment for older, high-risk patients
This study follows how the VitaFlow heart valve works in people age 70+ who have severe, narrowed aortic valves and cannot safely get open-heart valve surgery. It’s meant to see whether the device improves outcomes and is safe over time.
Shanghai, Shanghai MunicipalityAges 70 years+
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Aortic Valve Disease trials by city
Studies with a site in or near these metro areas.
Aortic Valve Disease trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for aortic valve disease?
- Yes. Clin2 currently lists 198 recruiting aortic valve disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic valve disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic valve disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.