Sedation-first vs usual care in ventilated trauma patients
Part of Brain & nervous system, Injuries & trauma, Lungs & breathing clinical trials.
This study compares how pain medicine and calming medicine are started in critically injured (trauma) adults who are on a breathing machine. It aims to see whether a specific “analgesia-first” approach can improve comfort and support breathing weaning.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You are on a breathing machine and doctors expect you’ll need it for at least 48 hours
- The ICU team has started a continuous pain/sedation medicine through an IV
- Your medical team thinks you may be able to come off the breathing machine soon
- You are not being treated with medicines that fully paralyze muscles (neuromuscular blocking agents)
- You do not have an allergy to midazolam, lorazepam, and/or propofol
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new way to manage sedation (medication to keep you calm and comfortable) for people on a breathing machine. The goal is to see if adjusting sedation based on your breathing effort leads to better outcomes and shorter time on the machine.
This study looks at how patients in the intensive care unit wake up from sedation and pain medication after being on a breathing machine. The goal is to understand how the medications affect recovery and to improve how they are stopped.
This trial compares two sedation medicines commonly used for patients on a breathing machine (ventilator). The goal is to see if one of them helps prevent confusion or delirium while patients are in the intensive care unit (ICU).
This study compares two types of sedation (medicine to keep you calm and comfortable) for people in the intensive care unit (ICU) who need a breathing machine. It looks at which approach is more cost-effective and may help guide better care.
This trial compares two different ways of giving sedatives and pain medicine to people who are on a breathing machine and have unstable blood pressure, to see which approach better keeps their heart and blood pressure stable. It will help doctors choose the safest sedation for critically ill patients.
This study looks at how different sedation practices affect outcomes in children who need a breathing machine. If your child is in the PICU and on a ventilator, this trial could help improve care.
Hear when a new Mechanical Ventilation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.