Lower-dose clot-busting medicine for infected chest fluid
Treatments studied
Part of Lungs & breathing clinical trials.
This study tests whether a lower dose of alteplase (a clot-busting medicine) given into the chest can improve healing of infected pleural fluid when drainage is incomplete. It may help reduce dosing-related side effects while still helping clear the infection-related fluid.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You currently have an infected pocket of fluid around the lung (pleural infection) and the chest drain has not fully drained it after at least 1 day
- You already have a chest drain in place (French size 12 or larger) and you’ve started antibiotics
- Your care team plans to use medicine through the drain that helps break up clots (intrapleural fibrinolytic)
- You are able and willing to sign informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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