Lower-dose clot-busting medicine for infected chest fluid
Treatments studied
Part of Lungs & breathing clinical trials.
This study tests whether a lower dose of alteplase (a clot-busting medicine) given into the chest can improve healing of infected pleural fluid when drainage is incomplete. It may help reduce dosing-related side effects while still helping clear the infection-related fluid.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You currently have an infected pocket of fluid around the lung (pleural infection) and the chest drain has not fully drained it after at least 1 day
- You already have a chest drain in place (French size 12 or larger) and you’ve started antibiotics
- Your care team plans to use medicine through the drain that helps break up clots (intrapleural fibrinolytic)
- You are able and willing to sign informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether injecting two medications (tPA and DNase) through a chest tube helps treat serious lung infections with fluid buildup. The goal is to see if this approach reduces the need for surgery and helps patients recover faster.
This trial tests whether a clot-busting medicine called alteplase, given through an existing chest tube (indwelling pleural catheter), can help drain fluid that has become trapped by fibrous bands. It may help relieve symptoms like shortness of breath.
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