Clin2
NCT05804084Possibly a fitRecruiting

Acetazolamide for sleep apnea: sleep and brain outcomes

Obstructive Sleep Apnea

Treatments studied

Part of Brain & nervous system, Lungs & breathing clinical trials.

This study tests acetazolamide (a medicine that changes breathing chemistry) to see how it affects sleep quality and neurocognitive (brain/memory/attention) outcomes in adults with untreated moderate to severe sleep apnea. You may be eligible if you have significant sleep apnea but do not have certain safety risks or need to start standard sleep apnea treatment right away.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
60 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older
  • Your body mass index (BMI) is 35 or less
  • Your sleep apnea is untreated and moderate to severe (AHI 15 or higher)
  • Your sleep test does not show very low oxygen levels during most of the night
  • You are not planning to start or restart standard sleep apnea treatment within the next 3 months
  • You can give consent and follow the study steps

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05953610Recruiting· Phase 2
Surgery study for sleep apnea when CPAP won’t work

This Phase 2 trial tests whether a specific type of palate surgery can treat moderate-to-severe obstructive sleep apnea in people who cannot tolerate CPAP (a breathing mask). It also checks patient traits (based on sleep testing) to see who is most likely to benefit from surgery.

Santa Monica, California
NCT05293600Recruiting· Phase 1/Phase 2
Rescue medicine trial for sleep apnea after other treatments fail

This trial studies a “rescue” set of medicines for obstructive sleep apnea when two common treatments haven’t worked well enough. If you still have frequent breathing pauses during sleep, the study may test whether these medicines can reduce them and improve safety and symptoms.

Boston, Massachusetts
NCT05988385Recruiting
Treating sleep apnea to protect memory in older adults

This study tests whether treating sleep apnea can help protect memory and brain health in older adults. It involves using a CPAP machine or other treatments for sleep apnea and may include memory tests and brain scans over 2 years.

Tucson, Arizona
NCT03858751Recruiting· Phase 1/Phase 2
Drug to activate a sleep-control pathway for sleep apnea

This early study tests a medicine that is meant to improve how your brain and breathing muscles work during sleep for obstructive sleep apnea (OSA). If you qualify, you would be monitored during sleep to see whether the treatment changes breathing events and oxygen levels.

Boston, Massachusetts
NCT06286189Recruiting· Phase 1/Phase 2
Testing trazodone for sleep apnea

This trial tests whether the medication trazodone can help people with moderate to severe obstructive sleep apnea (OSA). If you have OSA and are not taking certain medications or have other sleep disorders, you may be able to join.

Boston, Massachusetts
NCT06608888Recruiting
Brain chemical study for sleep apnea and snoring

This study looks at how a brain chemical called 5-HT7 affects sleep apnea by testing different groups: people with sleep apnea, people who snore, and healthy volunteers. It aims to find new ways to help regulate breathing during sleep.

Beijing, Beijing Municipality

Hear when a new Obstructive Sleep Apnea trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.