Venetoclax with isatuximab and dexamethasone for myeloma
Treatments studied
Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.
This trial tests a combination of three drugs (venetoclax, isatuximab, and dexamethasone) for people with multiple myeloma that has come back or stopped responding to earlier treatments. It is for patients whose cancer cells have a specific genetic change, called t(11;14).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have multiple myeloma that is active and has measurable levels of M-protein or free light chains in your blood or urine.
- Your cancer cells must have the t(11;14) genetic change, confirmed by a standard lab test (FISH).
- You must have been treated with at least one prior line of therapy, including a proteasome inhibitor, lenalidomide, and steroids.
- Your disease must have gotten worse (progressed) after your last treatment, based on standard criteria.
- You cannot have had treatment with venetoclax before, or with an anti-CD38 antibody like daratumumab or isatuximab in the last 3 weeks unless you had at least a minimal response.
- Your blood counts and organ function must be adequate (e.g., adequate white cells, platelets, and kidney function).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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