Better water pill therapy for acute heart failure
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests different water pill (diuretic) strategies for people hospitalized with acute heart failure and too much fluid. It is designed for patients who may not respond well to standard water pills, to find a more effective way to relieve symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old
- You are in the hospital with acute heart failure and have too much fluid in your body
- You have a higher risk of not responding to water pills (either because you took them daily for at least 7 days before admission or you didn't lose enough fluid/weight in the first 24 hours despite strong IV water pills)
- You have clear signs of fluid buildup, like swelling in your legs or belly, a bulging neck vein, or fluid in your lungs seen on a chest X-ray or ultrasound
- You do NOT have a recent heart attack, very low blood pressure, need for dialysis, or severely abnormal potassium/sodium levels
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares two treatments for sudden heart failure symptoms like severe shortness of breath. It aims to see whether opening blood vessels or using a water pill works better to relieve congestion and improve breathing.
This trial tests if dapagliflozin or acetazolamide works better for people hospitalized with heart failure who have extra fluid in their body (congestion). The study will compare how well each medication helps remove fluid when used with standard IV diuretics.
This trial studies how an IV (into-the-vein) “water pill” (furosemide/loop diuretic) works in people whose heart failure has suddenly gotten worse. It may help doctors find the best way to reduce fluid-related symptoms like breathing trouble and swelling.
This trial compares two different water pills (acetazolamide and metolazone) added to standard treatment to help remove excess fluid in people hospitalized with acute heart failure. The goal is to find which works better to ease symptoms and improve recovery.
This trial tests if adding a diuretic (water pill) called acetazolamide to usual care can help you get rid of extra fluid faster while you are in the hospital for worsening heart failure.
This trial tests whether adding an oral water pill (acetazolamide) to standard IV furosemide helps people with acute heart failure who have fluid overload. It aims to see if the combination improves outcomes better than furosemide alone.
Hear when a new Acute Heart Failure trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.