Eplerenone to prevent irregular heartbeat in people with heart disease
Treatments studied
Part of Heart & circulation clinical trials.
This study tests whether a medicine called eplerenone can help prevent atrial fibrillation from coming back in people who also have structural heart disease (changes in the heart's structure). If you have had episodes of irregular heartbeat that stopped, this drug might lower the chance of them returning.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have had brief episodes of atrial fibrillation (irregular heartbeat) that returned to normal rhythm with medication or an electrical procedure.
- You cannot have severe kidney problems (low kidney function or high creatinine).
- You cannot be taking certain heart medications like spironolactone or eplerenone already.
- You cannot have severe heart conditions like a prosthetic valve, severe mitral stenosis, or a weak heart pump (ejection fraction under 50%).
- You must not have thyroid problems, Wolff-Parkinson-White syndrome, severe liver disease, or a recent heart attack.
- You cannot be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether taking finerenone after a heart procedure to fix irregular heartbeat can help prevent atrial fibrillation from coming back. It's for people having their first such procedure and aims to improve long-term heart rhythm health.
This study tests whether finerenone, a medication that may help the heart work better, can improve electrical stability in people with a certain type of heart failure (HFpEF). It aims to reduce irregular heart rhythms and improve overall heart health.
This Phase 2 study tests whether eplerenone can improve outcomes after a heart attack (or similar heart injury) when coronary angiography shows no blocked heart arteries. It focuses on people with added cardiovascular risk factors and evaluates how well the treatment works for heart recovery and strain on the heart.
This trial tests if a common blood pressure and heart pill, spironolactone, can help keep your heart in a normal rhythm and prevent atrial fibrillation episodes from coming back. If you have high blood pressure and have had at least one AF episode in the last 6 months, you might be able to join.
This trial tests whether eplerenone (a blood pressure pill) can improve heart function in people who have had a kidney transplant and are taking cyclosporine or tacrolimus. It may help reduce the strain on the heart caused by these anti-rejection medicines.
This study tests a stepwise treatment plan for people with persistent atrial fibrillation (a long-lasting irregular heartbeat) who also have an enlarged left atrium. It aims to see if a medication called amiodarone plus a cardioversion procedure can help restore normal rhythm.
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