Early blood cell exchange for severe sickle chest syndrome
Part of Blood & lymphatic, Genetic & congenital, Lungs & breathing clinical trials.
This trial tests a fast, goal-based red blood cell exchange (a filter treatment) for people with sickle cell disease who develop severe acute chest syndrome and need extra oxygen. The goal is to see if starting it early helps recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older
- You have sickle cell disease (like SS, SC, Sbeta0, or Sbeta+)
- You have acute chest syndrome (fever, breathing trouble, and a new spot on your chest X-ray)
- You need at least 2 liters of oxygen per minute to keep your oxygen level normal
- Your doctor has recommended red blood cell exchange (a special blood filter treatment) for your low oxygen
- You have not already had a blood transfusion or this exchange for this same chest syndrome episode
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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